Publications by authors named "Madlen B Labib"

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Synthesis and in silico studies of novel thiophene-celecoxib hybrid with excellent cardiotoxicity and nephrotoxicity safety profiles.
Eman K A Abdelall, Phoebe F Lamie, Madlen B Labib, Mahmoud El-Daly, Aya Mishrif

Eur J Med Chem· January 2026

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Synthesis of new selective agents with dual anti-inflammatory and SARS-CoV-2 M inhibitory activity: Antipyrine-celecoxib hybrid analogues; COX-2, COVID-19 cytokine storm and replication inhibitory activities.
Eman K A Abdelall, Heba A H Elshemy, Madlen B Labib, John N Philoppes, Fares E M Ali

Bioorg Chem· June 2025

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Design, synthesis of novel chromene-based scaffolds targeting hepatocellular carcinoma: Cell cycle arrest, cytotoxic effect against resistant cancer cells, apoptosis induction, and c-Src inhibition.
Eman K A Abdelall, Heba A H Elshemy, Madlen B Labib, Fatma E A Mohamed

Drug Dev Res· February 2024

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Novel pyrazole-based COX-2 inhibitors as potential anticancer agents: Design, synthesis, cytotoxic effect against resistant cancer cells, cell cycle arrest, apoptosis induction and dual EGFR/Topo-1 inhibition.
Peter A Halim, Souty M Z Sharkawi, Madlen B Labib

Bioorg Chem· February 2023

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Characterization of novel heterocyclic compounds based on 4-aryl-4H-chromene scaffold as anticancer agents: Design, synthesis, antiprofilerative activity against resistant cancer cells, dual β-tubulin/c-Src inhibition, cell cycle arrest and apoptosis induction.
Eman K A Abdelall, Heba A H Elshemy, Madlen B Labib, Fatma E A Mohamed

Bioorg Chem· March 2022

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Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies.
Khaled R A Abdellatif, Eman K A Abdelall, Madlen B Labib, Wael A A Fadaly, Taha H Zidan

Bioorg Chem· December 2020

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Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE, TNF-α, IL-6 and histopathological study.
Madlen B Labib, Ahmed M Fayez, El-Shaymaa El-Nahass, M Awadallah, Peter A Halim

Bioorg Chem· November 2020

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New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies.
Khaled R A Abdellatif, Eman K A Abdelall, Phoebe F Lamie, Madlen B Labib, El-Shaymaa El-Nahaas

Bioorg Chem· January 2020

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Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.
Khaled R A Abdellatif, Eman K A Abdelall, Madlen B Labib, Wael A A Fadaly, Taha H Zidan

Bioorg Chem· September 2019

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Design, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2Inhibitors.
Mohammed K AbdElhameid, Madlen B Labib, Ahmed T Negmeldin, Muhammad Al-Shorbagy, Manal R Mohammed

J Enzyme Inhib Med Chem· December 2018

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Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study.
Madlen B Labib, Souty M Z Sharkawi, Mahmoud El-Daly

Bioorg Chem· October 2018

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Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
Mohamed A Abdelgawad, Madlen B Labib, Waleed A M Ali, Gehan Kamel, Amany A Azouz

Bioorg Chem· August 2018

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Azole-hydrazone derivatives: Design, synthesis, in vitro biological evaluation, dual EGFR/HER2 inhibitory activity, cell cycle analysis and molecular docking study as anticancer agents.
Madlen B Labib, John N Philoppes, Phoebe F Lamie, Esam R Ahmed

Bioorg Chem· February 2018

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Pyrazole-hydrazone derivatives as anti-inflammatory agents: Design, synthesis, biological evaluation, COX-1,2/5-LOX inhibition and docking study.
Mohamed A Abdelgawad, Madlen B Labib, Mahmoud Abdel-Latif

Bioorg Chem· October 2017

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Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX-2 Inhibitors.
Khaled R A Abdellatif, Mohamed A Abdelgawad, Madlen B Labib, Taha H Zidan

Arch Pharm (Weinheim)· August 2017

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Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.
Khaled R A Abdellatif, Mohamed A Abdelgawad, Madlen B Labib, Taha H Zidan

Bioorg Med Chem Lett· December 2015

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Synthesis of some novel thieno[3,2-d]pyrimidines as potential cytotoxic small molecules against breast cancer.
Manal Kandeel, Mohammed Kamal Abdelhameid, Kamal Eman, Madlen Berty Labib

Chem Pharm Bull (Tokyo)· December 2013

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