Publications by authors named "Luke Wiseman"

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Improving Proteostasis of Trafficking-Deficient GABA Receptor Variants by Activating IRE1.
Xu Fu, Ya-Juan Wang, KyungA Lee, Lucie Y Ahn, Xi Chen, R Luke Wiseman

ACS Chem Neurosci· December 2025

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Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells.
Prerona Bora, Mashiat Zaman, Samantha Oviedo, Sergei Kutseikin, Nicole Madrazo, R Luke Wiseman

Proc Natl Acad Sci U S A· December 2025

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Intra-tumoral hypoxia promotes CD8 T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
Coral Del Mar Alicea Pauneto, Brian P Riesenberg, Evelyn J Gandy, Andrew S Kennedy, Genevieve T Clutton, R Luke Wiseman

Immunity· October 2025

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Pharmacological targeting of RIG-I can selectively activate the integrated stress response.
Caroline A Cuoco, Wen Ren, Kelsey R Baron, Sakina Gologo, Valerie Perea, R Luke Wiseman

Sci Adv· October 2025

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Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity.
Chavin Buasakdi, Caroline R Stanton, Prerona Bora, Priyadarshini Chatterjee, Michael J Bollong, R Luke Wiseman

ACS Chem Biol· August 2025

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AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte Loss.
Metin Aksu, Kevin Kaschke, Joseph R Podojil, MingYi Chiang, Ian Steckler, R Luke Wiseman

Glia· June 2025

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Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B.
Thierry Touvier, Francesca A Veneri, Anke Claessens, Cinzia Ferri, Rosa Mastrangelo, R Luke Wiseman

Brain· June 2025

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Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells.
Prerona Bora, Mashiat Zaman, Samantha Oviedo, Sergei Kutseikin, Nicole Madrazo, R Luke Wiseman

bioRxiv· June 2025

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Dysregulation of Retinal and Photoreceptor Structural Integrity Genes in ATF6 Retinal Organoids.
Allyssa Bradley, Masako Le, Soyeon Park, Heike Kroeger, R Luke Wiseman

Adv Exp Med Biol· May 2025

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Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure.
Jie Sun, Kyunga Lee, Sergei Kutseikin, Adrian Guerrero, Bibiana Rius, R Luke Wiseman

ACS Chem Biol· May 2025

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Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal.
Caroline Stanton, Woojin Choi, R Luke Wiseman, Michael J Bollong

bioRxiv· May 2025

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Author Correction: DELE1 oligomerization promotes integrated stress response activation.
Jie Yang, Kelsey R Baron, Daniel E Pride, Anette Schneemann, Xiaoyan Guo, R Luke Wiseman

Nat Struct Mol Biol· April 2025

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Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity.
Gabriel M Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin, Gabrielle Cruz, R Luke Wiseman

bioRxiv· April 2025

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Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation.
Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, R Luke Wiseman

Elife· February 2025

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Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation.
Jessica D Rosarda, Caroline R Stanton, Emily B Chen, Michael J Bollong, R Luke Wiseman

Isr J Chem· December 2024

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Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation.
Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, R Luke Wiseman

bioRxiv· November 2024

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The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome.
Caroline Stanton, Chavin Buasakdi, Jie Sun, Ian Levitan, Prerona Bora, R Luke Wiseman

Cell Rep· September 2024

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Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis.
Gabriel M Kline, Nicole Madrazo, Christian M Cole, Meera Pannikkat, Michael J Bollong, R Luke Wiseman

RSC Chem Biol· August 2024

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Stability of Epinephrine, Norepinephrine, and Phenylephrine for Intravenous Infusions Stored in Three Commercial Plastic Syringe Brands.
Victor M Neira, Ahmed AlFaraj, Luke Wiseman, Rince John, Pantelis Andreou

Anesthesiology· May 2024

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Mapping stress-responsive signaling pathways induced by mitochondrial proteostasis perturbations.
Nicole Madrazo, Zinia Khattar, Evan T Powers, Jessica D Rosarda, R Luke Wiseman

Mol Biol Cell· May 2024

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ATF6 protects against protein misfolding during cardiac hypertrophy.
Christoph Hofmann, Marjan Aghajani, Cecily D Alcock, Erik A Blackwood, Clara Sandmann, R Luke Wiseman

J Mol Cell Cardiol· April 2024

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The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome.
Caroline Stanton, Chavin Buasakdi, Jie Sun, Ian Levitan, Prerona Bora, R Luke Wiseman

bioRxiv· April 2024

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Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly.
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, R Luke Wiseman

ACS Chem Biol· February 2024

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Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B.
Thierry Touvier, Francesca A Veneri, Anke Claessens, Cinzia Ferri, Rosa Mastrangelo, R Luke Wiseman

bioRxiv· February 2024

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Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations.
Nicole Madrazo, Zinia Khattar, Evan T Powers, Jessica D Rosarda, R Luke Wiseman

bioRxiv· February 2024

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