Publications by authors named "Peter A Halim"

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Indole-imidazolone derivatives as dual Mcl-1/COX-2 inhibitors: Design-oriented synthesis, molecular docking, and dynamics studies with potential anticancer and anti-inflammatory activities.
Phoebe F Lamie, Peter A Halim, Ahmed M Sayed, Nesma M Kahk, Marwa M Abdelhakeem

Bioorg Chem· October 2025

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Design, synthesis and biological evaluation of novel pyrazoline derivatives as dual EGFR/VEGFR-2 inhibitors for targeted cancer therapy.
Michael M Sawiris, Omneya M Khalil, Peter A Halim, Marwa S A Hassan

Bioorg Chem· October 2025

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From Lab to Target: Pyrazole, Pyrazoline and Fused Pyrazole Derivatives as Receptor Tyrosine Kinase Inhibitors in Cancer Therapy.
Michael M Sawiris, Omneya M Khalil, Peter A Halim, Marwa S A Hassan

Arch Pharm (Weinheim)· August 2025

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Advances in structural identification of some thieno[2,3-d]pyrimidine scaffolds as antitumor molecules: Synthetic approaches and control programmed cancer cell death potential.
Aml E-S Mghwary, Rasha A Hassan, Peter A Halim, Mohammed K Abdelhameid

Bioorg Chem· January 2025

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Design, synthesis, antineoplastic activity of new pyrazolo[3,4-d]pyrimidine derivatives as dual CDK2/GSK3β kinase inhibitors; molecular docking study, and ADME prediction.
Mohamed T M Nemr, Ahmed Elshewy, Mohammed L Ibrahim, Ahmed M El Kerdawy, Peter A Halim

Bioorg Chem· September 2024

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Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3-d]pyrimidine derivatives as EGFR inhibitors.
Menna Tallah M Sayed, Peter A Halim, Afaf K El-Ansary, Rasha A Hassan

Drug Dev Res· September 2023

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Novel pyrazole-based COX-2 inhibitors as potential anticancer agents: Design, synthesis, cytotoxic effect against resistant cancer cells, cell cycle arrest, apoptosis induction and dual EGFR/Topo-1 inhibition.
Peter A Halim, Souty M Z Sharkawi, Madlen B Labib

Bioorg Chem· February 2023

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Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer.
Peter A Halim, Rasha A Hassan, Khaled O Mohamed, Soha O Hassanin, Mona G Khalil

J Enzyme Inhib Med Chem· December 2022

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Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 Inhibitors and Potential Anti-Inflammatory Agents: Evaluation of PGE2, TNF-α, IL-6 and Histopathological Study.
Peter Amir Halim, Hala Bakr El-Nassan, Yara Sayed El-Dash

Med Chem· March 2022

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Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity.
Peter A Halim, Hanan H Georgey, Mina Y George, Ahmed M El Kerdawy, Mona F Said

Bioorg Chem· October 2021

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Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE, TNF-α, IL-6 and histopathological study.
Madlen B Labib, Ahmed M Fayez, El-Shaymaa El-Nahass, M Awadallah, Peter A Halim

Bioorg Chem· November 2020

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Uses of cyclohexane-1,3-dione for the synthesis of 1,2,4-triazine derivatives as anti-proliferative agents and tyrosine kinases inhibitors.
Nadia Y Megally Abdo, Rafat Milad Mohareb, Peter A Halim

Bioorg Chem· April 2020

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Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estrone.
Rafat M Mohareb, Eman M Samir, Peter A Halim

Bioorg Chem· March 2019

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