Publications by authors named "Michael A Brehm"

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Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model.
Hannah R Megathlin, Lisa Burzenski, Michael A Brehm, Dale L Greiner, Sathy Balu-Iyer

J Pharm Sci· October 2025

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Partial remission of type 1 diabetes: Do immunometabolic events define the honeymoon period?
J Jason Collier, Clive H Wasserfall, Michael A Brehm, Michael D Karlstad

Diabetes Obes Metab· August 2025

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Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative.
Audrey V Parent, Ashutosh Agarwal, Juan Rene Alvarez-Dominguez, Rafael Arrojo E Drigo, Mark A Atkinson, Michael A Brehm

Diabetes· July 2025

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Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model.
Samuel Mon-Wei Yu, John Yongjoon Choi, Jamie Kady, Marina De Cos, Jenny S Wong, Michael A Brehm

Kidney Int· June 2025

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Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling.
Ayush Kumar, Hira Lal Goel, Christi A Silva, Tao Wang, Yansong Geng, Michael A Brehm

J Clin Invest· October 2024

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IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas.
Gulce Sari, Karthik Dhatchinamoorthy, Laura Orellano-Ariza, Lindsay M Ferreira, Michael A Brehm

Res Sq· September 2024

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Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor Growth.
Tatiana Novobrantseva, Denise Manfra, Jessica Ritter, Maja Razlog, Brian O'Nuallain, Michael A Brehm

Cancers (Basel)· August 2024

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The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.
Kevin W O'Connor, Kensei Kishimoto, Irena O Kuzma, Kelsey P Wagner, Jonathan S Selway, Michael A Brehm

Leukemia· May 2024

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Nuclear factor kappa B-dependent persistence of Typhi and Paratyphi in human macrophages.
Taylor A Stepien, Larissa A Singletary, Fermin E Guerra, Joyce E Karlinsey, Stephen J Libby, Michael A Brehm

mBio· April 2024

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CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
Naema Nayyar, Magali A de Sauvage, Jane Chuprin, Emily M Sullivan, Mohini Singh, Michael A Brehm

Clin Cancer Res· January 2024

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The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing.
Dimpi Mukhopadhyay, Hira Lal Goel, Choua Xiong, Shivam Goel, Ayush Kumar, Michael A Brehm

Cell Rep· November 2023

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A human immune/muscle xenograft model of FSHD muscle pathology.
Katelyn Daman, Jing Yan, Lisa M Burzenski, Jamie Kady, Leonard D Shultz, Michael A Brehm

bioRxiv· November 2023

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Generation and molecular characterization of human pluripotent stem cell-derived pharyngeal foregut endoderm.
Nicola A Kearns, Macrina Lobo, Ryan M J Genga, Ryan G Abramowitz, Krishna M Parsi, Michael A Brehm

Dev Cell· September 2023

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Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis.
Yetao Wang, Lawrence Lifshitz, Noah J Silverstein, Esther Mintzer, Kevin Luk, Michael A Brehm

EMBO J· August 2023

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γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors.
Cathal Harmon, Alexandra Zaborowski, Haim Moore, Pamela St Louis, Karen Slattery, Michael A Brehm

Nat Cancer· August 2023

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Generation of the NeoThy mouse model for human immune system studies.
Natalia M Del Rio, Liupei Huang, Lydia Murphy, Jayalaxmi Suresh Babu, Cross Matthew Daffada, Michael A Brehm

Lab Anim (NY)· July 2023

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Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
Jiwon Yang, Jing Jiao, Kyle M Draheim, Guoxiang Yang, Hongyuan Yang, Michael A Brehm

FASEB J· June 2023

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Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.
Joshua C Doloff, Minglin Ma, Atieh Sadraei, Hok Hei Tam, Shady Farah, Michael A Brehm

Sci Adv· June 2023

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NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Ken-Edwin Aryee, Leonard D Shultz, Lisa M Burzenski, Dale L Greiner, Michael A Brehm

J Leukoc Biol· May 2023

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Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies.
Priya Saikumar Lakshmi, Cliff I Oduor, Catherine S Forconi, Viriato M'Bana, Courtney Bly, Michael A Brehm

Life Sci Alliance· May 2023

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Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer.
Mengdie Wang, Christi A Silva, Choua Xiong, Peter Chhoy, Hira Lal Goel, Michael A Brehm

Sci Transl Med· May 2023

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I-A β56/57 polymorphisms regulate non-cognate negative selection to CD4 T cell orchestrators of type 1 diabetes.
Brian D Stadinski, Sarah B Cleveland, Michael A Brehm, Dale L Greiner, Priya G Huseby

Nat Immunol· April 2023

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Humanized mouse models for immuno-oncology research.
Jane Chuprin, Hannah Buettner, Mina O Seedhom, Dale L Greiner, James G Keck, Michael A Brehm

Nat Rev Clin Oncol· March 2023

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Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells.
Julia Schanin, Wouter Korver, Emily C Brock, John Leung, Zachary Benet, Michael A Brehm

Commun Biol· November 2022

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Enhanced development of functional human NK cells in NOD-scid-IL2rg mice expressing human IL15.
Ken-Edwin Aryee, Lisa M Burzenski, Li-Chin Yao, James G Keck, Dale L Greiner, Michael A Brehm

FASEB J· September 2022

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