Publications by authors named "Luis Sojo"

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The Pharmacokinetic and Pharmacodynamic Relationship of Clinically Used Antiseizure Medications in the Maximal Electroshock Seizure Model in Rodents.
Luis Bettio, Girish Bankar, Celine M Dubé, Karen Nelkenbrecher, Maja Filipovic, Luis Sojo

Int J Mol Sci· July 2025

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The contribution of Na1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na1.6 gain-of-function (GOF) mouse seizure control.
James P Johnson, Thilo Focken, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Luis Sojo

Br J Pharmacol· October 2024

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Development and application of a multiple reaction monitoring method for the simultaneous quantification of sodium channels Na 1.1, Na 1.2, and Na 1.6 in solubilized membrane proteins from stable HEK293 cell lines, rodents, and human brain tissues.
Rainbow Kwan, Prerna Das, Neelan Gerrebos, Jenny Li, Xin Yin Wang, Luis E Sojo

Rapid Commun Mass Spectrom· February 2024

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Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation.
Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Luis Sojo

J Pharmacol Exp Ther· July 2023

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NBI-921352, a first-in-class, Na1.6 selective, sodium channel inhibitor that prevents seizures in gain-of-function mice, and wild-type mice and rats.
J P Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Luis Sojo

Elife· March 2022

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Identification of aryl sulfonamides as novel and potent inhibitors of Na1.5.
Shaoyi Sun, Qi Jia, Alla Y Zenova, Sophia Lin, Angela Hussainkhel, Luis Sojo

Bioorg Med Chem Lett· August 2021

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Discovery of Acyl-sulfonamide Na1.7 Inhibitors GDC-0276 and GDC-0310.
Brian S Safina, Steven J McKerrall, Shaoyi Sun, Chien-An Chen, Sultan Chowdhury, Luis Sojo

J Med Chem· March 2021

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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.
Thilo Focken, Kristen Burford, Michael E Grimwood, Alla Zenova, Jean-Christophe Andrez, Luis Sojo

J Med Chem· November 2019

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On the feasibility of quantifying sodium channel Na 1.6 protein in mouse brain using targeted ultra-high-performance/electrospray ionization multiple reaction monitoring mass spectrometry.
Luis E Sojo, Rainbow Kwan, Cathy Dang, Matthew Tung, Jenny Li

Rapid Commun Mass Spectrom· April 2019

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Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na) 1.7 with Potent Analgesic Activity.
Shaoyi Sun, Qi Jia, Alla Y Zenova, Michael S Wilson, Sultan Chowdhury, Luis Sojo

J Med Chem· January 2019

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Selective Na1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.
Girish Bankar, Samuel J Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Luis E Sojo

Cell Rep· September 2018

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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa1.7 Inhibitors for the Treatment of Pain.
Thilo Focken, Sultan Chowdhury, Alla Zenova, Michael E Grimwood, Christine Chabot, Luis Sojo

J Med Chem· June 2018

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2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 1 - small molecules by LCMS).
Jan Welink, Eric Fluhler, Nicola Hughes, Mark Arnold, Fabio Garofolo, Luis Sojo

Bioanalysis· September 2016

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Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
Thilo Focken, Shifeng Liu, Navjot Chahal, Maxim Dauphinais, Michael E Grimwood, Luis E Sojo

ACS Med Chem Lett· March 2016

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Oxidation of catechols during positive ion electrospray mass spectrometric analysis: evidence for in-source oxidative dimerization.
Luis E Sojo, Navjot Chahal, Bernd O Keller

Rapid Commun Mass Spectrom· October 2014

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Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.
Shaoyi Sun, Richard Dean, Qi Jia, Alla Zenova, Jing Zhong, Luis Sojo

Bioorg Med Chem· December 2013

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The use of multiplexed MRM for the discovery of biomarkers to differentiate iron-deficiency anemia from anemia of inflammation.
Dominik Domanski, Gabriela V Cohen Freue, Luis Sojo, Michael A Kuzyk, Leslie Ratkay

J Proteomics· June 2012

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Internal standard signal suppression by co-eluting analyte in isotope dilution LC-ESI-MS.
Luis E Sojo, Gina Lum, Priscilla Chee

Analyst· January 2003

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