Publications by authors named "Lucy Waskell"

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Similar Rates of Second Electron Transfer and Single-Turnover Dehydroepiandrosterone Formation for Oxyferrous Human Cytochrome P450 17A1 (Steroid 17-Hydroxylase/17,20-lyase)-17-hydroxypregnenolone Complex with Either Human Cytochrome P450-Oxidoreductase or Human Cytochrome .
Sang-Choul Im, Hwei-Ming Peng, Lucy Waskell, Richard J Auchus

Biochemistry· May 2025

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A flexible linker of 8-amino acids between the membrane binding segment and the FMN domain of cytochrome P450 reductase is necessary for optimal activity.
Freeborn Rwere, Naw May P Cartee, Yuting Yang, Lucy Waskell

J Inorg Biochem· October 2024

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The FMN "140s Loop" of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450.
Freeborn Rwere, Sangchoul Im, Lucy Waskell

Int J Mol Sci· September 2021

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Expression, purification, and functional reconstitution of F-labeled cytochrome b5 in peptide nanodiscs for NMR studies.
Jia Bai, Jian Wang, Thirupathi Ravula, Sang-Choul Im, G M Anantharamaiah, Lucy Waskell

Biochim Biophys Acta Biomembr· May 2020

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Structure of cytochrome P450 2B4 with an acetate ligand and an active site hydrogen bond network similar to oxyferrous P450cam.
Yuting Yang, Weishu Bu, Sangchoul Im, Jennifer Meagher, Jeanne Stuckey, Lucy Waskell

J Inorg Biochem· August 2018

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Effect of polymer charge on functional reconstitution of membrane proteins in polymer nanodiscs.
Thirupathi Ravula, Nathaniel Z Hardin, Jia Bai, Sang-Choul Im, Lucy Waskell

Chem Commun (Camb)· August 2018

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A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs.
Elke Prade, Mukesh Mahajan, Sang-Choul Im, Meng Zhang, Katherine A Gentry, Lucy Waskell

Angew Chem Int Ed Engl· July 2018

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Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase.
Carlo Barnaba, Thirupathi Ravula, Ilce G Medina-Meza, Sang-Choul Im, G M Anantharamaiah, Lucy Waskell

Chem Commun (Camb)· June 2018

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Substrate mediated redox partner selectivity of cytochrome P450.
Katherine A Gentry, Meng Zhang, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy

Chem Commun (Camb)· May 2018

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Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs.
Carlo Barnaba, Bikash Ranjan Sahoo, Thirupathi Ravula, Ilce G Medina-Meza, Sang-Choul Im, Lucy Waskell

Angew Chem Int Ed Engl· March 2018

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Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
Chuanwu Xia, Freeborn Rwere, Sangchoul Im, Anna L Shen, Lucy Waskell

Biochemistry· February 2018

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Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b.
Thirupathi Ravula, Carlo Barnaba, Mukesh Mahajan, G M Anantharamaiah, Sang-Choul Im, Lucy Waskell

Chem Commun (Camb)· November 2017

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Kinetic and Structural Characterization of the Effects of Membrane on the Complex of Cytochrome b and Cytochrome c.
Katherine A Gentry, Elke Prade, Carlo Barnaba, Meng Zhang, Mukesh Mahajan, Lucy Waskell

Sci Rep· August 2017

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Transmembrane Interactions of Full-length Mammalian Bitopic Cytochrome-P450-Cytochrome-b Complex in Lipid Bilayers Revealed by Sensitivity-Enhanced Dynamic Nuclear Polarization Solid-state NMR Spectroscopy.
Kazutoshi Yamamoto, Marc A Caporini, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy

Sci Rep· June 2017

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Protonation of the Hydroperoxo Intermediate of Cytochrome P450 2B4 Is Slower in the Presence of Cytochrome P450 Reductase Than in the Presence of Cytochrome b5.
Naw May Pearl, Jarett Wilcoxen, Sangchoul Im, Ryan Kunz, Joseph Darty, Lucy Waskell

Biochemistry· November 2016

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Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.
Hwei-Ming Peng, Sang-Choul Im, Naw May Pearl, Adina F Turcu, Juilee Rege, Lucy Waskell

Biochemistry· August 2016

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Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
Freeborn Rwere, Chuanwu Xia, Sangchoul Im, Mohammad M Haque, Dennis J Stuehr, Lucy Waskell

J Biol Chem· July 2016

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Reconstitution of the Cytb5-CytP450 Complex in Nanodiscs for Structural Studies using NMR Spectroscopy.
Meng Zhang, Rui Huang, Rose Ackermann, Sang-Choul Im, Lucy Waskell

Angew Chem Int Ed Engl· March 2016

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Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Double Resonance Spectroscopy.
Roman Davydov, Sangchoul Im, Muralidharan Shanmugam, William A Gunderson, Naw May Pearl, Lucy Waskell

Biochemistry· February 2016

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Effects of membrane mimetics on cytochrome P450-cytochrome b5 interactions characterized by NMR spectroscopy.
Meng Zhang, Rui Huang, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy

J Biol Chem· May 2015

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Kinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c.
Rui Huang, Meng Zhang, Freeborn Rwere, Lucy Waskell, Ayyalusamy Ramamoorthy

J Biol Chem· February 2015

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Temperature-resistant bicelles for structural studies by solid-state NMR spectroscopy.
Kazutoshi Yamamoto, Paige Pearcy, Dong-Kuk Lee, Changsu Yu, Sang-Choul Im, Lucy Waskell

Langmuir· February 2015

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Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR.
Meng Zhang, Stéphanie V Le Clair, Rui Huang, Shivani Ahuja, Sang-Choul Im, Lucy Waskell

Sci Rep· February 2015

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Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.
Mohammad M Haque, Mekki Bayachou, Jesus Tejero, Claire T Kenney, Naw M Pearl, Lucy Waskell

FEBS J· December 2014

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Structural and functional characterization of a cytochrome P450 2B4 F429H mutant with an axial thiolate-histidine hydrogen bond.
Yuting Yang, Haoming Zhang, Dandamudi Usharani, Weishu Bu, Sangchoul Im, Lucy Waskell

Biochemistry· August 2014

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