Publications by authors named "Leslie Mitchell"

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Human Genome REWRITE for Off-the-Shelf Stem Cells Reveals an "Epigenetic Ghost".
Serena F Generoso, Sarah Levovitz, Susanna Jaramillo, Minjoo Kim, Sumanth Dara, Leslie A Mitchell

bioRxiv· October 2025

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Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome.
Hugh D Goold, Heinrich Kroukamp, Paige E Erpf, Yu Zhao, Philip Kelso, Leslie A Mitchell

Nat Commun· January 2025

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The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.
Chun Zhou, Yun Wang, Yikun Huang, Yongpan An, Xian Fu, Leslie A Mitchell

Nat Commun· November 2024

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Serial monitoring of pancreatic lipase immunoreactivity, C-reactive protein, abdominal ultrasonography, and clinical severity in dogs with suspected pancreatitis.
Leslie Mitchell, Sichao Wang, Jody Lawver, Harry Cridge

J Vet Intern Med· March 2024

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Manipulating the 3D organization of the largest synthetic yeast chromosome.
Weimin Zhang, Luciana Lazar-Stefanita, Hitoyoshi Yamashita, Michael J Shen, Leslie A Mitchell

Mol Cell· December 2023

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Super-enhancers include classical enhancers and facilitators to fully activate gene expression.
Joseph W Blayney, Helena Francis, Alexandra Rampasekova, Brendan Camellato, Leslie Mitchell

Cell· December 2023

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Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions.
Yu Zhao, Camila Coelho, Amanda L Hughes, Luciana Lazar-Stefanita, Sandy Yang, Leslie A Mitchell

Cell· November 2023

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Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function.
Jingchuan Luo, Luis A Vale-Silva, Adhithi R Raghavan, Guillaume Mercy, Jonna Heldrich, Leslie A Mitchell

Cell Genom· November 2023

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Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast.
Yue Shen, Feng Gao, Yun Wang, Yuerong Wang, Ju Zheng, Leslie Mitchell

Cell Genom· November 2023

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Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration.
Jee Loon Foo, Shohei Kitano, Adelia Vicanatalita Susanto, Zhu Jin, Yicong Lin, Leslie A Mitchell

Cell Genom· November 2023

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Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics.
Benjamin A Blount, Xinyu Lu, Maureen R M Driessen, Dejana Jovicevic, Mateo I Sanchez, Leslie A Mitchell

Cell Genom· November 2023

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Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast strains.
Laura H McCulloch, Vijayan Sambasivam, Amanda L Hughes, Narayana Annaluru, Sivaprakash Ramalingam, Leslie A Mitchell

Cell Genom· November 2023

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Parallel laboratory evolution and rational debugging reveal genomic plasticity to synthetic chromosome XIV defects.
Thomas C Williams, Heinrich Kroukamp, Xin Xu, Elizabeth L I Wightman, Briardo Llorente, Leslie A Mitchell

Cell Genom· November 2023

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Racial and Gender Diversity Among Students and Faculty in EHAC-Accredited Environmental Health Sciences Programs: Trend Analysis from 2009 to 2021.
Jo Anne G Balanay, Leslie D Mitchell, Stephanie L Richards

Environ Health Insights· July 2022

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Transcriptional neighborhoods regulate transcript isoform lengths and expression levels.
Aaron N Brooks, Amanda L Hughes, Sandra Clauder-Münster, Leslie A Mitchell, Jef D Boeke

Science· March 2022

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De novo assembly and delivery to mouse cells of a 101 kb functional human gene.
Leslie A Mitchell, Laura H McCulloch, Sudarshan Pinglay, Henri Berger, Nazario Bosco

Genetics· May 2021

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A versatile platform for locus-scale genome rewriting and verification.
Ran Brosh, Jon M Laurent, Raquel Ordoñez, Emily Huang, Megan S Hogan, Leslie A Mitchell

Proc Natl Acad Sci U S A· March 2021

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Synthetic Genomes.
Weimin Zhang, Leslie A Mitchell, Joel S Bader, Jef D Boeke

Annu Rev Biochem· June 2020

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Technological challenges and milestones for writing genomes.
Nili Ostrov, Jacob Beal, Tom Ellis, D Benjamin Gordon, Bogumil J Karas, Leslie A Mitchell

Science· October 2019

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Author Correction: Precise control of SCRaMbLE in synthetic haploid and diploid yeast.
Bin Jia, Yi Wu, Bing-Zhi Li, Leslie A Mitchell, Hong Liu

Nat Commun· February 2019

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L-SCRaMbLE as a tool for light-controlled Cre-mediated recombination in yeast.
Lena Hochrein, Leslie A Mitchell, Karina Schulz, Katrin Messerschmidt, Bernd Mueller-Roeber

Nat Commun· May 2018

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Precise control of SCRaMbLE in synthetic haploid and diploid yeast.
Bin Jia, Yi Wu, Bing-Zhi Li, Leslie A Mitchell, Hong Liu

Nat Commun· May 2018

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Heterozygous diploid and interspecies SCRaMbLEing.
Michael J Shen, Yi Wu, Kun Yang, Yunxiang Li, Hui Xu, Leslie A Mitchell

Nat Commun· May 2018

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In vitro DNA SCRaMbLE.
Yi Wu, Rui-Ying Zhu, Leslie A Mitchell, Lu Ma, Rui Liu

Nat Commun· May 2018

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CK-2 of rainbow trout (Oncorhynchus mykiss) has two differentially regulated alleles that encode a functional chemokine.
Shawna L Semple, Shathi Eshaque, Kazuhiro Fujiki, Cynthia Tang, Leslie Mitchell

Vet Immunol Immunopathol· April 2018

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