Publications by authors named "Lisa D Aimone"

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Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK).
Gregory R Ott, Mangeng Cheng, Keith S Learn, Jason Wagner, Diane E Gingrich, Lisa D Aimone

J Med Chem· August 2016

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3-(1'-Cyclobutylspiro[4H-1,3-benzodioxine-2,4'-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist.
Robert L Hudkins, John A Gruner, Rita Raddatz, Joanne R Mathiasen, Lisa D Aimone

Neuropharmacology· July 2016

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3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity.
Robert L Hudkins, Nadine C Becknell, Jacquelyn A Lyons, Lisa D Aimone, Mark Olsen

Eur J Med Chem· May 2015

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Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase.
Eugen F Mesaros, Thelma S Angeles, Mark S Albom, Jason C Wagner, Lisa D Aimone

Bioorg Med Chem Lett· March 2015

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Overview of pharmacokinetics.
Lisa D Aimone, Inés A M de Lannoy

Curr Protoc Pharmacol· September 2014

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Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.
Robert L Hudkins, Kurt A Josef, Nadine C Becknell, Lisa D Aimone, Jacquelyn A Lyons

Bioorg Med Chem Lett· March 2014

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Serendipitous discovery of a prodrug of a PARP-1 inhibitor.
Derek Dunn, Jean Husten, Lisa D Aimone, Mark A Ator, Sankar Chatterjee

Chem Biol Drug Des· September 2013

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Aryl-heteroaryl derivatives as novel wake-promoting agents.
Brigitte Lesur, Yin G Lin, Val R Marcy, Lisa D Aimone, John Gruner

Chem Biol Drug Des· March 2013

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Wake promoting agents: search for next generation modafinil, lessons learned: part III.
Derek Dunn, Greg Hostetler, Mohamed Iqbal, Val R Marcy, Yin Guo Lin, Lisa D Aimone

Bioorg Med Chem Lett· June 2012

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Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists.
Nadine C Becknell, Jacquelyn A Lyons, Lisa D Aimone, Zeqi Huang, John A Gruner

Bioorg Med Chem· June 2012

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A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779.
Benjamin J Dugan, Diane E Gingrich, Eugen F Mesaros, Karen L Milkiewicz, Matthew A Curry, Lisa D Aimone

J Med Chem· June 2012

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Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists.
Kurt A Josef, Lisa D Aimone, Jacquelyn Lyons, Rita Raddatz, Robert L Hudkins

Bioorg Med Chem Lett· June 2012

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Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase.
Diane E Gingrich, Joseph G Lisko, Matthew A Curry, Mangeng Cheng, Matthew Quail, Lisa D Aimone

J Med Chem· May 2012

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Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists.
Allison L Zulli, Lisa D Aimone, Joanne R Mathiasen, John A Gruner, Rita Raddatz

Bioorg Med Chem Lett· April 2012

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CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers.
Mangeng Cheng, Matthew R Quail, Diane E Gingrich, Gregory R Ott, Lihui Lu, Lisa D Aimone

Mol Cancer Ther· March 2012

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Synthesis and evaluation of a new series of 1'-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4'-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists.
Reddeppa Reddy Dandu, Jacquelyn A Lyons, Rita Raddatz, Zeqi Huang, Lisa D Aimone

Bioorg Med Chem Lett· March 2012

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Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.
Rabindranath Tripathy, Robert J McHugh, Edward R Bacon, Joseph M Salvino, George C Morton, Lisa D Aimone

Bioorg Med Chem Lett· February 2012

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4-phenoxypiperidine pyridazin-3-one histamine H(3) receptor inverse agonists demonstrating potent and robust wake promoting activity.
Robert L Hudkins, Allison L Zulli, Reddeppa reddy Dandu, Ming Tao, Kurt A Josef, Lisa D Aimone

Bioorg Med Chem Lett· February 2012

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Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.
Babu G Sundar, Thomas R Bailey, Derek Dunn, Greg A Hostetler, Sankar Chatterjee, Lisa D Aimone

Bioorg Med Chem Lett· February 2012

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4,5-dihydropyridazin-3-one derivatives as histamine H₃ receptor inverse agonists.
Robert L Hudkins, Lisa D Aimone, Reddeppa Reddy Dandu, Derek Dunn, John A Gruner

Bioorg Med Chem Lett· January 2012

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Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent.
Robert L Hudkins, Nadine C Becknell, Allison L Zulli, Ted L Underiner, Thelma S Angeles, Lisa D Aimone

J Med Chem· January 2012

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Synthesis and evaluation of 4-alkoxy-[1'-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4'-piperidine)] analogues as histamine-3 receptor antagonists.
Nadine C Becknell, Reddeppa Reddy Dandu, Jacquelyn A Lyons, Lisa D Aimone, Rita Raddatz

Bioorg Med Chem Lett· January 2012

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Novel brain penetrant benzofuropiperidine 5-HT₆ receptor antagonists.
Babu G Sundar, Thomas R Bailey, Derek D Dunn, Edward R Bacon, Joseph M Salvino, Lisa D Aimone

Bioorg Med Chem Lett· January 2012

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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.
Craig A Zificsak, Diane E Gingrich, Henry J Breslin, Derek D Dunn, Karen L Milkiewicz, Lisa D Aimone

Bioorg Med Chem Lett· January 2012

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Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H(3) receptor inverse agonists.
Ming Tao, Lisa D Aimone, John A Gruner, Joanne R Mathiasen, Zeqi Huang

Bioorg Med Chem Lett· January 2012

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