Publications by authors named "Losee Ling"

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Novltex: A New Class of Antibiotics with Potent Activity against Multidrug-Resistant Bacterial Pathogens─Design, Synthesis, and Biological Evaluation.
Esra Malkawi, Anish Parmar, Sanjit Das, Enas Newire, Charlotte M Jones, Losee Lucy Ling

J Med Chem· September 2025

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Teixobactin: A Resistance-Evading Antibiotic for Treating Anthrax.
William S Lawrence, Jennifer E Peel, Rosan de Winter, Losee L Ling, Anthony G Nitti

ACS Infect Dis· March 2025

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A Resistance-Evading Antibiotic for Treating Anthrax.
Dallas Hughes, William Lawrence, Jennifer Peel, de Winter Rosan, Losee Ling

Res Sq· March 2024

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Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin.
Manas K Jagdev, Dharma R Tompa, Losee L Ling, Aaron J Peoples, Jagneshwar Dandapat

Int J Biol Macromol· December 2023

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An antibiotic from an uncultured bacterium binds to an immutable target.
Rhythm Shukla, Aaron J Peoples, Kevin C Ludwig, Sourav Maity, Maik G N Derks, Losee Lucy Ling

Cell· September 2023

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A new antibiotic from an uncultured bacterium binds to an immutable target.
Rhythm Shukla, Aaron J Peoples, Kevin C Ludwig, Sourav Maity, Maik G N Derks, Losee Lucy Ling

bioRxiv· May 2023

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Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29.
Maj Krumberger, Xingyue Li, Adam G Kreutzer, Aaron J Peoples, Anthony G Nitti, Losee L Ling

J Org Chem· February 2023

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Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Rhythm Shukla, Francesca Lavore, Sourav Maity, Maik G N Derks, Chelsea R Jones, Losee L Ling

Nature· August 2022

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Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin.
Daniel A Wirtz, Kevin C Ludwig, Melina Arts, Carina E Marx, Sebastian Krannich, Losee L Ling

Angew Chem Int Ed Engl· June 2021

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Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model.
William S Lawrence, Jennifer E Peel, Satheesh K Sivasubramani, Wallace B Baze, Elbert B Whorton, Losee L Ling

Pathogens· September 2020

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Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis.
Jeffrey Quigley, Aaron Peoples, Asel Sarybaeva, Dallas Hughes, Meghan Ghiglieri, Losee Lucy Ling

mBio· August 2020

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In situ cultivation of previously uncultivable microorganisms using the ichip.
Brittany Berdy, Amy L Spoering, Losee L Ling, Slava S Epstein

Nat Protoc· October 2017

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Reducing the Bottleneck in Discovery of Novel Antibiotics.
Marcus B Jones, William C Nierman, Yue Shan, Bryan C Frank, Amy Spoering, Losee Ling

Microb Ecol· April 2017

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Erratum: A new antibiotic kills pathogens without detectable resistance.
Losee L Ling, Tanja Schneider, Aaron J Peoples, Amy L Spoering, Ina Engels

Nature· April 2015

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A new antibiotic kills pathogens without detectable resistance.
Losee L Ling, Tanja Schneider, Aaron J Peoples, Amy L Spoering, Ina Engels

Nature· January 2015

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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Ekaterina Gavrish, Clarissa S Sit, Shugeng Cao, Olga Kandror, Amy Spoering, Losee Ling

Chem Biol· April 2014

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Uncultured microorganisms as a source of secondary metabolites.
Kim Lewis, Slava Epstein, Anthony D'Onofrio, Losee L Ling

J Antibiot (Tokyo)· August 2010

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Isofuranonaphthoquinone produced by an Actinoplanes isolate.
Qibo Zhang, Aaron J Peoples, Mithra T Rothfeder, William P Millett, Brian C Pescatore, Losee L Ling

J Nat Prod· June 2009

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Neocitreamicins I and II, novel antibiotics with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.
Aaron J Peoples, Qibo Zhang, William P Millett, Mithra T Rothfeder, Brian C Pescatore, Losee L Ling

J Antibiot (Tokyo)· July 2008

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Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase.
Losee L Ling, Jun Xian, Syed Ali, Bolin Geng, Jun Fan

Antimicrob Agents Chemother· May 2004

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The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells.
Aoy Tomita-Mitchell, Losee Lucy Ling, Curtis L Glover, Jacklene Goodluck-Griffith, William G Thilly

Cancer Res· September 2003

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Microbial pathogen genomes - new strategies for identifying therapeutic and vaccine targets.
Timothy Opperman, Losee L Ling, Donald T Moir

Expert Opin Ther Targets· August 2003

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