Publications by authors named "Leander Grode"

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Challenge Dose Titration in a Infection Model in Goats.
Elisabeth M Liebler-Tenorio, Nadine Wedlich, Julia Figl, Heike Köhler, Reiner Ulrich, Leander Grode

Int J Mol Sci· September 2024

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Safety and immunogenicity of SIIPL Tdap, a new tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, in healthy subjects 4-65 years of age: A Phase II/III randomized, observer-blinded, active controlled, multicenter clinical study in Germany.
Inci Aydin, Marcus May, Fabio Pisano, Nontsikelelo Mpofu-Maetzig, Leander Grode

Vaccine· November 2023

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VPM1002 as Prophylaxis Against Severe Respiratory Tract Infections Including Coronavirus Disease 2019 in the Elderly: A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study.
Alexandra M Blossey, Sina Brückner, Marcus May, Gerald P Parzmair, Hitt Sharma, Leander Grode

Clin Infect Dis· April 2023

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Safety and Immunogenicity of Recombinant Strain VPM1002 and Its Derivatives in a Goat Model.
Julia Figl, Heike Köhler, Nadine Wedlich, Elisabeth M Liebler-Tenorio, Leander Grode

Int J Mol Sci· March 2023

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Safety and immunogenicity of VPM1002 versus BCG in South African newborn babies: a randomised, phase 2 non-inferiority double-blind controlled trial.
Mark F Cotton, Shabir A Madhi, Angelique K Luabeya, Michele Tameris, Anneke C Hesseling, Leander Grode

Lancet Infect Dis· October 2022

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Vaccine-Induced Subcutaneous Granulomas in Goats Reflect Differences in Host-Mycobacterium Interactions between BCG- and Recombinant BCG-Derivative Vaccines.
Elisabeth M Liebler-Tenorio, Johannes Heyl, Nadine Wedlich, Julia Figl, Heike Köhler, Leander Grode

Int J Mol Sci· September 2022

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Video Endoscopy-Guided Intrabronchial Spray Inoculation of in Goats and Comparative Assessment of Lung Lesions With Various Imaging Methods.
Nadine Wedlich, Julia Figl, Elisabeth M Liebler-Tenorio, Heike Köhler, Kerstin von Pückler, Leander Grode

Front Vet Sci· May 2022

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Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium Bacillus Calmette Guérin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy.
Cyrill A Rentsch, Piet Bosshard, Grégoire Mayor, Malte Rieken, Heike Püschel, Leander Grode

Oncoimmunology· July 2021

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Production Strategies for Pentamer-Positive Subviral Dense Bodies as a Safe Human Cytomegalovirus Vaccine.
Patricia Gogesch, Inessa Penner, Steffi Krauter, Nicole Büscher, Leander Grode

Vaccines (Basel)· September 2019

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The Recombinant Bacille Calmette-Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing.
Natalie E Nieuwenhuizen, Prasad S Kulkarni, Umesh Shaligram, Mark F Cotton, Cyrill A Rentsch, Leander Grode

Front Immunol· September 2017

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Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa.
André G Loxton, Julia K Knaul, Leander Grode, Andrea Gutschmidt, Christiane Meller

Clin Vaccine Immunol· February 2017

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The BCG replacement vaccine VPM1002: from drawing board to clinical trial.
Stefan He Kaufmann, Mark F Cotton, Bernd Eisele, Martin Gengenbacher, Leander Grode

Expert Rev Vaccines· May 2014

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Nonclinical Development of BCG Replacement Vaccine Candidates.
Kamalakannan Velmurugan, Leander Grode, Rosemary Chang, Megan Fitzpatrick, Dominick Laddy

Vaccines (Basel)· April 2013

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Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in a phase 1 open-label randomized clinical trial.
Leander Grode, Christian A Ganoza, Christiane Brohm, January Weiner, Bernd Eisele

Vaccine· February 2013

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Recombinant BCG ΔureC hly+ induces superior protection over parental BCG by stimulating a balanced combination of type 1 and type 17 cytokine responses.
Christiane Desel, Anca Dorhoi, Silke Bandermann, Leander Grode, Bernd Eisele

J Infect Dis· November 2011

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Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis.
Helmy Rachman, Michael Strong, Timo Ulrichs, Leander Grode, Johannes Schuchhardt

Infect Immun· February 2006

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Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin.
Leander Grode, Peter Seiler, Sven Baumann, Jürgen Hess, Volker Brinkmann

J Clin Invest· September 2005

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Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis.
Ann Williams, Graham J Hatch, Simon O Clark, Karen E Gooch, Kim A Hatch, Leander Grode

Tuberculosis (Edinb)· June 2005

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Comparative analysis of different vaccine constructs expressing defined antigens from Mycobacterium tuberculosis.
T Mark Doherty, Anja W Olsen, Joachim Weischenfeldt, Kris Huygen, Sushila D'Souza, Leander Grode

J Infect Dis· December 2004

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Application of mycobacterial proteomics to vaccine design: improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis.
Hans Joachim Mollenkopf, Leander Grode, Jens Mattow, Maik Stein, Peggy Mann

Infect Immun· November 2004

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Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles.
Hans-Joachim Mollenkopf, Guido Dietrich, Joachim Fensterle, Leander Grode, Klaus-Dieter Diehl

Vaccine· July 2004

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Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses.
Peter Aichele, Jana Zinke, Leander Grode, Reto A Schwendener, Stefan H E Kaufmann

J Immunol· August 2003

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Mycobacterial proteomes.
Hans-Joachim Mollenkopf, Jens Mattow, Ulrich E Schaible, Leander Grode, Stefan H E Kaufmann

Methods Enzymol· January 2003

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Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.
Heidrun Koebernick, Leander Grode, John R David, Wolfgang Rohde, Michael S Rolph

Proc Natl Acad Sci U S A· October 2002

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Cell-mediated immunity induced by recombinant Mycobacterium bovis Bacille Calmette-Guérin strains against an intracellular bacterial pathogen: importance of antigen secretion or membrane-targeted antigen display as lipoprotein for vaccine efficacy.
Leander Grode, Mischo Kursar, Joachim Fensterle, Stefan H E Kaufmann, Jürgen Hess

J Immunol· February 2002

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