Publications by authors named "Leonard Presta"

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Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody-Drug Conjugate for Treatment of CLDN18.2-Positive Cancers.
Neil A O'Brien, Martina S J McDermott, Jun Zhang, Ke Wei Gong, Ming Lu, Leonard Presta

Mol Cancer Ther· December 2023

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An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Nina E Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O'Toole, Elizabeth Whalen, Leonard G Presta

Nat Commun· March 2023

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TCR mimic compounds for pHLA targeting with high potency modalities in oncology.
Hans-Peter Gerber, Leonard G Presta

Front Oncol· October 2022

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Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.
Judith T Murphy, Andre P Burey, Amy M Beebe, Danling Gu, Leonard G Presta

Blood· April 2014

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Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays.
Yanmei Lu, Jean-Michel Vernes, Nancy Chiang, Qinglin Ou, Jiabing Ding, Leonard G Presta

J Immunol Methods· February 2011

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Molecular engineering and design of therapeutic antibodies.
Leonard G Presta

Curr Opin Immunol· August 2008

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Evolving an anti-toxin antibody.
Leonard Presta

Nat Biotechnol· January 2007

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Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.
Stefka B Petkova, Shreeram Akilesh, Thomas J Sproule, Gregory J Christianson, Hana Al Khabbaz, Leonard G Presta

Int Immunol· December 2006

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Engineering of therapeutic antibodies to minimize immunogenicity and optimize function.
Leonard G Presta

Adv Drug Deliv Rev· August 2006

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Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab.
Camellia W Adams, David E Allison, Kelly Flagella, Leonard Presta, Janet Clarke

Cancer Immunol Immunother· June 2006

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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.
Yi Chen, Claire L Langrish, Brent McKenzie, Barbara Joyce-Shaikh, Jason S Stumhofer, Leonard Presta

J Clin Invest· May 2006

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Selection, design, and engineering of therapeutic antibodies.
Leonard G Presta

J Allergy Clin Immunol· October 2005

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Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody.
Yan Wang, Judith Hailey, Denise Williams, Yaolin Wang, Philip Lipari, Leonard Presta

Mol Cancer Ther· August 2005

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Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20.
Kyu Hong, Leonard G Presta, Yanmei Lu, Ashley Penn, Camellia Adams

J Immunol Methods· November 2004

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Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.
Charles Eigenbrot, Y Gloria Meng, Rajeswari Krishnamurthy, Michael T Lipari, Leonard Presta

J Mol Biol· August 2003

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Antibody engineering for therapeutics.
Leonard Presta

Curr Opin Struct Biol· August 2003

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Design, construction, and in vitro analyses of multivalent antibodies.
Kathy Miller, Gloria Meng, Jun Liu, Amy Hurst, Vanessa Hsei, Leonard Presta

J Immunol· May 2003

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Celebrating diversity and mimicking maturation.
Leonard G Presta

Nat Biotechnol· November 2002

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Engineering antibodies for therapy.
Leonard G Presta

Curr Pharm Biotechnol· September 2002

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity.
Robert L Shields, Jadine Lai, Rodney Keck, Lori Y O'Connell, Kyu Hong, Leonard G Presta

J Biol Chem· July 2002

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Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis.
Felix F Vajdos, Camellia W Adams, Timothy N Breece, Leonard G Presta, Abraham M de Vos

J Mol Biol· July 2002

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