Publications by authors named "Ludovic Jean"

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Assessment of cytotoxic properties of tetrahydroisoquinoline oximes in breast, prostate and glioblastoma cancer cells.
Antonio Zandona, Matea Jurić, Ludovic Jean, Pierre-Yves Renard, Maja Katalinić

Drug Chem Toxicol· July 2025

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Synthesis and Evaluation of the Photochemical Properties of Heterocyclic Hemiindigos.
Aurélie Gernet, Louise-Marie Balivet, Ahmed El Rhaz, Lucas Pagès, Guillaume Laurent, Ludovic Jean

Chemistry· May 2025

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Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases.
Dora Kolić, Goran Šinko, Ludovic Jean, Mourad Chioua, José Dias

Biomolecules· May 2024

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Easily Accessible Substituted Heterocyclic Hemithioindigos as Bistable Molecular Photoswitches.
Aurélie Gernet, Ahmed El Rhaz, Ludovic Jean

Chemistry· August 2023

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Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells.
Antonio Zandona, Josip Madunić, Katarina Miš, Nikola Maraković, Pierre Dubois-Geoffroy, Ludovic Jean

Toxicology· August 2023

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A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
Ophélie Da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, Ludovic Jean

J Med Chem· March 2022

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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.
Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Pedro Cisternas, Carolina A Oliva, Ludovic Jean

J Med Chem· January 2021

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Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor.
Monika Cieslikiewicz-Bouet, Marina Naldi, Manuela Bartolini, Belén Pérez, Denis Servent, Ludovic Jean

Biochem Pharmacol· July 2020

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Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning.
Tamara Zorbaz, Petra Mišetić, Nicolas Probst, Suzana Žunec, Antonio Zandona, Ludovic Jean

ACS Chem Neurosci· April 2020

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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Killian Oukoloff, Nicolas Coquelle, Manuela Bartolini, Marina Naldi, Rémy Le Guevel, Ludovic Jean

Eur J Med Chem· April 2019

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Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles.
Pierrick Bruyat, Arnaud Gautier, Ludovic Jean, Pierre-Yves Renard

J Org Chem· November 2018

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Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection.
Tatiana N Pashirova, Anissa Braïki, Irina V Zueva, Konstantin A Petrov, Vasily M Babaev, Ludovic Jean

J Control Release· November 2018

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Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.
Gianluca Santoni, Julien de Sousa, Eugenio de la Mora, José Dias, Ludovic Jean

J Med Chem· September 2018

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Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.
Tamara Zorbaz, Anissa Braïki, Nikola Maraković, Julien Renou, Eugenio de la Mora, Ludovic Jean

Chemistry· July 2018

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Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.
Carles Galdeano, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Manuela Bartolini, Belén Pérez, Ludovic Jean

Molecules· March 2018

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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox.
Paul Hermant, Damien Bosc, Catherine Piveteau, Ronan Gealageas, BaoVy Lam, Ludovic Jean

J Med Chem· November 2017

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An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.
André-Guilhem Calas, José Dias, Catherine Rousseau, Mélanie Arboléas, Mélanie Touvrey-Loiodice, Ludovic Jean

Chem Biol Interact· April 2017

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Probing the cholinergic system to understand neurodegenerative diseases.
Pierre-Yves Renard, Ludovic Jean

Future Med Chem· January 2017

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A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging.
Sovy Chao, Eric Krejci, Véronique Bernard, Jacqueline Leroy, Ludovic Jean

Chem Commun (Camb)· October 2016

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PET and SPECT Radiotracers for Alzheimer's Disease.
Killian Oukoloff, Monika Cieslikiewicz-Bouet, Sovy Chao, Emilie Da Costa Branquinho, Cedric Bouteiller, Ludovic Jean

Curr Med Chem· April 2016

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Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.
Lucie Aliouane, Sovy Chao, Leyre Brizuela, Emmanuel Pfund, Olivier Cuvillier, Ludovic Jean

Bioorg Med Chem· September 2014

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Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.
Maria Kliachyna, Gianluca Santoni, Valentin Nussbaum, Julien Renou, Benoit Sanson, Ludovic Jean

Eur J Med Chem· May 2014

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Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases.
Julien Renou, Mélanie Loiodice, Mélanie Arboléas, Rachid Baati, Ludovic Jean

Chem Commun (Camb)· April 2014

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Reaction site-driven regioselective synthesis of AChE inhibitors.
Emilia Oueis, Gianluca Santoni, Cyril Ronco, Olga Syzgantseva, Vincent Tognetti, Ludovic Jean

Org Biomol Chem· January 2014

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Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
Florian Nachon, Eugénie Carletti, Cyril Ronco, Marie Trovaslet, Yvain Nicolet, Ludovic Jean

Biochem J· August 2013

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