Publications by authors named "Mark Layton"

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Acanthocytosis Contributes to the Diagnosis of the McLeod Syndrome.
D Mark Layton, Barbara J Bain

Am J Hematol· October 2025

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Long-term efficacy and safety of mitapivat in non-transfusion-dependent α- or β-thalassaemia: An open-label phase 2 study.
Kevin H M Kuo, D Mark Layton, Ashutosh Lal, Elliott P Vichinsky, Jayme L Dahlin

Br J Haematol· June 2025

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Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus.
Joshua D Vardigan, Parul S Pall, Dillon S McDevitt, ChienJung Huang, Michelle K Clements, Mark E Layton

Pain· March 2025

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Preclinical evaluation of MK-8189: A novel phosphodiesterase 10A inhibitor for the treatment of schizophrenia.
Sean M Smith, Dawn Toolan, Monika Kandebo, Joshua Vardigan, Izzat Raheem, Mark E Layton

J Pharmacol Exp Ther· January 2025

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Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.
Nadine Alvarez, Gregory C Adam, John A Howe, Vijeta Sharma, Matthew D Zimmerman, Mark E Layton

Viruses· July 2024

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Bone mineral density in adult patients with pyruvate kinase deficiency on long-term mitapivat treatment.
Hanny Al-Samkari, Rachael F Grace, Andreas Glenthøj, Oliver Andres, Wilma Barcellini, D Mark Layton

Haematologica· March 2024

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Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Valerie W Shurtleff, Mark E Layton, Craig A Parish, James J Perkins, John D Schreier

J Med Chem· March 2024

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Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis.
Wondimagegn Adissu, Marcelo Brito, Eduardo Garbin, Marcela Macedo, Wuelton Monteiro, Mark Layton

PLoS Negl Trop Dis· October 2023

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Putting unstable hemoglobins on the map of London.
Barbara J Bain, Amanda Hann, D Mark Layton

Am J Hematol· September 2023

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Hyperhaemolysis caused by anti-HI antibodies in a patient with myelodysplastic syndrome following a first ever red cell transfusion.
Richard Hinton, Ruby Haji, Richard Kaczmarski, Mark Layton, Akila Danga

Transfus Med· August 2023

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Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia.
Jonathan D Clayden, Hanne Stotesbury, Jamie M Kawadler, April Slee, Melanie Kӧlbel, Mark Layton

Blood Adv· June 2023

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Early-onset reduced bone mineral density in patients with pyruvate kinase deficiency.
Hanny Al-Samkari, Rachael F Grace, Andreas Glenthøj, Oliver Andres, Wilma Barcellini, D Mark Layton

Am J Hematol· March 2023

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The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design.
Rachael F Grace, Eduard J van Beers, Joan-Lluis Vives Corrons, Bertil Glader, Andreas Glenthøj, D Mark Layton

BMJ Open· March 2023

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A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).
Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Mark Layton

Eur Respir J· February 2023

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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
Mark E Layton, Jeffrey C Kern, Timothy J Hartingh, William D Shipe, Izzat Raheem

J Med Chem· January 2023

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Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve.
Rebecca M Klein, Mark E Layton, Hillary Regan, Christopher P Regan, Yuxing Li

Channels (Austin)· December 2022

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The use of next-generation sequencing in the diagnosis of rare inherited anaemias: A Joint BSH/EHA Good Practice Paper.
Noémi B A Roy, Lydie Da Costa, Roberta Russo, Paola Bianchi, Maria Del Mar Mañú-Pereira, Mark Layton

Br J Haematol· August 2022

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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study.
Kevin H M Kuo, D Mark Layton, Ashutosh Lal, Hanny Al-Samkari, Joy Bhatia

Lancet· August 2022

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Whole genome sequences discriminate hereditary hemorrhagic telangiectasia phenotypes by non-HHT deleterious DNA variation.
Katie E Joyce, Ebun Onabanjo, Sheila Brownlow, Fadumo Nur, Kike Olupona, D Mark Layton

Blood Adv· July 2022

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Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia.
Hanne Stotesbury, Patrick W Hales, Melanie Koelbel, Anna M Hood, Jamie M Kawadler, Mark Layton

J Cereb Blood Flow Metab· June 2022

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Voxelotor in sickle cell disease.
Barbara J Bain, Jane Myburgh, Amanda Hann, D Mark Layton

Am J Hematol· June 2022

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The Use of Next-generation Sequencing in the Diagnosis of Rare Inherited Anaemias: A Joint BSH/EHA Good Practice Paper.
Noémi B A Roy, Lydie Da Costa, Roberta Russo, Paola Bianchi, Maria Del Mar Mañú-Pereira, Mark Layton

Hemasphere· June 2022

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Quantification of Silent Cerebral Infarction on High-Resolution FLAIR and Cognition in Sickle Cell Anemia.
Hanne Stotesbury, Jamie M Kawadler, Jonathan D Clayden, Dawn E Saunders, Anna M Hood, Mark Layton

Front Neurol· June 2022

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Individual Watershed Areas in Sickle Cell Anemia: An Arterial Spin Labeling Study.
Hanne Stotesbury, Patrick W Hales, Anna M Hood, Melanie Koelbel, Jamie M Kawadler, Mark Layton

Front Physiol· May 2022

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Mitapivat versus Placebo for Pyruvate Kinase Deficiency.
Hanny Al-Samkari, Frédéric Galactéros, Andreas Glenthøj, Jennifer A Rothman, Oliver Andres, D Mark Layton

N Engl J Med· April 2022

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