Publications by authors named "Samuel Outteridge"

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Mechanistic in vitro studies indicate that the clinical drug-drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3.
Robert Elsby, Hannah Coghlan, Jacob Edgerton, David Hodgson, Samuel Outteridge

Pharmacol Res Perspect· April 2023

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Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1.
Robert Elsby, Victoria Hare, Hannah Neal, Samuel Outteridge, Catherine Pearson

Drug Metab Dispos· January 2019

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Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Robert Elsby, Stephen Chidlaw, Samuel Outteridge, Sarah Pickering, Amy Radcliffe

Pharmacol Res Perspect· October 2017

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Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.
Mark R Thomas, Samuel N Outteridge, Ramzi A Ajjan, Fladia Phoenix, Gurpreet K Sangha

Arterioscler Thromb Vasc Biol· December 2015

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