Publications by authors named "Wayne Pearce"

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Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN Hamartoma Tumour Syndrome.
Priyanka Tibarewal, Victoria Rathbone, Sarah E Conduit, Gala Anastasia Electra Classen, Fiona Black, Wayne Pearce

Dis Model Mech· November 2025

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Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality.
Sarah E Conduit, Cindy X W Zhang, Wayne Pearce, Julie Guillermet-Guibert, Amanda N Sferruzzi-Perri

Cell Mol Life Sci· November 2025

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Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock.
York Posor, Sarah E Conduit, Wayne Pearce, Daniele Morelli, Georgia Constantinou

Proc Natl Acad Sci U S A· July 2025

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A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease.
Sarah E Conduit, Wayne Pearce, Amandeep Bhamra, Benoit Bilanges, Laura Bozal-Basterra

Nat Commun· August 2024

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Factors influencing the successful implementation of a novel digital health application to streamline multidisciplinary communication across multiple organisations for emergency care.
Kathleen L Bagot, Chris F Bladin, Michelle Vu, Stephen Bernard, Karen Smith, Wayne Pearce

J Eval Clin Pract· March 2024

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Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development.
Priyanka Tibarewal, Victoria Rathbone, Georgia Constantinou, Wayne Pearce, Mahreen Adil

J Pathol· December 2022

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Real-world, feasibility study to investigate the use of a multidisciplinary app (Pulsara) to improve prehospital communication and timelines for acute stroke/STEMI care.
Chris F Bladin, Kathleen L Bagot, Michelle Vu, Joosup Kim, Stephen Bernard, Debra Pearce, Wayne Pearce

BMJ Open· July 2022

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Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.
Matt Lechner, Volker H Schartinger, Christopher D Steele, Wen Long Nei, Marc Lucas Ooft, Wayne Pearce

Nat Commun· January 2021

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Oncogenic promotes cellular stemness in an allele dose-dependent manner.
Ralitsa R Madsen, Rachel G Knox, Wayne Pearce, Saioa Lopez, Betania Mahler-Araujo

Proc Natl Acad Sci U S A· April 2019

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Comparing two laryngeal masks: the twin importance of a quantitative measure of the oropharyngeal sealing pressure, and the scrupulous avoidance of an excessive intracuff pressure.
Wayne Pearce, Sonia Vaida

Minerva Anestesiol· June 2018

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Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Inma M Berenjeno, Roberto Piñeiro, Sandra D Castillo, Wayne Pearce, Nicholas McGranahan

Nat Commun· November 2017

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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai

Nat Commun· November 2017

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Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Khaled Ali, Dalya R Soond, Roberto Piñeiro, Thorsten Hagemann, Wayne Pearce

Nature· July 2016

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Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.
Samira Alliouachene, Benoit Bilanges, Claire Chaussade, Wayne Pearce, Lazaros C Foukas

Diabetologia· July 2016

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Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.
Sandra D Castillo, Elena Tzouanacou, May Zaw-Thin, Inma M Berenjeno, Victoria E R Parker, Wayne Pearce

Sci Transl Med· March 2016

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Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.
Samira Alliouachene, Benoit Bilanges, Gaëtan Chicanne, Karen E Anderson, Wayne Pearce

Cell Rep· December 2015

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Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.
Julie Guillermet-Guibert, Lee B Smith, Guillaume Halet, Maria A Whitehead, Wayne Pearce

PLoS Genet· July 2015

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Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Khaled Ali, Dalya R Soond, Roberto Pineiro, Thorsten Hagemann, Wayne Pearce

Nature· June 2014

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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.
Adriana Soler, Helena Serra, Wayne Pearce, Ana Angulo, Julie Guillermet-Guibert

J Exp Med· September 2013

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Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.
Lazaros C Foukas, Benoit Bilanges, Lucia Bettedi, Wayne Pearce, Khaled Ali

EMBO Mol Med· April 2013

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Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth.
Vinothini Rajeeve, Wayne Pearce, Marta Cascante, Bart Vanhaesebroeck, Pedro R Cutillas

Biochem J· March 2013

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The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Ezra Aksoy, Salma Taboubi, David Torres, Sandrine Delbauve, Abderrahman Hachani, Wayne P Pearce

Nat Immunol· November 2012

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Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor.
Inma M Berenjeno, Julie Guillermet-Guibert, Wayne Pearce, Alexander Gray, Stewart Fleming

Biochem J· February 2012

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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
Mariona Graupera, Julie Guillermet-Guibert, Lazaros C Foukas, Li-Kun Phng, Robert J Cain, Wayne Pearce

Nature· May 2008

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Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.
Khaled Ali, Montserrat Camps, Wayne P Pearce, Hong Ji, Thomas Rückle

J Immunol· February 2008

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