Publications by authors named "Louis R Ghanem"

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Artificial Intelligence-Enabled Clinical Trials in Inflammatory Bowel Disease: Automating and Enhancing Disease Assessment and Study Management.
Ryan W Stidham, Louis R Ghanem, Joel G Fletcher, David H Bruining

Gastroenterology· August 2025

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RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation.
Matthew W Haemmerle, Kirill Batmanov, Sabyasachi Sen, Matthew J Varney, Alexander T Utecht, Louis R Ghanem

Mol Metab· August 2025

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Artificial Intelligence for Quantifying Endoscopic Mucosal Ulceration in Crohn's Disease.
Lingrui Cai, Emily Wittrup, Cristian Minoccheri, Tadd K Hiatt, Michael D Rice, Louis R Ghanem

Clin Gastroenterol Hepatol· August 2025

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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Louis R Ghanem

Elife· January 2025

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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Louis R Ghanem

medRxiv· August 2024

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RNA-binding protein PCBP2 regulates pancreatic β cell function and adaptation to glucose.
Matthew W Haemmerle, Andrea V Scota, Mina Khosravifar, Matthew J Varney, Sabyasachi Sen, Louis R Ghanem

J Clin Invest· June 2024

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Deep Learning Models Capture Histological Disease Activity in Crohn's Disease and Ulcerative Colitis with High Fidelity.
Dawid Rymarczyk, Weiwei Schultz, Adriana Borowa, Joshua R Friedman, Tomasz Danel, Louis R Ghanem

J Crohns Colitis· April 2024

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Using Computer Vision to Improve Endoscopic Disease Quantification in Therapeutic Clinical Trials of Ulcerative Colitis.
Ryan W Stidham, Lingrui Cai, Shuyang Cheng, Flora Rajaei, Tadd Hiatt, Louis R Ghanem

Gastroenterology· January 2024

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The poly(C)-binding protein Pcbp2 is essential for CD4 T cell activation and proliferation.
Massimo Martinelli, Gabrielle Aguilar, David S M Lee, Andrew Kromer, Nhu Nguyen, Louis R Ghanem

iScience· January 2023

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Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease.
Chiara Lasconi, Matthew C Pahl, Diana L Cousminer, Claudia A Doege, Alessandra Chesi, Louis R Ghanem

Cell Mol Gastroenterol Hepatol· December 2021

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CYP11B1 variants influence skeletal maturation via alternative splicing.
Olja Grgic, Matthew R Gazzara, Alessandra Chesi, Carolina Medina-Gomez, Diana L Cousminer, Louis R Ghanem

Commun Biol· November 2021

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RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.
Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R Ghanem, Andrew Kromer

Mol Cell Biol· August 2021

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Disrupting upstream translation in mRNAs is associated with human disease.
David S M Lee, Joseph Park, Andrew Kromer, Aris Baras, Daniel J Rader, Louis R Ghanem

Nat Commun· March 2021

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Lactate Limits T Cell Proliferation via the NAD(H) Redox State.
William J Quinn, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Louis R Ghanem

Cell Rep· December 2020

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Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations.
David S M Lee, Louis R Ghanem, Yoseph Barash

Nat Commun· January 2020

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The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.
Deanne M Taylor, Bruce J Aronow, Kai Tan, Kathrin Bernt, Nathan Salomonis, Louis R Ghanem

Dev Cell· April 2019

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Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.
Louis R Ghanem, Andrew Kromer, Ian M Silverman, Xinjun Ji, Matthew Gazzara

Mol Cell Biol· August 2018

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The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
Louis R Ghanem, Andrew Kromer, Ian M Silverman, Priya Chatterji, Elizabeth Traxler

Mol Cell Biol· January 2016

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Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa.
Louis R Ghanem, Priya Chatterji, Stephen A Liebhaber

Gene Expr Patterns· March 2014

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