Publications by authors named "Lesa Beamer"

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PGM1 deficiency disrupts sarcomere and mitochondrial function in a stem-cell cardiomyocyte model.
Silvia Radenkovic, Graeme Preston, Rohit Budhraja, Irena Muffels, Anna Ligezka, Lesa J Beamer

bioRxiv· July 2025

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Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8.
Vindya Samarakoon, Luckio F Owuocha, Jamie Hammond, Melissa G Mitchum, Lesa J Beamer

Biochem J· November 2024

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Structural insights into binding of polyglutamylated tetrahydrofolate by serine hydroxymethyltransferase 8 from soybean.
Luckio F Owuocha, Melissa G Mitchum, Lesa J Beamer

Front Plant Sci· August 2024

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Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance.
David A Korasick, Luckio F Owuocha, Pramod K Kandoth, John J Tanner, Melissa G Mitchum, Lesa J Beamer

FEBS J· January 2024

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Tracer metabolomics reveals the role of aldose reductase in glycosylation.
Silvia Radenkovic, Anna N Ligezka, Sneha S Mokashi, Karen Driesen, Lynn Dukes-Rimsky, Lesa J Beamer

Cell Rep Med· June 2023

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Effects of the T337M and G391V disease-related variants on human phosphoglucomutase 1: structural disruptions large and small.
Kyle M Stiers, Luckio F Owuocha, Lesa J Beamer

Acta Crystallogr F Struct Biol Commun· May 2022

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Enzyme dysfunction at atomic resolution: Disease-associated variants of human phosphoglucomutase-1.
Lesa J Beamer

Biochimie· April 2021

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Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction.
Sumi Lee, Dhulfiqar Ali Abed, Lesa J Beamer, Longqin Hu

SLAS Discov· January 2021

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A missense variant remote from the active site impairs stability of human phosphoglucomutase 1.
Kyle M Stiers, Reed P Hansen, Bana A Daghlas, Kelly N Mason, Jian-She Zhu, Lesa J Beamer

J Inherit Metab Dis· July 2020

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Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode.
David A Korasick, Pramod K Kandoth, John J Tanner, Melissa G Mitchum, Lesa J Beamer

J Biol Chem· March 2020

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Inhibitory Evaluation of αPMM/PGM from : Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study.
Jian-She Zhu, Kyle M Stiers, Ebrahim Soleimani, Brandon R Groves, Lesa J Beamer

J Org Chem· August 2019

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Assessment and Impacts of Phosphorylation on Protein Flexibility of the α-d-Phosphohexomutases.
Kyle M Stiers, Lesa J Beamer

Methods Enzymol· June 2019

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The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG.
Silvia Radenkovic, Matthew J Bird, Tim L Emmerzaal, Sunnie Y Wong, Catarina Felgueira, Lesa Beamer

Am J Hum Genet· May 2019

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Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated d-Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition.
Jian-She Zhu, Kyle M Stiers, Sherany M Winter, Anthony D Garcia, Antoine F Versini, Lesa J Beamer

ACS Omega· April 2019

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Structural and dynamical description of the enzymatic reaction of a phosphohexomutase.
Kyle M Stiers, Abigail C Graham, Jian-She Zhu, David L Jakeman, Jay C Nix, Lesa J Beamer

Struct Dyn· March 2019

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A Hotspot for Disease-Associated Variants of Human PGM1 Is Associated with Impaired Ligand Binding and Loop Dynamics.
Kyle M Stiers, Lesa J Beamer

Structure· October 2018

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Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily.
Kyle M Stiers, Andrew G Muenks, Lesa J Beamer

Adv Protein Chem Struct Biol· November 2017

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Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from .
Kyle M Stiers, Jia Xu, Yingying Lee, Zachary R Addison, Steven R Van Doren, Lesa J Beamer

ACS Omega· November 2017

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Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1.
Andrew G Muenks, Kyle M Stiers, Lesa J Beamer

PLoS One· October 2017

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Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts.
Jia Xu, Akella V S Sarma, Yirui Wei, Lesa J Beamer, Steven R Van Doren

Sci Rep· July 2017

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Structure and characterization of a class 3B proline utilization A: Ligand-induced dimerization and importance of the C-terminal domain for catalysis.
David A Korasick, Thameesha T Gamage, Shelbi Christgen, Kyle M Stiers, Lesa J Beamer

J Biol Chem· June 2017

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Asp263 missense variants perturb the active site of human phosphoglucomutase 1.
Kyle M Stiers, Abigail C Graham, Bailee N Kain, Lesa J Beamer

FEBS J· March 2017

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Data on the phosphorylation state of the catalytic serine of enzymes in the α-D-phosphohexomutase superfamily.
Yingying Lee, Cristina Furdui, Lesa J Beamer

Data Brief· February 2017

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Synchrotron-based macromolecular crystallography module for an undergraduate biochemistry laboratory course.
Kyle M Stiers, Christopher B Lee, Jay C Nix, John J Tanner, Lesa J Beamer

J Appl Crystallogr· December 2016

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Defining the Phenotype and Assessing Severity in Phosphoglucomutase-1 Deficiency.
Sunnie Yan-Wai Wong, Lesa J Beamer, Therese Gadomski, Tomas Honzik, Miski Mohamed

J Pediatr· August 2016

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