Publications by authors named "Lisa A Hasvold"

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Discovery of -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1-pyrrolo[2,3-]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
George S Sheppard, Le Wang, Steven D Fidanze, Lisa A Hasvold, Dachun Liu

J Med Chem· May 2020

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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Emily J Faivre, Keith F McDaniel, Daniel H Albert, Srinivasa R Mantena, Joshua P Plotnik, Lisa A Hasvold

Nature· February 2020

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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Steven D Fidanze, Dachun Liu, Robert A Mantei, Lisa A Hasvold, John K Pratt

Bioorg Med Chem Lett· June 2018

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Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
Keith F McDaniel, Le Wang, Todd Soltwedel, Steven D Fidanze, Lisa A Hasvold

J Med Chem· October 2017

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Methylpyrrole inhibitors of BET bromodomains.
Lisa A Hasvold, George S Sheppard, Le Wang, Steven D Fidanze, Dachun Liu

Bioorg Med Chem Lett· May 2017

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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
Le Wang, John K Pratt, Todd Soltwedel, George S Sheppard, Steven D Fidanze, Lisa A Hasvold

J Med Chem· May 2017

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Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells.
Andreas Höglund, Lisa M Nilsson, Somsundar Veppil Muralidharan, Lisa A Hasvold, Philip Merta

Clin Cancer Res· November 2011

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Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
Zhi-Fu Tao, Lisa A Hasvold, Joel D Leverson, Edward K Han, Ran Guan

J Med Chem· November 2009

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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.
Lisa A Hasvold, Le Wang, Magdalena Przytulinska, Zhan Xiao, Zehan Chen

Bioorg Med Chem Lett· April 2008

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Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
Le Wang, Gerard M Sullivan, Laura A Hexamer, Lisa A Hasvold, Reema Thalji

J Med Chem· August 2007

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Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Gaoquan Li, Lisa A Hasvold, Zhi-Fu Tao, Gary T Wang, Stephen L Gwaltney

Bioorg Med Chem Lett· April 2006

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Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Gary T Wang, Xilu Wang, Weibo Wang, Lisa A Hasvold, Gerry Sullivan

Bioorg Med Chem Lett· January 2005

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Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Lisa A Hasvold, Weibo Wang, Stephen L Gwaltney, Todd W Rockway, Lissa T J Nelson

Bioorg Med Chem Lett· November 2003

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Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides.
Richard C. Larock, Timothy R. Hightower, Lisa A. Hasvold, Karl P. Peterson

J Org Chem· May 1996

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