Publications by authors named "David Durrant"

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An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state.
Daniel A Ritt, David E Durrant, Matthew R Drew, Suzanne I Sandin, Juliana A Martinez Fiesco

Proc Natl Acad Sci U S A· September 2025

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Free energy and flexibility analysis of autoinhibited human BRAF.
Jeremy O B Tempkin, Fikret Aydin, Sebnem Essiz, Yue Yang, Timothy S Carpenter, David E Durrant

bioRxiv· August 2025

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An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State.
Daniel A Ritt, David E Durrant, Matthew R Drew, Suzanne I Sandin, Juliana A Martinez Fiesco

bioRxiv· August 2025

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Tolypocladamides A-G: Cytotoxic Peptaibols from .
Sarath P D Senadeera, Dongdong Wang, Chang-Kwon Kim, Emily A Smith, David E Durrant

J Nat Prod· June 2022

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Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
Juliana A Martinez Fiesco, David E Durrant, Deborah K Morrison, Ping Zhang

Nat Commun· January 2022

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Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction.
David E Durrant, Emily A Smith, Ekaterina I Goncharova, Nirmala Sharma, Patrick A Alexander

Mol Cancer Ther· September 2021

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Therapeutic Effectiveness of AxioBionics Wearable Therapy Pain Management System in Patients with Chronic Lower Back Pain.
Philip Muccio, Josh Schueller, Miriam van Emde Boas, Norm Howe, Edward Dabrowski, David Durrant

Clin Med Insights Arthritis Musculoskelet Disord· February 2021

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STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in diabetic mice.
Arun Samidurai, Sean K Roh, Meeta Prakash, David Durrant, Fadi N Salloum

Cardiovasc Res· November 2020

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Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction.
Khoa Nguyen, Vinh Q Chau, Adolfo G Mauro, David Durrant, Stefano Toldo

J Cardiovasc Pharmacol Ther· September 2020

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A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines.
David E Durrant, Anindita Das, Samya Dyer, Rakesh C Kukreja

Biochim Biophys Acta Gen Subj· June 2020

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Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge That Inhibit Ras/Raf Interaction.
Chang-Kwon Kim, Dongdong Wang, Heidi R Bokesch, Richard W Fuller, Emily Smith, David E Durrant

J Nat Prod· April 2020

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.
Elizabeth M Terrell, David E Durrant, Daniel A Ritt, Nancy E Sealover, Erin Sheffels

Mol Cell· December 2019

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Targeting the Raf kinases in human cancer: the Raf dimer dilemma.
David E Durrant, Deborah K Morrison

Br J Cancer· January 2018

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Chronic treatment with novel nanoformulated micelles of rapamycin, Rapatar, protects diabetic heart against ischaemia/reperfusion injury.
Arun Samidurai, Fadi N Salloum, David Durrant, Olga B Chernova, Rakesh C Kukreja

Br J Pharmacol· December 2017

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Long-acting PDE5 inhibitor tadalafil prevents early doxorubicin-induced left ventricle diastolic dysfunction in juvenile mice: potential role of cytoskeletal proteins.
Mohamed Nagiub, Scott Filippone, David Durrant, Anindita Das, Rakesh C Kukreja

Can J Physiol Pharmacol· March 2017

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Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.
Daniel A Ritt, María T Abreu-Blanco, Lakshman Bindu, David E Durrant, Ming Zhou

Mol Cell· December 2016

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Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95.
Anindita Das, David Durrant, Clint Mitchell, Paul Dent, Surinder K Batra

Oncotarget· January 2016

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Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity.
David E Durrant, Anindita Das, Samya Dyer, Seyedmehrad Tavallai, Paul Dent

Mol Pharmacol· September 2015

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Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling.
Anindita Das, Fadi N Salloum, Scott M Filippone, David E Durrant, Gregg Rokosh

Basic Res Cardiol· May 2015

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PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer.
Anindita Das, David Durrant, Fadi N Salloum, Lei Xi, Rakesh C Kukreja

Pharmacol Ther· March 2015

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Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice.
Stefano Toldo, Anindita Das, Eleonora Mezzaroma, Vinh Q Chau, Carlo Marchetti, David Durrant

Circ Cardiovasc Genet· June 2014

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Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
Laurence Booth, Jane L Roberts, Nichola Cruickshanks, Adam Conley, David E Durrant

Mol Pharmacol· March 2014

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Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.
Anindita Das, David Durrant, Saisudha Koka, Fadi N Salloum, Lei Xi

J Biol Chem· February 2014

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Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice.
Amit Varma, Anindita Das, Nicholas N Hoke, David E Durrant, Fadi N Salloum

PLoS One· February 2013

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Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.
Anindita Das, Fadi N Salloum, David Durrant, Ramzi Ockaili, Rakesh C Kukreja

J Mol Cell Cardiol· December 2012

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