Publications by authors named "Leon Tertoolen"

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Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias.
Karina O Brandão, Lettine van den Brink, Duncan C Miller, Catarina Grandela, Berend J van Meer, Leon G J Tertoolen

Stem Cell Reports· November 2020

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Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.
Umber Saleem, Berend J van Meer, Puspita A Katili, Nurul A N Mohd Yusof, Ingra Mannhardt, Leon Tertoolen

Toxicol Sci· July 2020

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Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.
Elisa Giacomelli, Viviana Meraviglia, Giulia Campostrini, Amy Cochrane, Xu Cao, Leon G J Tertoolen

Cell Stem Cell· June 2020

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Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.
Xiaohang Qiao, Sabina Y van der Zanden, Dennis P A Wander, Daniel M Borràs, Ji-Ying Song, Leon G J Tertoolen

Proc Natl Acad Sci U S A· June 2020

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A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness.
Marcelo C Ribeiro, Rolf H Slaats, Verena Schwach, José M Rivera-Arbelaez, Leon G J Tertoolen

J Mol Cell Cardiol· April 2020

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Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes.
Berend J van Meer, Ana Krotenberg, Luca Sala, Richard P Davis, Thomas Eschenhagen, Leon G J Tertoolen

Nat Commun· September 2019

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Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-".
Vanesa Muncan, Owen J Sansom, Leon Tertoolen, Toby J Phesse, Harry Begthel

Mol Cell Biol· December 2018

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Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts.
Berend J van Meer, Luca Sala, Leon G J Tertoolen, Godfrey L Smith, Francis L Burton

Curr Protoc Hum Genet· October 2018

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MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.
Luca Sala, Berend J van Meer, Leon G J Tertoolen, Jeroen Bakkers, Milena Bellin

Circ Res· February 2018

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RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node.
Rebecca Vicente-Steijn, Tim P Kelder, Leon G Tertoolen, Lambertus J Wisse, Daniël A Pijnappels

Cardiovasc Res· August 2017

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Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).
Luca Sala, Dorien Ward-van Oostwaard, Leon G J Tertoolen, Christine L Mummery, Milena Bellin

J Vis Exp· May 2017

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Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells.
Elisa Giacomelli, Milena Bellin, Luca Sala, Berend J van Meer, Leon G J Tertoolen

Development· March 2017

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Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.
Berend J van Meer, Leon G J Tertoolen, Christine L Mummery

Stem Cells· August 2016

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Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure.
Georgios Kosmidis, Milena Bellin, Marcelo C Ribeiro, Berend van Meer, Dorien Ward-van Oostwaard, Leon G J Tertoolen

Biochem Biophys Res Commun· November 2015

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Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells.
Cathelijne W van den Berg, Satoshi Okawa, Susana M Chuva de Sousa Lopes, Liesbeth van Iperen, Robert Passier, Leon G Tertoolen

Development· September 2015

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Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology.
Marcelo C Ribeiro, Leon G Tertoolen, Juan A Guadix, Milena Bellin, Georgios Kosmidis

Biomaterials· May 2015

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Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
Cheryl Dambrot, Stefan R Braam, Leon G J Tertoolen, Matthew Birket, Douwe E Atsma

J Cell Mol Med· August 2014

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Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.
Milena Bellin, Simona Casini, Richard P Davis, Cristina D'Aniello, Jessica Haas, Leon G J Tertoolen

EMBO J· December 2013

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A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.
Carolien Wansleeben, Harma Feitsma, Leon Tertoolen, Carla Kroon, Victor Guryev

Int J Dev Biol· July 2011

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Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.
Stefan R Braam, Leon Tertoolen, Anja van de Stolpe, Thomas Meyer, Robert Passier

Stem Cell Res· March 2010

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Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction.
Linda W van Laake, Robert Passier, Jantine Monshouwer-Kloots, Arie J Verkleij, Daniel J Lips, Leon G Tertoolen

Stem Cell Res· October 2007

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Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells.
Monique E Quaedackers, Christina E van den Brink, Paul T van der Saag, Leon G J Tertoolen

Mol Cell Endocrinol· July 2007

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Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.
Vanesa Muncan, Owen J Sansom, Leon Tertoolen, Toby J Phesse, Harry Begthel

Mol Cell Biol· November 2006

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Patterning the heart, a template for human cardiomyocyte development.
Susana M Chuva de Sousa Lopes, Rutger J Hassink, Alie Feijen, Marga A van Rooijen, Pieter A Doevendans, Leon Tertoolen

Dev Dyn· July 2006

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Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1.
Stefania Mitola, Barbara Brenchio, Marco Piccinini, Leon Tertoolen, Luca Zammataro

Circ Res· January 2006

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