Publications by authors named "Luke Chamberlain"

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Different chains for different gains: How acyl chain diversity shapes S-acylated protein function.
Carla Busquets Hernández, Alexandra Tsiotsia, Ludovico Pipitò, Luke H Chamberlain, Jennifer Greaves

Prog Lipid Res· November 2025

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Evaluating Policy Changes for Adjusting Payment to Address Health Disparities.
W Ryan Powell, Luke Chamberlain, William R Buckingham, Ying Cao, Mariétou H Ouayogodé

JAMA Health Forum· September 2024

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Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the -acylation machinery.
Carla Busquets-Hernández, Silvia Ribó, Esther Gratacós-Batlle, Daniel Carbajo, Alexandra Tsiotsia, Luke H Chamberlain

Chem Sci· August 2024

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The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins.
Christine Salaun, Nicholas C O Tomkinson, Luke H Chamberlain

J Biol Chem· October 2023

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A Monitoring System for Carbon Dioxide in Honeybee Hives: An Indicator of Colony Health.
Martin Bencsik, Adam McVeigh, Costas Tsakonas, Tarun Kumar, Luke Chamberlain

Sensors (Basel)· March 2023

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S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.
Liam Butler, Carolina Locatelli, Despoina Allagioti, Irina Lousa, Kimon Lemonidis, Luke H Chamberlain

J Biol Chem· January 2023

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Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation.
Christine Salaun, Hiroya Takizawa, Alex Galindo, Kevin R Munro, Jayde McLellan, Luke H Chamberlain

J Biol Chem· October 2022

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The Hydrophobic Cysteine-rich Domain of SNAP25 Couples with Downstream Residues to Mediate Membrane Interactions and Recognition by DHHC Palmitoyl Transferases.
Jennifer Greaves, Gerald R Prescott, Yuko Fukata, Masaki Fukata, Christine Salaun, Luke H Chamberlain

Mol Biol Cell· September 2022

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Regulatory effects of protein S-acylation on insulin secretion and insulin action.
Luke H Chamberlain, Michael J Shipston, Gwyn W Gould

Open Biol· March 2021

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Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2.
Carolina Locatelli, Kimon Lemonidis, Christine Salaun, Nicholas C O Tomkinson, Luke H Chamberlain

J Cell Sci· November 2020

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Accessory proteins of the zDHHC family of S-acylation enzymes.
Christine Salaun, Carolina Locatelli, Filip Zmuda, Juan Cabrera González, Luke H Chamberlain

J Cell Sci· November 2020

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Regulatory effects of post-translational modifications on zDHHC -acyltransferases.
Filip Zmuda, Luke H Chamberlain

J Biol Chem· October 2020

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The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation.
Christine Salaun, Jennifer Greaves, Nicholas C O Tomkinson, Luke H Chamberlain

J Biol Chem· May 2020

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Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse model.
Marianna Kouskou, David M Thomson, Ros R Brett, Lee Wheeler, Rothwelle J Tate, Luke H Chamberlain

Exp Neurol· October 2018

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Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.
Loic Fort, José Miguel Batista, Peter A Thomason, Heather J Spence, Jamie A Whitelaw, Luke H Chamberlain

Nat Cell Biol· October 2018

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S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19.
Khamal K Ampah, Jennifer Greaves, Amber S Shun-Shion, Asral W Asnawi, Jessica A Lidster, Luke H Chamberlain

J Cell Sci· October 2018

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LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein.
Linda Sutherland, Madeleine Ruhe, Daniela Gattegno-Ho, Karanjit Mann, Jennifer Greaves, Luke H Chamberlain

J Cell Sci· September 2018

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Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons.
Louise Ritchie, Rothwell Tate, Luke H Chamberlain, Graham Robertson, Michele Zagnoni

Neuropharmacology· June 2018

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Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy.
Lauren E Jamieson, Jennifer Greaves, Jayde A McLellan, Kevin R Munro, Nicholas C O Tomkinson, Luke H Chamberlain

Spectrochim Acta A Mol Biomol Spectrosc· May 2018

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The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells.
Christine Salaun, Louise Ritchie, Jennifer Greaves, Trevor J Bushell, Luke H Chamberlain

Mol Cell Neurosci· December 2017

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Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 -acyltransferase.
Kimon Lemonidis, Ruth MacLeod, George S Baillie, Luke H Chamberlain

J Biol Chem· October 2017

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Substrate selectivity in the zDHHC family of -acyltransferases.
Kimon Lemonidis, Christine Salaun, Marianna Kouskou, Cinta Diez-Ardanuy, Luke H Chamberlain

Biochem Soc Trans· June 2017

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Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.
Jennifer Greaves, Kevin R Munro, Stuart C Davidson, Matthieu Riviere, Justyna Wojno, Luke H Chamberlain

Proc Natl Acad Sci U S A· February 2017

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A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis.
Cinta Diez-Ardanuy, Jennifer Greaves, Kevin R Munro, Nicholas C O Tomkinson, Luke H Chamberlain

Sci Rep· January 2017

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Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels.
Julia Illison, Lijun Tian, Heather McClafferty, Martin Werno, Luke H Chamberlain

Diabetes· December 2016

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