Publications by authors named "Joshua D Vardigan"

Claim this Profile
A
Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus.
Joshua D Vardigan, Parul S Pall, Dillon S McDevitt, ChienJung Huang, Michelle K Clements

Pain· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Humanized Na1.8 rats overcome cross-species potency shifts in developing novel Na1.8 inhibitors.
Dillon S McDevitt, Joshua D Vardigan, Xiaoping Zhou, Thomas W Rosahl, Heather Zhou

Neurobiol Pain· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
2
2-Aminopyridines as Potent and Selective Na1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model.
Michael J Breslin, Jeffrey W Schubert, Deping Wang, Chienjung Huang, Michelle K Clements, Joshua D Vardigan

ACS Med Chem Lett· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
Michael T Rudd, Peter J Manley, Barbara Hanney, Zhaoyang Meng, Youheng Shu, Joshua D Vardigan

ACS Med Chem Lett· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Anthony J Roecker, Kathy M Schirripa, H Marie Loughran, Ling Tong, Tao Liang, Joshua D Vardigan

ACS Med Chem Lett· February 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey.
Henry S Lange, Joshua D Vardigan, Christopher E Cannon, Vanita Puri, Darrell A Henze

Neuropharmacology· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Na1.7 target modulation and efficacy can be measured in nonhuman primate assays.
Richard L Kraus, Fuqiang Zhao, Parul S Pall, Dan Zhou, Joshua D Vardigan

Sci Transl Med· May 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacological Characterization of the Novel and Selective 7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375.
Xiaohai Wang, Christopher Daley, Vanita Gakhar, Henry S Lange, Joshua D Vardigan

J Pharmacol Exp Ther· May 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects.
Joshua D Vardigan, Andrea K Houghton, Henry S Lange, Emily D Adarayan, Parul S Pall

J Pain Res· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity.
Joshua D Vardigan, Henry S Lange, Spencer J Tye, Steven V Fox, Sean M Smith

Psychopharmacology (Berl)· July 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model.
Vanita Puri, Xiaohai Wang, Joshua D Vardigan, Scott D Kuduk, Jason M Uslaner

Behav Brain Res· January 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey.
Joshua D Vardigan, Christopher E Cannon, Vanita Puri, Mandy Dancho, AmyJo Koser

Psychopharmacology (Berl)· June 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Sean M Smith, Jason M Uslaner, Christopher D Cox, Sarah L Huszar, Christopher E Cannon, Joshua D Vardigan

Neuropharmacology· January 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats.
Jason M Uslaner, Sean M Smith, Sarah L Huszar, Rashida Pachmerhiwala, Richard M Hinchliffe, Joshua D Vardigan

Neuropharmacology· March 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 attenuates a scopolamine-induced deficit in a novel rodent attention task.
Joshua D Vardigan, Antonella Converso, Pete H Hutson, Jason M Uslaner

J Neurogenet· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine.
Jason M Uslaner, Joshua D Vardigan, Jason M Drott, Victor N Uebele, John J Renger

Biol Psychiatry· October 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?
Joshua D Vardigan, Sarah L Huszar, Caitlyn H McNaughton, Peter H Hutson, Jason M Uslaner

Pharmacol Biochem Behav· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants.
Jason M Uslaner, Sean M Smith, Sarah L Huszar, Rashida Pachmerhiwala, Richard M Hinchliffe, Joshua D Vardigan

Psychopharmacology (Berl)· November 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis