Publications by authors named "Lois Commodore"

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Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
Anna Kohlmann, Stephan G Zech, Feng Li, Tianjun Zhou, Rachel M Squillace, Lois Commodore

J Med Chem· February 2013

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Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.
Mathew Thomas, Wei-Sheng Huang, David Wen, Xiaotian Zhu, Yihan Wang, Lois Commodore

Bioorg Med Chem Lett· June 2011

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Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance.
Tianjun Zhou, Lois Commodore, Wei-Sheng Huang, Yihan Wang, Mathew Thomas

Chem Biol Drug Des· January 2011

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Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.
Wei-Sheng Huang, Chester A Metcalf, Raji Sundaramoorthi, Yihan Wang, Dong Zou, Lois Commodore

J Med Chem· June 2010

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Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
Tianjun Zhou, Lois Commodore, Wei-Sheng Huang, Yihan Wang, Tomi K Sawyer

Chem Biol Drug Des· January 2010

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AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.
Thomas O'Hare, William C Shakespeare, Xiaotian Zhu, Christopher A Eide, Victor M Rivera, Lois Commodore

Cancer Cell· November 2009

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Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces.
Youde Mo, Begoña Campos, Tanya R Mealy, Lois Commodore, James F Head

J Biol Chem· January 2003

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