Publications by authors named "Leonardo Leon"

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Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool.
J Henry Blackwell, Simon C C Lucas, Giovanni Battocchio, Ulf Börjesson, Mark J Bostock, Leonardo Leon

J Med Chem· December 2025

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Prognostic factors for recurrence in patients with papillary thyroid carcinoma.
José Antonio Hakim Tawil, María Fernanda Rojas, Juan José Santivañez, Leonardo León, Deyanira González Devia

Ear Nose Throat J· November 2025

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Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.
Adeline Palisse, Tony Cheung, Aileen Blokhuis, Thomas Cogswell, Bruna S Martins, Leonardo Leon

J Med Chem· December 2024

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors.
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt, Leonardo Leon

J Med Chem· September 2024

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Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.
Wenjing Liang, Shakti Sagar, Rishith Ravindran, Rita H Najor, Justin M Quiles, Leonardo J Leon

Nat Commun· August 2023

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The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction.
Wenjing Liang, Rachel Y Diao, Justin M Quiles, Rita H Najor, Liguo Chi, Leonardo J Leon

bioRxiv· February 2023

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COVID-19 spread, detection, and dynamics in Bogota, Colombia.
Rachid Laajaj, Camilo De Los Rios, Ignacio Sarmiento-Barbieri, Danilo Aristizabal, Eduardo Behrentz, Leonardo León

Nat Commun· August 2021

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Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.
Siting Zhu, Ze'e Chen, Mason Zhu, Ying Shen, Leonardo J Leon

Circ Heart Fail· June 2021

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Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise.
Alexandra G Moyzis, Navraj S Lally, Wenjing Liang, Leonardo J Leon, Rita H Najor

J Mol Cell Cardiol· September 2020

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Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia.
Sarah E Shires, Justin M Quiles, Rita H Najor, Leonardo J Leon, Melissa Q Cortez

Sci Rep· May 2020

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Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.
Babette C Hammerling, Sarah E Shires, Leonardo J Leon, Melissa Q Cortez, Åsa B Gustafsson

Small GTPases· January 2020

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BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.
Mark A Lampert, Amabel M Orogo, Rita H Najor, Babette C Hammerling, Leonardo J Leon

Autophagy· July 2019

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A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.
Babette C Hammerling, Rita H Najor, Melissa Q Cortez, Sarah E Shires, Leonardo J Leon

Nat Commun· January 2017

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Staying young at heart: autophagy and adaptation to cardiac aging.
Leonardo J Leon, Åsa B Gustafsson

J Mol Cell Cardiol· June 2016

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Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.
Chun-Yi Wu, Don-Hong Wang, Xiaobing Wang, Seth M Dixon, Liping Meng, Leonardo J Leon

ACS Comb Sci· June 2016

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Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells.
Ashley R Rowson-Hodel, Anastasia L Berg, Jessica H Wald, Jason Hatakeyama, Kacey VanderVorst, Leonardo J Leon

Cancer Lett· May 2016

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Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB.
Aaron T Wecksler, Sung Hee Hwang, Hiromi I Wettersten, Jennifer E Gilda, Amy Patton, Leonardo J Leon

Anticancer Drugs· April 2014

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A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells.
Leonardo J Leon, Nagarekha Pasupuleti, Fredric Gorin, Kermit L Carraway

PLoS One· November 2013

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5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor.
Nagarekha Pasupuleti, Leonardo Leon, Kermit L Carraway, Fredric Gorin

J Pharmacol Exp Ther· March 2013

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Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.
William Harley, Candace Floyd, Tamara Dunn, Xiao-Dong Zhang, Tsung-Yu Chen, Leonardo Leon

Brain Res· December 2010

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Spontaneous inflammatory cytokine gene expression in normal human peripheral blood mononuclear cells.
Moisés Armides Franco Molina, Edgar Mendoza Gamboa, Paloma Castillo Tello, Pablo Zapata Benavides, Leonardo Castillo León

Lymphat Res Biol· June 2007

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Apolipophorin III: lipopolysaccharide binding requires helix bundle opening.
Leonardo J Leon, Hasitha Idangodage, Chung-Ping L Wan, Paul M M Weers

Biochem Biophys Res Commun· October 2006

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Tyrosine fluorescence analysis of apolipophorin III-lipopolysaccharide interaction.
Leonardo J Leon, Cindy C Pratt, Lesley J Vasquez, Paul M M Weers

Arch Biochem Biophys· August 2006

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