Publications by authors named "Leonard Lothstein"

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A Spontaneous Assembling Lipopeptide Nanoconjugate Transporting the Anthracycline Drug -Benzyladriamycin-14-valerate for Personalized Therapy of Ewing Sarcoma.
Nirupama Sabnis, Sangram Raut, Bhavani Nagarajan, Ammar Kapic, Akpedje Serena Dossou, Leonard Lothstein

Bioconjug Chem· February 2024

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Pivarubicin Is More Effective Than Doxorubicin Against Triple-Negative Breast Cancer In Vivo.
Leonard Lothstein, Judith Soberman, Deanna Parke, Jatin Gandhi, Trevor Sweatman

Oncol Res· December 2020

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Formulation, Development, and In Vitro Evaluation of a CD22 Targeted Liposomal System Containing a Non-Cardiotoxic Anthracycline for B Cell Malignancies.
Nivesh K Mittal, Bivash Mandal, Pavan Balabathula, Saini Setua, Dileep R Janagam, Leonard Lothstein

Pharmaceutics· April 2018

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Involvement of PKC delta (PKCδ) in the resistance against different doxorubicin analogs.
María Ines Díaz Bessone, Damian E Berardi, Paola B Campodónico, Laura B Todaro, Leonard Lothstein

Breast Cancer Res Treat· April 2011

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Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline N-benzyladriamycin-14-valerate (AD 198).
Chun Cai, Leonard Lothstein, R Ray Morrison, Polly A Hofmann

J Pharmacol Exp Ther· October 2010

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Interferon-resistant Daudi cell line with a Stat2 defect is resistant to apoptosis induced by chemotherapeutic agents.
Ziyun Du, Meiyun Fan, Jong-Gwan Kim, Dara Eckerle, Leonard Lothstein

J Biol Chem· October 2009

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N-Benzyladriamycin-14-valerate (AD 198): a non-cardiotoxic anthracycline that is cardioprotective through PKC-epsilon activation.
Polly A Hofmann, Mervyn Israel, Yoshihiro Koseki, Jeffrey Laskin, Joshua Gray, Leonard Lothstein

J Pharmacol Exp Ther· November 2007

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N-Benzyladriamycin-14-valerate (AD 198) cytotoxicty circumvents Bcr-Abl anti-apoptotic signaling in human leukemia cells and also potentiates imatinib cytotoxicity.
Leonard Lothstein, Luydmila Savranskaya, Trevor W Sweatman

Leuk Res· August 2007

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Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid.
Yongwen He, Jihua Liu, Douglas Grossman, David Durrant, Trevor Sweatman, Leonard Lothstein

J Cell Biochem· August 2007

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N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx.
Leonard Lothstein, Luydmila Savranskaya, Christina M Barrett, Mervyn Israel, Trevor W Sweatman

Anticancer Drugs· June 2006

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N-benzyladriamycin-14-valerate (AD198) induces apoptosis through protein kinase C-delta-induced phosphorylation of phospholipid scramblase 3.
Yongwen He, Jihua Liu, David Durrant, Hung-Sheng Yang, Trevor Sweatman, Leonard Lothstein

Cancer Res· November 2005

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Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines.
Jennifer D Bilyeu, Ganesh R Panta, Lakita G Cavin, Christina M Barrett, Eddie J Turner, Leonard Lothstein

Mol Pharmacol· April 2004

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ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Ganesh R Panta, Swayamjot Kaur, Lakita G Cavin, Maria L Cortés, Frank Mercurio, Leonard Lothstein

Mol Cell Biol· March 2004

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Novel extranuclear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis.
Christina M Barrett, Felicia L Lewis, J Brent Roaten, Trevor W Sweatman, Mervyn Israel, Leonard Lothstein

Mol Cancer Ther· May 2002

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Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity.
J Brent Roaten, Marcelo G Kazanietz, Maria Jose Caloca, Paul J Bertics, Leonard Lothstein

Mol Cancer Ther· May 2002

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