Publications by authors named "Leon Pybus"

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Flux Sampling Suggests Metabolic Signatures of High Antibody-Producing CHO Cells.
Kate E Meeson, Joanne Watson, Susan Rosser, Ellie Hawke, Andrew Pitt, Leon Pybus

Biotechnol Bioeng· July 2025

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From Discovery to Delivery: A Rapid and Targeted Proteomics Workflow for Monitoring Chinese Hamster Ovary Biomanufacturing.
Charles Eldrid, Ellie Hawke, Kathleen M Cain, Kate Meeson, Joanne Watson, Leon Pybus

Mol Cell Proteomics· July 2025

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Deciphering molecular drivers of lactate metabolic shift in mammalian cell cultures.
Mauro Torres, Ellie Hawke, Robyn Hoare, Rachel Scholey, Leon P Pybus

Metab Eng· March 2025

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A modular and multi-functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing.
Leon P Pybus, Charles Heise, Tibor Nagy, Carmen Heeran, Terri Dover

Biotechnol Prog· August 2024

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Use of tRNA gene barriers improves stability of transgene expression in CHO cells.
Rebecca E Sizer, Richard M Ingram, Caroline Swan, Emma K Biggs, Leon P Pybus

Biotechnol J· August 2024

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Dissecting cell death pathways in fed-batch bioreactors.
David A Mentlak, John Raven, Tessa Moses, Fraser Massie, Nicholas Barber, Leon P Pybus

Biotechnol J· January 2024

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Coupling picodroplet microfluidics with plate imaging for the rapid creation of biomanufacturing suitable cell lines with high probability and improved multi-step assurance of monoclonality.
Leon P Pybus, Devika Kalsi, Joe T Matthews, Ellie Hawke, Nicholas Barber

Biotechnol J· January 2022

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Microbioreactor for lower cost and faster optimisation of protein production.
Mayur Parekh, AbdulAziz Ali, Zulfiqur Ali, Simon Bateson, Fathi Abugchem, Leon Pybus

Analyst· September 2020

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Scale-Down Model Development in ambr systems: An Industrial Perspective.
Viktor Sandner, Leon P Pybus, Graham McCreath, Jarka Glassey

Biotechnol J· April 2019

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Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain.
Leon P Pybus, David C James, Greg Dean, Tim Slidel, Colin Hardman

Biotechnol Prog· September 2014

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Model-directed engineering of "difficult-to-express" monoclonal antibody production by Chinese hamster ovary cells.
Leon P Pybus, Greg Dean, Nathan R West, Andrew Smith, Olalekan Daramola

Biotechnol Bioeng· February 2014

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Impact of gene vector design on the control of recombinant monoclonal antibody production by Chinese hamster ovary cells.
Sarah L Davies, Peter M O'Callaghan, Jane McLeod, Leon P Pybus, Yun Hee Sung

Biotechnol Prog· March 2012

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An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer.
Jane McLeod, Peter M O'Callaghan, Leon P Pybus, Stephen J Wilkinson, Tracy Root

Biotechnol Bioeng· September 2011

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HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.
Matt J Barter, Leon Pybus, Gary J Litherland, Andrew D Rowan, Ian M Clark

Matrix Biol· September 2010

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Cell line-specific control of recombinant monoclonal antibody production by CHO cells.
Peter M O'Callaghan, Jane McLeod, Leon P Pybus, Clare S Lovelady, Stephen J Wilkinson

Biotechnol Bioeng· August 2010

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