Publications by authors named "Leon O Murphy"

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Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation.
Jacqueline Schmuckli-Maurer, Annina F Bindschedler, Rahel Wacker, Oliver M Würgler, Ruth Rehmann, Leon O Murphy

Commun Biol· November 2024

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Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency.
Jie Li, Francesca Moretti, Tunda Hidvegi, Sanja Sviben, James A J Fitzpatrick, Leon O Murphy

Cell Mol Gastroenterol Hepatol· May 2024

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Autophagy in the commercial arena: a conversation with Dr. Leon Murphy, Chief Scientific Officer at Casma therapeutics.
Leon O Murphy, Nicholas T Ktistakis

Autophagy· August 2023

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Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.
Simone Bonazzi, Audrey Gray, Noel M Thomsen, Jonathan Biag, Nancy Labbe-Giguere, Leon O Murphy

J Med Chem· July 2023

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A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages.
Melissa Bedard, Sanne van der Niet, Elliott M Bernard, Gregory Babunovic, Tan-Yun Cheng, Leon O Murphy

J Clin Invest· March 2023

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Jonathan M Goodwin, Ward G Walkup, Kirsty Hooper, Taoyingnan Li, Chieko Kishi-Itakura, Leon O Murphy

Sci Adv· October 2021

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Autophagy Assays for Biological Discovery and Therapeutic Development.
Noboru Mizushima, Leon O Murphy

Trends Biochem Sci· December 2020

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An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells.
Marek J Kobylarz, Jonathan M Goodwin, Zhao B Kang, John W Annand, Sarah Hevi, Leon O Murphy

PLoS One· September 2020

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Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.
Simone Bonazzi, Carleton P Goold, Audrey Gray, Noel M Thomsen, Jill Nunez, Leon O Murphy

J Med Chem· February 2020

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Targeting quiescent leukemic stem cells using second generation autophagy inhibitors.
Pablo Baquero, Amy Dawson, Arunima Mukhopadhyay, Elodie M Kuntz, Rebecca Mitchell, Leon O Murphy

Leukemia· April 2019

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TMEM41B is a novel regulator of autophagy and lipid mobilization.
Francesca Moretti, Phil Bergman, Stacie Dodgson, David Marcellin, Isabelle Claerr, Leon O Murphy

EMBO Rep· September 2018

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Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling.
Eva d'Hennezel, Sahar Abubucker, Leon O Murphy, Thomas W Cullen

mSystems· November 2017

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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Leon O Murphy

Nat Commun· November 2017

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Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.
Jonathan M Goodwin, William E Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Leon O Murphy

Cell Rep· September 2017

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Molecular definitions of autophagy and related processes.
Lorenzo Galluzzi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Leon O Murphy

EMBO J· July 2017

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Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
Marta Wlodarska, Chengwei Luo, Raivo Kolde, Eva d'Hennezel, John W Annand, Leon O Murphy

Cell Host Microbe· July 2017

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Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.
Ghayda M Mirzaa, Catarina D Campbell, Nadia Solovieff, Carleton Goold, Laura A Jansen, Leon O Murphy

JAMA Neurol· July 2016

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Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Leon O Murphy

Elife· June 2016

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Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.
Christina H Eng, Zuncai Wang, Diane Tkach, Lourdes Toral-Barza, Savuth Ugwonali, Leon O Murphy

Proc Natl Acad Sci U S A· January 2016

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Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.
Ayako Honda, Edmund Harrington, Ivan Cornella-Taracido, Pascal Furet, Mark S Knapp, Leon O Murphy

ACS Med Chem Lett· January 2016

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Small-molecule inhibitors: bULKing up mTOR inhibition.
Jonathan M Goodwin, Leon O Murphy

Nat Chem Biol· October 2015

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
William E Dowdle, Beat Nyfeler, Jane Nagel, Robert A Elling, Shanming Liu, Leon O Murphy

Nat Cell Biol· November 2014

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Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
Catia C Proenca, Natacha Stoehr, Mario Bernhard, Shanon Seger, Christel Genoud, Leon O Murphy

PLoS One· February 2014

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RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth.
Beat Nyfeler, Yan Chen, Xiaoyan Li, Maria Pinzon-Ortiz, Zuncai Wang, Leon O Murphy

PLoS One· May 2013

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Defective autophagy and mTORC1 signaling in myotubularin null mice.
Kristina M Fetalvero, Yenyen Yu, Margaret Goetschkes, Guiqing Liang, Reginald A Valdez, Leon O Murphy

Mol Cell Biol· January 2013

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