Publications by authors named "Line Reinert"

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Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity.
Manja Idorn, Xiangning Ding, Stefanie Fruhwürth, Søren Holste, Line S Reinert

J Exp Med· January 2026

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Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein pre-formed fibrils Parkinson's disease mouse model.
Ida H Klæstrup, Line S Reinert, Sara A Ferreira, Johanne Lauritsen, Gitte U Toft

NPJ Parkinsons Dis· December 2025

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STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor.
Bao-Cun Zhang, Alice Pedersen, Line S Reinert, Ying Li, Ryo Narita

Nat Immunol· November 2025

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Sequelae of viral CNS infections including outcomes, mechanisms, and knowledge gaps.
Rachel Kelly, Line S Reinert, Søren R Paludan

Npj Viruses· November 2025

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Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2.
Lili Hu, Renee M van der Sluis, Kennith Brian Castelino, Bao-Cun Zhang, Andreas Ronit, Line S Reinert

Nat Commun· November 2025

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Neuropsychiatric- and cognitive post-acute sequelae of SARS-CoV-2 infection - evidence from K18-hACE C57BL/6 J mice.
Marco Maria Santi, Eleonora Genovese, Thor Mertz Schou, Matheus da Silva, Sophie Erhardt, Line Reinert

Int J Neuropsychopharmacol· October 2025

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STING Signaling Deficiency Exacerbates Demyelination and Immune Infiltration in Focal EAE Lesions.
Marlene T Mørch, Line S Reinert, Anouk Benmamar-Badel, Magdalena Dubik, Mark Burton

NeuroSci· October 2025

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Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Line Reinert

Adv Sci (Weinh)· October 2025

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Increased mucosal and T-cell expression of 4-1BB and PD-1 are modulated by anti-TNFα treatment in Crohn's disease.
Morten Aagaard Nielsen, Mia Bendix, Christian Lodberg Hvas, Bent Deleuran, Line S Reinert

Scand J Gastroenterol· July 2025

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Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection.
Xiangning Ding, Xin Lai, Ida H Klaestrup, Sara R N Jensen, Morten M Nielsen, Line S Reinert

J Neuroinflammation· May 2025

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Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion.
Ole A Ahlgreen, Mads W Hansen, Jonas Baake, Thomas E Hybel, Rachele Rossi, Line S Reinert

bioRxiv· May 2025

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Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice.
Anna Macht, Yiqi Huang, Line S Reinert, Vincent Grass, Kristin Lohmer

EMBO Rep· September 2024

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TMEFF1 is a neuron-specific restriction factor for herpes simplex virus.
Yao Dai, Manja Idorn, Manutea C Serrero, Xiaoyong Pan, Emil A Thomsen, Line S Reinert

Nature· August 2024

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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
Ensieh Farahani, Line S Reinert, Ryo Narita, Manutea C Serrero, Morten Kelder Skouboe

Cell Rep· February 2024

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STING activation counters glioblastoma by vascular alteration and immune surveillance.
Justin V Joseph, Mathilde S Blaavand, Huiqiang Cai, Fabienne Vernejoul, Rasmus W Knopper, Line Reinert

Cancer Lett· November 2023

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ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2.
Fanghui Ren, Ryo Narita, Ahmad S Rashidi, Stefanie Fruhwürth, Zongliang Gao, Line S Reinert

EMBO J· October 2023

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STING is redundant for host defense and pathology of COVID-19-like disease in mice.
Giorgia Marino, Baocun Zhang, Alexander Schmitz, Hanna Vf Schwensen, Line S Reinert

Life Sci Alliance· August 2023

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TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain.
Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson

Sci Adv· August 2023

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Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen.
Zaid Taha, Rozanne Arulanandam, Glib Maznyi, Elena Godbout, Madalina E Carter-Timofte, Line S Reinert

Mol Ther· September 2022

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TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection.
Renée M van der Sluis, Lamin B Cham, Albert Gris-Oliver, Kristine R Gammelgaard, Jesper G Pedersen, Line S Reinert

EMBO J· May 2022

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Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice.
Georgios Katzilieris-Petras, Xin Lai, Ahmad S Rashidi, Georges M G M Verjans, Line S Reinert

J Virol· March 2022

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B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation.
Kenneth Green, Thomas R Wittenborn, Cecilia Fahlquist-Hagert, Ewa Terczynska-Dyla, Nina van Campen, Line Reinert

Front Immunol· February 2022

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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses.
Isabelle K Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Line S Reinert

Cell Metab· January 2022

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A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Julián Valero, Laia Civit, Daniel M Dupont, Denis Selnihhin, Line S Reinert

Proc Natl Acad Sci U S A· December 2021

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The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice.
Rafael Bayarri-Olmos, Laust Bruun Johnsen, Manja Idorn, Line S Reinert, Anne Rosbjerg

Elife· November 2021

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