Publications by authors named "Luis Tecedor"

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An AAV variant selected through NHP screens robustly transduces the brain and drives secreted protein expression in NHPs and mice.
Luis Tecedor, Yong Hong Chen, David E Leib, Paul T Ranum, Megan S Keiser

Sci Transl Med· May 2025

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APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.
Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Luis Tecedor

Mol Ther· May 2024

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-derived ependyma promoter drives increased therapeutic protein secretion into the CSF.
Ellie M Carrell, Yong Hong Chen, Paul T Ranum, Stephanie L Coffin, Larry N Singh, Luis Tecedor

Mol Ther Nucleic Acids· September 2023

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APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.
Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Luis Tecedor

bioRxiv· August 2023

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Cochlear transduction via cerebrospinal fluid delivery of AAV in non-human primates.
Paul T Ranum, Luis Tecedor, Megan S Keiser, Yong Hong Chen, David E Leib

Mol Ther· March 2023

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Neuronal genetic rescue normalizes brain network dynamics in a lysosomal storage disorder despite persistent storage accumulation.
Rebecca C Ahrens-Nicklas, Luis Tecedor, Arron F Hall, Owen Kane, Richard J Chung

Mol Ther· July 2022

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Author Correction: Regulated control of gene therapies by drug-induced splicing.
Alex Mas Monteys, Amiel A Hundley, Paul T Ranum, Luis Tecedor, Amy Muehlmatt

Nature· February 2022

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Regulated control of gene therapies by drug-induced splicing.
Alex Mas Monteys, Amiel A Hundley, Paul T Ranum, Luis Tecedor, Amy Muehlmatt

Nature· August 2021

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Neuronal network dysfunction precedes storage and neurodegeneration in a lysosomal storage disorder.
Rebecca C Ahrens-Nicklas, Luis Tecedor, Arron F Hall, Elena Lysenko, Akiva S Cohen

JCI Insight· November 2019

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Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo.
Genevieve Beauvais, Jaime L Watson, Jose A Aguirre, Luis Tecedor, Michelle E Ehrlich

Brain Res· March 2019

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Modulating membrane fluidity corrects Batten disease phenotypes in vitro and in vivo.
Mark L Schultz, Luis Tecedor, Elena Lysenko, Shyam Ramachandran, Colleen S Stein

Neurobiol Dis· July 2018

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Overcoming Limitations Inherent in Sulfamidase to Improve Mucopolysaccharidosis IIIA Gene Therapy.
Yonghong Chen, Shujuan Zheng, Luis Tecedor, Beverly L Davidson

Mol Ther· April 2018

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AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease.
Martin L Katz, Luis Tecedor, Yonghong Chen, Baye G Williamson, Elena Lysenko

Sci Transl Med· November 2015

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CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.
Mark L Schultz, Luis Tecedor, Colleen S Stein, Mark A Stamnes, Beverly L Davidson

PLoS One· June 2015

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Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.
John H Lee, Luis Tecedor, Yong Hong Chen, Alex Mas Monteys, Matthew J Sowada

Neuron· January 2015

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CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells.
Luis Tecedor, Colleen S Stein, Mark L Schultz, Hany Farwanah, Konrad Sandhoff

J Neurosci· November 2013

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Clarifying lysosomal storage diseases.
Mark L Schultz, Luis Tecedor, Michael Chang, Beverly L Davidson

Trends Neurosci· August 2011

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A knock-in reporter mouse model for Batten disease reveals predominant expression of Cln3 in visual, limbic and subcortical motor structures.
Song-Lin Ding, Luis Tecedor, Colleen S Stein, Beverly L Davidson

Neurobiol Dis· February 2011

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Structure and activity of putative intronic miRNA promoters.
Alex Mas Monteys, Ryan M Spengler, Ji Wan, Luis Tecedor, Kimberly A Lennox

RNA· March 2010

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A knock-in reporter model of Batten disease.
Steven L Eliason, Colleen S Stein, Qinwen Mao, Luis Tecedor, Song-Lin Ding

J Neurosci· September 2007

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