Publications by authors named "Luke A Gilbert"

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Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer.
Haolong Li, James E Melnyk, Becky Xu Hua Fu, Raunak Shrestha, Meng Zhang, Luke A Gilbert

Nat Genet· December 2025

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Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis.
Becky Xu Hua Fu, Albert Xu, Hua Li, Daniel E Johnson, Jennifer R Grandis, Luke A Gilbert

Cell Death Dis· November 2025

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Site-specific DNA insertion into the human genome with engineered recombinases.
Alison Fanton, Liam J Bartie, Juliana Q Martins, Vincent Q Tran, Laine Goudy, Luke A Gilbert

Nat Biotechnol· November 2025

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FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.
Jennifer M Umhoefer, Maya M Arce, Sivakanthan Kasinathan, Sean Whalen, Rama Dajani, Luke A Gilbert

Immunity· November 2025

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Integrated epigenetic and genetic programming of primary human T cells.
Laine Goudy, Alvin Ha, Ashir A Borah, Jennifer M Umhoefer, Lauren Chow, Luke A Gilbert

Nat Biotechnol· October 2025

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Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy.
Katie Lin, Christopher Zou, Akane Hubbard, Sasha Sengelmann, Laine Goudy, Luke A Gilbert

Neuro Oncol· July 2025

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Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.
Tianyi Liu, Meng Zhang, Tatyanah Farsh, Haolong Li, Audrey Kishishita, Luke A Gilbert

Nat Commun· July 2025

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Virtual Cell Challenge: Toward a Turing test for the virtual cell.
Yusuf H Roohani, Tony J Hua, Po-Yuan Tung, Lexi R Bounds, Feiqiao B Yu, Luke A Gilbert

Cell· June 2025

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Neddylation as a target in PIK3CA-mutated head and neck cancer.
Shorook Naara, Zhibin Cui, Adila Izgutdina, Nathan K VanLandingham, Andrew Nazarenko, Luke A Gilbert

Biochem Biophys Res Commun· May 2025

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Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator.
Haolong Li, James E Melnyk, Becky Xu Hua Fu, Raunak Shrestha, Meng Zhang, Luke A Gilbert

bioRxiv· May 2025

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EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs.
Hyerim Yi, Shu Zhang, Jason Swinderman, Yanbo Wang, Vishnupriya Kanakaveti, Luke A Gilbert

bioRxiv· April 2025

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Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer.
Lisa N Chesner, Fanny Polesso, Julie N Graff, Jessica E Hawley, Alexis K Smith, Luke A Gilbert

Cancer Discov· March 2025

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MorPhiC Consortium: towards functional characterization of all human genes.
Mazhar Adli, Laralynne Przybyla, Tony Burdett, Paul W Burridge, Pilar Cacheiro, Luke A Gilbert

Nature· February 2025

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Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3.
Jennifer M Umhoefer, Maya M Arce, Sean Whalen, Rama Dajani, Laine Goudy, Luke A Gilbert

bioRxiv· January 2025

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Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis.
Becky Xu Hua Fu, Albert Xu, Hua Li, Daniel E Johnson, Jennifer R Grandis, Luke A Gilbert

bioRxiv· January 2025

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In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.
S John Liu, Christopher Zou, Joanna Pak, Alexandra Morse, Dillon Pang, Luke A Gilbert

Genome Biol· October 2024

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A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation.
Alex Y Ge, Abolfazl Arab, Raymond Dai, Albertas Navickas, Lisa Fish, Luke A Gilbert

Sci Rep· October 2024

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Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry.
Caroline M Wilson, Greg C Pommier, Daniel D Richman, Nicholas Sambold, Jeffrey A Hussmann, Luke A Gilbert

bioRxiv· October 2024

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A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.
Marine Berquez, Alexander L Li, Matthew A Luy, Anthony C Venida, Thomas O'Loughlin, Luke A Gilbert

bioRxiv· October 2024

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A systematic search for RNA structural switches across the human transcriptome.
Matvei Khoroshkin, Daniel Asarnow, Shaopu Zhou, Albertas Navickas, Aidan Winters, Luke A Gilbert

Nat Methods· September 2024

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Integrative identification of non-coding regulatory regions driving metastatic prostate cancer.
Brian J Woo, Ruhollah Moussavi-Baygi, Heather Karner, Mehran Karimzadeh, Hassan Yousefi, Luke A Gilbert

Cell Rep· September 2024

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Improving prime editing with an endogenous small RNA-binding protein.
Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar, Carl C Ward, Sébastien Levesque, Luke A Gilbert

Nature· April 2024

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Base-editing mutagenesis maps alleles to tune human T cell functions.
Ralf Schmidt, Carl C Ward, Rama Dajani, Zev Armour-Garb, Mineto Ota, Luke A Gilbert

Nature· January 2024

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ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer.
Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Gemini Skariah, Luke A Gilbert

Proc Natl Acad Sci U S A· December 2023

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Environmental challenge rewires functional connections among human genes.
Benjamin W Herken, Garrett T Wong, Thomas M Norman, Luke A Gilbert

bioRxiv· August 2023

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