Publications by authors named "Lee Helman"

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Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.
Srivandana Akshintala, R Taylor Sundby, Donna Bernstein, John W Glod, Rosandra N Kaplan, Lee J Helman

Clin Cancer Res· September 2023

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The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer.
Joseph A Flores-Toro, Subhashini Jagu, Gregory T Armstrong, David F Arons, Gregory J Aune, Lee J Helman

J Clin Oncol· August 2023

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A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma.
John A Ligon, R Taylor Sundby, Mary F Wedekind, Fernanda I Arnaldez, Jaydira Del Rivero, Lee J Helman

Clin Cancer Res· January 2023

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Recent Advances in Pediatric Cancer Research.
Troy A McEachron, Lee J Helman

Cancer Res· December 2021

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New Horizons in the Treatment of Osteosarcoma.
Paul S Meltzer, Lee J Helman

N Engl J Med· November 2021

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SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma.
Rashmi Chugh, Karla V Ballman, Lee J Helman, Shreyaskumar Patel, Jeremy S Whelan

Cancer· April 2021

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LRRC15 antibody-drug conjugates show promise as osteosarcoma therapeutics in preclinical studies.
Katherine K Slemmons, Sanjit Mukherjee, Paul Meltzer, James W Purcell, Lee J Helman

Pediatr Blood Cancer· February 2021

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Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Katherine K Slemmons, Choh Yeung, Joshua T Baumgart, Jhazeel O Martinez Juarez, Amy McCalla, Lee J Helman

Cancer Res· July 2020

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EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.
Sameer H Issaq, Arnulfo Mendoza, Ria Kidner, Tracy I Rosales, Damien Y Duveau, Lee J Helman

Mol Cancer Ther· July 2020

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Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas.
Emad Darvishi, Katherine Slemmons, Zesheng Wan, Sheetal Mitra, Xiaogang Hou, Lee J Helman

Neoplasia· July 2020

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CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.
Guillermo Flores, Joel H Everett, Elissa A Boguslawski, Brandon M Oswald, Zachary B Madaj, Lee J Helman

Mol Cancer Ther· May 2020

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Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung.
Kristin Baird, John Glod, Seth M Steinberg, Denise Reinke, Joseph G Pressey, Lee Helman

Sarcoma· April 2020

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A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor.
John Glod, Fernanda I Arnaldez, Lori Wiener, Melissa Spencer, J Keith Killian, Lee Helman

Clin Cancer Res· November 2019

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Insights into pediatric rhabdomyosarcoma research: Challenges and goals.
Marielle E Yohe, Christine M Heske, Elizabeth Stewart, Peter C Adamson, Nabil Ahmed, Lee J Helman

Pediatr Blood Cancer· October 2019

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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Choh Yeung, Anna E Gibson, Sameer H Issaq, Nobu Oshima, Joshua T Baumgart, Lee J Helman

Cancer Res· October 2019

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Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016).
Brigitte C Widemann, Yao Lu, Denise Reinke, Scott H Okuno, Christian F Meyer, Lee J Helman

Sarcoma· July 2019

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Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.
Sameer H Issaq, Arnulfo Mendoza, Stephen D Fox, Lee J Helman

Oncogenesis· February 2019

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Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
James J Morrow, Ian Bayles, Alister P W Funnell, Tyler E Miller, Alina Saiakhova, Lee J Helman

Nat Med· April 2018

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Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
James J Morrow, Ian Bayles, Alister P W Funnell, Tyler E Miller, Alina Saiakhova, Lee J Helman

Nat Med· February 2018

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Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma.
Christine M Heske, Mindy I Davis, Joshua T Baumgart, Kelli Wilson, Michael V Gormally, Lee J Helman

Clin Cancer Res· December 2017

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A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript.
Patrick J Grohar, John Glod, Cody J Peer, Tristan M Sissung, Fernanda I Arnaldez, Lee J Helman

Cancer Chemother Pharmacol· September 2017

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SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors.
Christine S Higham, Seth M Steinberg, Eva Dombi, Arie Perry, Lee J Helman

Sarcoma· September 2017

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Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma.
Jennifer M Kalish, Leslie Doros, Lee J Helman, Raoul C Hennekam, Roland P Kuiper

Clin Cancer Res· July 2017

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Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).
Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T Do, Baris Turkbey, Paul S Meltzer, Lee J Helman

J Clin Oncol· May 2017

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Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic.
Christopher B Weldon, Arin L Madenci, Sosipatros A Boikos, Katherine A Janeway, Suzanne George, Lee J Helman

J Clin Oncol· February 2017

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