Publications by authors named "Leonard D Shultz"

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Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model.
Hannah R Megathlin, Lisa Burzenski, Michael A Brehm, Dale L Greiner, Sathy Balu-Iyer, Leonard D Shultz

J Pharm Sci· October 2025

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Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Katie C Coate, Chunhua Dai, Ajay Singh, Jade Stanley, Brittney A Covington, Leonard D Shultz

Mol Metab· December 2024

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Mapping histological and functional maturation of human endocrine pancreas across early postnatal periods.
Diane C Saunders, Nathaniel Hart, Fong Cheng Pan, Conrad V Reihsmann, Alexander L Hopkirk, Leonard D Shultz

bioRxiv· December 2024

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Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles.
Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Leonard D Shultz

Cells· October 2024

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Human insulin as both antigen and protector in type 1 diabetes.
Nitin P Amdare, Leonard D Shultz, Dale L Greiner, Teresa P DiLorenzo

Eur J Immunol· September 2024

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Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Katie C Coate, Chunhua Dai, Ajay Singh, Jade Stanley, Brittney A Covington, Leonard D Shultz

bioRxiv· August 2024

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Development of New Diffuse Large B Cell Lymphoma Mouse Models.
Syed Hassan Mehdi, Ying-Zhi Xu, Leonard D Shultz, Eunkyung Kim, Yong Gu Lee

Cancers (Basel)· August 2024

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Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice.
Zainul S Hasanali, Alfred L Garfall, Lisa Burzenski, Leonard D Shultz, Yan Tang

JCI Insight· May 2024

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Nuclear factor kappa B-dependent persistence of Typhi and Paratyphi in human macrophages.
Taylor A Stepien, Larissa A Singletary, Fermin E Guerra, Joyce E Karlinsey, Stephen J Libby, Leonard D Shultz

mBio· April 2024

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Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma.
Mason McCrury, Kennith Swafford, Sydnye L Shuttleworth, Syed Hassan Mehdi, Baku Acharya, Leonard D Shultz

Mol Cancer Ther· March 2024

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Human IL-6 fosters long-term engraftment of patient derived disease-driving myeloma cells in immunodeficient mice.
Zainul S Hasanali, Alfred L Garfall, Lisa Burzenski, Leonard D Shultz, Yan Tang

bioRxiv· January 2024

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Genetic risk converges on regulatory networks mediating early type 2 diabetes.
John T Walker, Diane C Saunders, Vivek Rai, Hung-Hsin Chen, Peter Orchard, Leonard D Shultz

Nature· December 2023

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Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model.
Bei Jia, Chenchen Zhao, Kentaro Minagawa, Hiroko Shike, David F Claxton, Leonard D Shultz

J Immunol· November 2023

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A human immune/muscle xenograft model of FSHD muscle pathology.
Katelyn Daman, Jing Yan, Lisa M Burzenski, Jamie Kady, Leonard D Shultz

bioRxiv· November 2023

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Generation of the NeoThy mouse model for human immune system studies.
Natalia M Del Rio, Liupei Huang, Lydia Murphy, Jayalaxmi Suresh Babu, Cross Matthew Daffada, Leonard D Shultz

Lab Anim (NY)· July 2023

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Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
Jiwon Yang, Jing Jiao, Kyle M Draheim, Guoxiang Yang, Hongyuan Yang, Leonard D Shultz

FASEB J· June 2023

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Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.
Joshua C Doloff, Minglin Ma, Atieh Sadraei, Hok Hei Tam, Shady Farah, Leonard D Shultz

Sci Adv· June 2023

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NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Ken-Edwin Aryee, Leonard D Shultz, Lisa M Burzenski, Dale L Greiner, Michael A Brehm

J Leukoc Biol· May 2023

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Humanized mouse models for immuno-oncology research.
Jane Chuprin, Hannah Buettner, Mina O Seedhom, Dale L Greiner, James G Keck, Leonard D Shultz

Nat Rev Clin Oncol· March 2023

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Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis.
Zheng Gong, Qing Li, Jiayuan Shi, Peishan Li, Li Hua, Leonard D Shultz

Sci Immunol· February 2023

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Clathrin light chain-conjugated drug delivery for cancer.
Sungwook Jung, Liwei Jiang, Jing Zhao, Leonard D Shultz, Dale L Greiner

Bioeng Transl Med· January 2023

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Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.
Zheng Gong, Qing Li, Jiayuan Shi, Edison T Liu, Leonard D Shultz

Cell Metab· December 2022

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Enhanced development of functional human NK cells in NOD-scid-IL2rg mice expressing human IL15.
Ken-Edwin Aryee, Lisa M Burzenski, Li-Chin Yao, James G Keck, Dale L Greiner, Leonard D Shultz

FASEB J· September 2022

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Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.
Zheng Gong, Qing Li, Jiayuan Shi, Jian Wei, Peishan Li, Leonard D Shultz

Immunity· August 2022

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Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.
Taylor A Stepien, Stephen J Libby, Joyce E Karlinsey, Michael A Brehm, Dale L Greiner, Leonard D Shultz

Methods Mol Biol· May 2022

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