Publications by authors named "Linette Ruston"

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A Phase 1 Randomized, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Enteric-Coated Stabilized Sulforaphane (SFX-01) in Male Participants.
Glen Clack, Christopher Moore, Linette Ruston, David Wilson, Annelize Koch

Adv Ther· January 2025

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Discovery and Preclinical Evaluation of a Novel Inhibitor of FABP5, ART26.12, Effective in Oxaliplatin-Induced Peripheral Neuropathy.
George Warren, Myles Osborn, Christopher Tsantoulas, Ana David-Pereira, Daniel Cohn, Linette Ruston

J Pain· July 2024

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Determining bioequivalence possibilities of long acting injectables through population PK modelling.
Parmesh Gajjar, Jake Dickinson, Harri Dickinson, Linette Ruston, Hitesh B Mistry

Eur J Pharm Sci· December 2022

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IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.
Amais Ahmad, Xavier Pepin, Leon Aarons, Yuya Wang, Adam S Darwich, Linette Ruston

Eur J Pharm Biopharm· November 2020

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Discovery of (2)--[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.
Qibin Su, Erica Banks, Geraldine Bebernitz, Kirsten Bell, Cassandra F Borenstein, Linette Ruston

J Med Chem· May 2020

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
Neil P Grimster, Erica Anderson, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Linette Ruston

J Med Chem· June 2018

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Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.
Bernard Barlaam, Sabina Cosulich, Martina Fitzek, Hervé Germain, Stephen Green, Linette Ruston

Bioorg Med Chem Lett· July 2017

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.
Bernard Barlaam, Sabina Cosulich, Bénédicte Delouvrié, Rebecca Ellston, Martina Fitzek, Linette Ruston

Bioorg Med Chem Lett· November 2015

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Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.
Bernard Barlaam, Sabina Cosulich, Martina Fitzek, Stephen Green, Craig S Harris, Linette Ruston

Bioorg Med Chem Lett· July 2015

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Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
Kurt G Pike, Jeff Morris, Linette Ruston, Sarah L Pass, Ryan Greenwood

J Med Chem· March 2015

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Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Kurt G Pike, Karine Malagu, Marc G Hummersone, Keith A Menear, Heather M E Duggan, Linette Ruston

Bioorg Med Chem Lett· March 2013

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Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
Matt Addie, Peter Ballard, David Buttar, Claire Crafter, Gordon Currie, Linette Ruston

J Med Chem· March 2013

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Luminescence screening assays for the identification of sensitizers for lanthanides based on the controlled formation of ternary lanthanide complexes with DTPA-bisamide ligands.
Linette L Ruston, Graeme M Robertson, Zoe Pikramenou

Chem Asian J· March 2010

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Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.
Andrew G Leach, Huw D Jones, David A Cosgrove, Peter W Kenny, Linette Ruston

J Med Chem· November 2006

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