Publications by authors named "Lynnetta Watts"

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Corrigendum to "Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial" [Journal of Clinical Lipidology, Volume 17, Issue 3, May-June 2023, Pages 342-355].
Joseph L Witztum, Daniel Gaudet, Marcello Arca, Alan Jones, Handrean Soran, Lynnetta Watts

J Clin Lipidol· October 2023

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Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial.
Joseph L Witztum, Daniel Gaudet, Marcello Arca, Alan Jones, Handrean Soran, Lynnetta Watts

J Clin Lipidol· June 2023

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Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study: Volanesorsen in FPLD; The BROADEN Study.
Elif A Oral, Abhimanyu Garg, Joseph Tami, Eric A Huang, Louis St L O'Dea, Lynnetta Watts

J Clin Lipidol· January 2023

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Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.
Rohit Loomba, Erin Morgan, Lynnetta Watts, Shuting Xia, Lisa A Hannan

Lancet Gastroenterol Hepatol· September 2020

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Treatment with Volanesorsen, a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide Targeting mRNA, Does Not Affect the QTc Interval in Healthy Volunteers.
Lynnetta M Watts, Ewa Karwatowska-Prokopczuk, Eunju Hurh, Veronica J Alexander, Kristin Balogh

Nucleic Acid Ther· August 2020

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Antisense Inhibition of Glucagon Receptor by IONIS-GCGR Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy.
Erin S Morgan, Li-Jung Tai, Nguyen C Pham, Julia K Overman, Lynnetta M Watts

Diabetes Care· April 2019

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Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1B Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes.
Andres Digenio, Nguyen C Pham, Lynnetta M Watts, Erin S Morgan, Shiangtung W Jung

Diabetes Care· April 2018

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Population pharmacokinetics and pharmacodynamics of IONIS-GCGR, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model.
Kenneth T Luu, Erin S Morgan, Sanjay Bhanot, Richard Geary, Anne Smith, Lynnetta Watts

J Pharmacokinet Pharmacodyn· June 2017

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Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.
Xing Xian Yu, Lynnetta M Watts, Vara Prasad Manchem, Kaushik Chakravarty, Brett P Monia

PLoS One· February 2014

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Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.
Michael M Swarbrick, Peter J Havel, Arthur A Levin, Andrew A Bremer, Kimber L Stanhope, Lynnetta M Watts

Endocrinology· April 2009

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Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice.
Xing Xian Yu, Susan F Murray, Lynnetta Watts, Sheri L Booten, Justin Tokorcheck

Am J Physiol Endocrinol Metab· August 2008

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Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice.
Sanjay K Pandey, Xing Xian Yu, Lynnetta M Watts, M Dodson Michael, Kyle W Sloop

J Biol Chem· May 2007

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.
Christine Esau, Scott Davis, Susan F Murray, Xing Xian Yu, Sanjay K Pandey, Lynnetta Watts

Cell Metab· February 2006

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Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice.
Yin Liang, Melville C Osborne, Brett P Monia, Sanjay Bhanot, Lynnetta M Watts

Metabolism· July 2005

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Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.
Lynnetta M Watts, Vara Prasad Manchem, Thomas A Leedom, Amber L Rivard, Robert A McKay

Diabetes· June 2005

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.
Kyle W Sloop, Julia Xiao-Chun Cao, Angela M Siesky, Hong Yan Zhang, Diane M Bodenmiller, Lynnetta M Watts

J Clin Invest· June 2004

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