Publications by authors named "Lee Gehrke"

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Oxidative Stress and Interferon Signaling Drive Differential Pathogenesis of Ancestral and Contemporary Zika Viruses in Human Cerebral Organoids.
Alfred T Harding, Yichen Zhang, Jane-Jane Chen, Jenna M Antonucci, Alexsia Richards, Lee Gehrke

bioRxiv· August 2025

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Human Brain Organoids: A New Model to Study Neurotropism.
Alfred T Harding, Lee Gehrke, Jatin M Vyas, Hannah Brown Harding

J Fungi (Basel)· July 2025

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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection.
Alexsia Richards, Andrew S Khalil, Max Friesen, Troy W Whitfield, Xinlei Gao, Lee Gehrke

Nat Commun· December 2024

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SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection.
Alexsia Richards, Andrew Khalil, Max Friesen, Troy W Whitfield, Xinlei Gao, Lee Gehrke

bioRxiv· November 2024

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Abortive infection of bat fibroblasts with SARS-CoV-2.
Punam Bisht, Michael D Gallagher, M Inmaculada Barrasa, Julie Boucau, Alfred Harding, Lee Gehrke

Proc Natl Acad Sci U S A· October 2024

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Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections.
Alfred T Harding, Karen Ocwieja, Minjin Jeong, Yichen Zhang, Valerie Leger, Lee Gehrke

mBio· April 2024

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Influence of previous Zika virus infection on acute dengue episode.
Cassia F Estofolete, Alice F Versiani, Fernanda S Dourado, Bruno H G A Milhim, Carolina C Pacca, Lee Gehrke

PLoS Negl Trop Dis· November 2023

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Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.
Robert Jordan, Stephanie L Ford-Scheimer, Rodolfo M Alarcon, Anthony Atala, Jeffrey T Borenstein, Lee Gehrke

J Infect Dis· October 2023

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Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika virus microcephaly.
Kimino Fujimura, Amanda J Guise, Tojo Nakayama, Christoph N Schlaffner, Anais Meziani, Lee Gehrke

iScience· July 2023

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Dengue and Zika virus differential infection of human megakaryoblast MEG-01 reveals unique cellular markers.
Paula X Losada, Irene Bosch, Galit H Frydman, Lee Gehrke, Carlos F Narváez

Virology· December 2022

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Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness.
Helena de Puig, Irene Bosch, Nol Salcedo, James J Collins, Kimberly Hamad-Schifferli, Lee Gehrke

Nano Today· December 2022

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SARS-CoV-2 infection of human pluripotent stem cell-derived liver organoids reveals potential mechanisms of liver pathology.
Alexsia Richards, Max Friesen, Andrew Khalil, M Inmaculada Barrasa, Lee Gehrke

iScience· October 2022

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FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation.
Caroline Junqueira, Ângela Crespo, Shahin Ranjbar, Luna B de Lacerda, Mercedes Lewandrowski, Lee Gehrke

Nature· June 2022

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Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion.
Setu M Vora, Pietro Fontana, Tianyang Mao, Valerie Leger, Ying Zhang, Lee Gehrke

Proc Natl Acad Sci U S A· March 2022

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Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction.
Minjin Jeong, Karen E Ocwieja, Dongjun Han, P Ashley Wackym, Yichen Zhang, Lee Gehrke

Commun Med (Lond)· October 2021

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SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.
Caroline Junqueira, Ângela Crespo, Shahin Ranjbar, Mercedes Lewandrowski, Jacob Ingber, Lee Gehrke

Res Sq· August 2021

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SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.
Caroline Junqueira, Ângela Crespo, Shahin Ranjbar, Jacob Ingber, Blair Parry, Lee Gehrke

medRxiv· March 2021

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Multiscale 3D phenotyping of human cerebral organoids.
Alexandre Albanese, Justin M Swaney, Dae Hee Yun, Nicholas B Evans, Jenna M Antonucci, Lee Gehrke

Sci Rep· December 2020

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Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy.
Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F Torti, Michael A Wheeler, Lee Gehrke

Nat Neurosci· October 2020

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Development and Validation of a Rapid Lateral Flow E1/E2-Antigen Test and ELISA in Patients Infected with Emerging Asian Strain of Chikungunya Virus in the Americas.
Ankita Reddy, Irene Bosch, Nol Salcedo, Bobby Brooke Herrera, Helena de Puig, Lee Gehrke

Viruses· September 2020

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AHR is a Zika virus host factor and a candidate target for antiviral therapy.
Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F Torti, Michael A Wheeler, Lee Gehrke

Nat Neurosci· August 2020

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Point-of-Care Devices to Detect Zika and Other Emerging Viruses.
Helena de Puig, Irene Bosch, James J Collins, Lee Gehrke

Annu Rev Biomed Eng· June 2020

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Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort.
Irene Bosch, Ankita Reddy, Helena de Puig, Juan E Ludert, Federico Perdomo-Celis, Lee Gehrke

PLoS Negl Trop Dis· June 2020

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A 3D human brain-like tissue model of herpes-induced Alzheimer's disease.
Dana M Cairns, Nicolas Rouleau, Rachael N Parker, Katherine G Walsh, Lee Gehrke

Sci Adv· May 2020

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Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation.
Anindita Basak, Mathias Munschauer, Caleb A Lareau, Kara E Montbleau, Jacob C Ulirsch, Lee Gehrke

Nat Genet· February 2020

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