Publications by authors named "Luca Lotta"

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Effect of PCSK9 Inhibition With Alirocumab in Patients With Probable Familial Hypercholesterolemia or Type III Hyperlipoproteinemia: Results From the ODYSSEY OUTCOMES Trial.
Gregory P Geba, Kusha A Mohammadi, Amy Damask, Charles Paulding, Luca A Lotta

J Am Heart Assoc· September 2025

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Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways.
Marijana Vujkovic, David E Kaplan, Jonas Ghouse, Bao-Li Loza, Joseph Brancale, Luca A Lotta

medRxiv· September 2025

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Thrombotic risk determined by CREB3L1 variants in a population-based cohort study: linkage disequilibrium with prothrombin mutation.
Eric Manderstedt, Christer Halldén, Christina Lind-Halldén, Johan Elf, Peter J Svensson, Luca A Lotta

J Thromb Haemost· July 2025

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A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework.
Aaron Hakim, Kung-Hung Lin, Tae-Hwi Schwantes-An, Marco Abreu, Jingyi Tan, Luca Lotta

Hepatol Commun· June 2025

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Translational genomics of osteoarthritis in 1,962,069 individuals.
Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefansdottir, Cindy G Boer, Merry-Lynn McDonald, Luca Lotta

Nature· May 2025

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Thrombotic risk determined by , , and variants in a population-based cohort study.
Eric Manderstedt, Christer Halldén, Christina Lind-Halldén, Johan Elf, Peter J Svensson, Luca A Lotta

Res Pract Thromb Haemost· May 2025

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Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.
Carolina Roselli, Ida Surakka, Morten S Olesen, Gardar Sveinbjornsson, Nicholas A Marston, Luca Lotta

Nat Genet· March 2025

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Deficiency of Peptidylglycine-alpha-amidating Monooxygenase, a Cause of Sarcopenic Diabetes Mellitus.
Alice Giontella, Mikael Åkerlund, Kevin Bronton, Cristiano Fava, Luca A Lotta

J Clin Endocrinol Metab· February 2025

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Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.
Hongbo Liu, Amin Abedini, Eunji Ha, Ziyuan Ma, Xin Sheng, Luca A Lotta

Science· February 2025

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Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Luca A Lotta

Nature· January 2025

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Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.
Shek Man Chim, Kristen Howell, John Dronzek, Weizhen Wu, Cristopher Van Hout, Luca Lotta

Elife· December 2024

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Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank.
Sheila M Gaynor, Tyler Joseph, Xiaodong Bai, Yuxin Zou, Boris Boutkov, Luca A Lotta

Nat Genet· November 2024

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Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone.
Michael E Dunn, Aaron Kithcart, Jee Hae Kim, Andre Jo-Hao Ho, Matthew C Franklin, Luca A Lotta

Nature· September 2024

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NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and associated with stroke.
Juan Lorenzo Rodriguez-Flores, Shareef Khalid, Neelroop Parikshak, Asif Rasheed, Bin Ye, Luca A Lotta

Nat Commun· September 2024

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Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk.
Oliver B Vad, Laia M Monfort, Christian Paludan-Müller, Konstantin Kahnert, Søren Z Diederichsen, Luca A Lotta

JAMA Cardiol· August 2024

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Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.
Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Luca Lotta

Nat Genet· May 2024

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SERPINH1 variants and thrombotic risk among middle-aged and older adults: a population-based cohort study.
Eric Manderstedt, Christina Lind-Halldén, Christer Halldén, Johan Elf, Peter J Svensson, Luca A Lotta

J Thromb Haemost· March 2024

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Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.
Eriks Smagris, Lisa M Shihanian, Ivory J Mintah, Parnian Bigdelou, Yuliya Livson, Luca A Lotta

PLoS Genet· March 2024

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Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis.
Patrick R Lawler, Garen Manvelian, Alida Coppi, Amy Damask, Michael N Cantor, Luca A Lotta

Crit Care Explor· November 2023

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Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.
Rene C Adam, Dwaine S Pryce, Joseph S Lee, Yuanqi Zhao, Ivory J Mintah, Luca A Lotta

Proc Natl Acad Sci U S A· August 2023

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Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis.
Sirui Zhou, Olukayode A Sosina, Jonas Bovijn, Laetitia Laurent, Vasundhara Sharma, Luca A Lotta

Nat Genet· August 2023

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Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Luca A Lotta

Nature· March 2023

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Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Luca A Lotta

Nature· December 2022

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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Luca A Lotta

Nat Genet· December 2022

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Genetic variation of the blood coagulation regulator tissue factor pathway inhibitor and venous thromboembolism among middle-aged and older adults: A population-based cohort study.
Eric Manderstedt, Christina Lind-Halldén, Christer Halldén, Johan Elf, Peter J Svensson, Luca A Lotta

Res Pract Thromb Haemost· October 2022

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