Publications by authors named "Lian-Quan Gu"

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Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity.
Yong Rao, Yu-Ting Lu, Chan Li, Qin-Qin Song, Yao-Hao Xu, Lian-Quan Gu

Br J Pharmacol· August 2019

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Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.
Qian Yu, Hui Yang, Teng-Wei Zhu, Le-Mao Yu, Jian-Wen Chen, Lian-Quan Gu

Eur J Med Chem· May 2018

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Interaction of Quindoline derivative with telomeric repeat-containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2.
Yan Zhang, Deying Zeng, Jiaojiao Cao, Mingxue Wang, Bing Shu, Guotao Kuang, Lian-Quan Gu

Biochim Biophys Acta Gen Subj· December 2017

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Curcusone C induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2.
Mingxue Wang, Jiaojiao Cao, Jian-Yong Zhu, Jun Qiu, Yan Zhang, Lian-Quan Gu

Biochim Biophys Acta Proteins Proteom· November 2017

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Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis.
Yong Rao, Hong Yu, Lin Gao, Yu-Ting Lu, Zhao Xu, Lian-Quan Gu

Br J Pharmacol· August 2017

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Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.
Yu-Qing Wang, Zhou-Li Huang, Shuo-Bin Chen, Chen-Xi Wang, Chan Shan, Lian-Quan Gu

J Med Chem· August 2017

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Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.
De-Ying Zeng, Guo-Tao Kuang, Shi-Ke Wang, Wang Peng, Shu-Ling Lin, Lian-Quan Gu

J Med Chem· July 2017

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New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
Hui-Yun Liu, Ai-Chun Chen, Qi-Kun Yin, Zeng Li, Su-Mei Huang, Lian-Quan Gu

J Med Chem· July 2017

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Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.
Ming-Hao Hu, Shuo-Bin Chen, Bo Wang, Tian-Miao Ou, Lian-Quan Gu

Nucleic Acids Res· February 2017

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Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives.
Hui Yang, Hao-Wen Wang, Teng-Wei Zhu, Le-Mao Yu, Jian-Wen Chen, Lian-Quan Gu

Eur J Med Chem· February 2017

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Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex.
Chan Shan, Jin-Wu Yan, Yu-Qing Wang, Tong Che, Zhou-Li Huang, Lian-Quan Gu

J Med Chem· February 2017

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Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres.
Hui-Yun Liu, Qi Zhao, Tian-Peng Zhang, Yue Wu, Yun-Xia Xiong, Lian-Quan Gu

Cell Chem Biol· October 2016

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Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole.
Ming-Hao Hu, Shuo-Bin Chen, Yu-Qing Wang, You-Mei Zeng, Tian-Miao Ou, Lian-Quan Gu

Biosens Bioelectron· September 2016

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Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe.
Shuo-Bin Chen, Ming-Hao Hu, Guo-Cai Liu, Jin Wang, Tian-Miao Ou, Lian-Quan Gu

J Am Chem Soc· August 2016

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Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins.
Jun Qiu, Mingxue Wang, Yan Zhang, Ping Zeng, Tian-Miao Ou, Lian-Quan Gu

Curr Top Med Chem· March 2016

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Syntheses And Evaluation Of Asymmetric Curcumin Analogues As Potential Multifunctional Agents For The Treatment Of Alzheimer's Disease.
Peng Zhai, Chun-Li Xia, Jia-Heng Tan, Ding Li, Tian-Miao Ou, Lian-Quan Gu

Curr Alzheimer Res· February 2016

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Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.
Peng-Hui Li, Ping Zeng, Shuo-Bin Chen, Pei-Fen Yao, Yan-Wen Mai, Lian-Quan Gu

J Med Chem· January 2016

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Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.
Yong Rao, Hong Liu, Lin Gao, Hong Yu, Tian-Miao Ou, Lian-Quan Gu

J Med Chem· December 2015

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A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.
Yun-Xia Xiong, Hua-Fei Su, Peng Lv, Yan Ma, Shi-Ke Wang, Lian-Quan Gu

Oncotarget· November 2015

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A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology.
Ming-Hao Hu, Xiao Chen, Shuo-Bin Chen, Tian-Miao Ou, Meicun Yao, Lian-Quan Gu

Sci Rep· November 2015

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Role of Hairpin-Quadruplex DNA Secondary Structural Conversion in the Promoter of hnRNP K in Gene Transcriptional Regulation.
Jun Qiu, Jinggong Liu, Shuobin Chen, Tian-Miao Ou, Jia-Heng Tan, Lian-Quan Gu

Org Lett· September 2015

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Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.
Yong Rao, Hong Liu, Lin Gao, Hong Yu, Jia-Heng Tan, Lian-Quan Gu

Bioorg Med Chem· August 2015

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Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule.
Chan Shan, Jing Lin, Jin-Qiang Hou, Hui-Yun Liu, Shuo-Bin Chen, Lian-Quan Gu

Nucleic Acids Res· August 2015

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Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors.
Le-Mao Yu, Xiao-Ru Zhang, Xiao-Bing Li, Yuan Yang, Hong-Yu Wei, Lian-Quan Gu

Eur J Med Chem· August 2015

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Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression.
Ying-Chun Chen, Xiao-Yi Zeng, Yan He, Hong Liu, Bin Wang, Lian-Quan Gu

ACS Chem Biol· June 2015

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