Publications by authors named "Lon Cardon"

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Improving the predictive power of mouse models.
Martin Pera, Andy Greene, Lon Cardon, Gregory W Carter, Elissa J Chesler

Nat Biotechnol· August 2024

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Identifying therapeutic drug targets using bidirectional effect genes.
Karol Estrada, Steven Froelich, Arthur Wuster, Christopher R Bauer, Teague Sterling, Lon R Cardon

Nat Commun· April 2021

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Exome sequencing and characterization of 49,960 individuals in the UK Biobank.
Cristopher V Van Hout, Ioanna Tachmazidou, Joshua D Backman, Joshua D Hoffman, Daren Liu, Lon Cardon

Nature· October 2020

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Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study.
Lauren E Mokry, Sirui Zhou, Cong Guo, Robert A Scott, Luke Devey, Lon Cardon

Sci Rep· June 2019

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Characterization of ADME gene variation in 21 populations by exome sequencing.
Daniel H Hovelson, Zhengyu Xue, Matthew Zawistowski, Margaret G Ehm, Elizabeth C Harris, Lon R Cardon

Pharmacogenet Genomics· March 2017

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A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults.
Iona Y Millwood, Derrick A Bennett, Robin G Walters, Robert Clarke, Dawn Waterworth, Lon Cardon

Int J Epidemiol· October 2016

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Precision medicine, genomics and drug discovery.
Lon R Cardon, Tim Harris

Hum Mol Genet· October 2016

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Impact of genetically supported target selection on R&D productivity.
Mark R Hurle, Matthew R Nelson, Pankaj Agarwal, Lon R Cardon

Nat Rev Drug Discov· September 2016

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Trial watch: Impact of genetically supported target selection on R&D productivity.
Mark R Hurle, Matthew R Nelson, Pankaj Agarwal, Lon R Cardon

Nat Rev Drug Discov· August 2016

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Lipoprotein-Associated Phospholipase A2 Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults.
Iona Y Millwood, Derrick A Bennett, Robin G Walters, Robert Clarke, Dawn Waterworth, Lon Cardon

J Am Coll Cardiol· January 2016

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The support of human genetic evidence for approved drug indications.
Matthew R Nelson, Hannah Tipney, Jeffery L Painter, Judong Shen, Paola Nicoletti, Lon R Cardon

Nat Genet· August 2015

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Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib.
Michael L Maitland, Chun-Fang Xu, Yu-Ching Cheng, Emily Kistner-Griffin, Kathleen A Ryan, Lon R Cardon

Clin Cancer Res· January 2015

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Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury.
Daniel J Schaid, Colin F Spraggs, Shannon K McDonnell, Laura R Parham, Charles J Cox, Lon R Cardon

J Clin Oncol· August 2014

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Reply to Rational drug repositioning by medical genetics.
Philippe Sanseau, Pankaj Agarwal, Michael R Barnes, Tomi Pastinen, J Brent Richards, Lon R Cardon

Nat Biotechnol· December 2013

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Novelty in the target landscape of the pharmaceutical industry.
Pankaj Agarwal, Philippe Sanseau, Lon R Cardon

Nat Rev Drug Discov· August 2013

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Truncated robust distance for clinical laboratory safety data monitoring and assessment.
Xiwu Lin, Daniel Parks, Lei Zhu, Lloyd Curtis, Helen Steel, Lon Cardon

J Biopharm Stat· March 2013

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Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.
Justin P Rubio, Simon Topp, Liling Warren, Pamela L St Jean, Daniel Wegmann, Lon R Cardon

Hum Mutat· July 2012

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An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people.
Matthew R Nelson, Daniel Wegmann, Margaret G Ehm, Darren Kessner, Pamela St Jean, Lon R Cardon

Science· July 2012

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Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
Liling L Warren, Li Li, Matthew R Nelson, Margaret G Ehm, Judong Shen, Lon R Cardon

Diabetes· May 2012

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Use of genome-wide association studies for drug repositioning.
Philippe Sanseau, Pankaj Agarwal, Michael R Barnes, Tomi Pastinen, J Brent Richards, Lon R Cardon

Nat Biotechnol· April 2012

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An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
David R Owen, Astrid J Yeo, Roger N Gunn, Kijoung Song, Graham Wadsworth, Lon R Cardon

J Cereb Blood Flow Metab· January 2012

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The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.
Josine L Min, Jennifer M Taylor, J Brent Richards, Tim Watts, Fredrik H Pettersson, Lon R Cardon

PLoS One· November 2011

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Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes.
Chun-Fang Xu, Nan X Bing, Howard A Ball, Dilip Rajagopalan, Cora N Sternberg, Lon R Cardon

J Clin Oncol· June 2011

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Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.
Yangsoo Jang, Dawn Waterworth, Jong-Eun Lee, Kijoung Song, Sujin Kim, Lon Cardon

PLoS One· April 2011

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Basic statistical analysis in genetic case-control studies.
Geraldine M Clarke, Carl A Anderson, Fredrik H Pettersson, Lon R Cardon, Andrew P Morris

Nat Protoc· February 2011

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