Publications by authors named "Malcolm Lyon"

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Ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for the structural analysis of N-unsubstituted heparin/heparan sulfate.
Jia Yan Du, Lan Rong Chen, Su Liu, Jiang Hui Lin, Qun Tao Liang, Malcolm Lyon

J Chromatogr B Analyt Technol Biomed Life Sci· August 2016

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Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies.
Zheng Wei, Jon Andrew Deakin, Bärbel Sabine Blaum, Dušan Uhrín, John Thomas Gallagher, Malcolm Lyon

Glycoconj J· December 2011

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Interaction of human β-defensin 2 (HBD2) with glycosaminoglycans.
Emily S Seo, Bärbel S Blaum, Thomas Vargues, Martin De Cecco, Jon A Deakin, Malcolm Lyon

Biochemistry· December 2010

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Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan.
Stéphane Sarrazin, Malcolm Lyon, Jon A Deakin, Marco Guerrini, Philippe Lassalle

Glycobiology· November 2010

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Quantitative and qualitative alterations of heparan sulfate in fibrogenic liver diseases and hepatocellular cancer.
Péter Tátrai, Krisztina Egedi, Aron Somorácz, Toin H van Kuppevelt, Gerdy Ten Dam, Malcolm Lyon

J Histochem Cytochem· May 2010

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Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.
Bärbel S Blaum, Jon A Deakin, Conny M Johansson, Andrew P Herbert, Paul N Barlow, Malcolm Lyon

J Am Chem Soc· May 2010

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Residual dipolar coupling investigation of a heparin tetrasaccharide confirms the limited effect of flexibility of the iduronic acid on the molecular shape of heparin.
Lan Jin, Milos Hricovíni, Jon A Deakin, Malcolm Lyon, Dusan Uhrín

Glycobiology· November 2009

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The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns.
Jon A Deakin, Bärbel S Blaum, John T Gallagher, Dusan Uhrín, Malcolm Lyon

J Biol Chem· March 2009

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Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration.
Aneta J Pockert, Stephen M Richardson, Christine L Le Maitre, Malcolm Lyon, Jonathan A Deakin

Arthritis Rheum· February 2009

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A new map of glycosaminoglycan and C3b binding sites on factor H.
Christoph Q Schmidt, Andrew P Herbert, David Kavanagh, Carina Gandy, Christopher J Fenton, Malcolm Lyon

J Immunol· August 2008

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A simplified and sensitive fluorescent method for disaccharide analysis of both heparan sulfate and chondroitin/dermatan sulfates from biological samples.
Jon A Deakin, Malcolm Lyon

Glycobiology· June 2008

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Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density.
Krista R Catlow, Jon A Deakin, Zheng Wei, Maryse Delehedde, David G Fernig, Malcolm Lyon

J Biol Chem· February 2008

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Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation.
Eun-Ang Raiber, James A Wilkinson, Fabrizio Manetti, Maurizio Botta, Jon Deakin, Malcolm Lyon

Bioorg Med Chem Lett· November 2007

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The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue.
Christophe Vanpouille, Audrey Deligny, Maryse Delehedde, Agnès Denys, Aurélie Melchior, Malcolm Lyon

J Biol Chem· August 2007

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DMT-MM mediated functionalisation of the non-reducing end of glycosaminoglycans.
Emiliano Gemma, Alison N Hulme, Astrid Jahnke, Lan Jin, Malcolm Lyon

Chem Commun (Camb)· July 2007

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Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
Andrew P Herbert, Jon A Deakin, Christoph Q Schmidt, Bärbel S Blaum, Claire Egan, Malcolm Lyon

J Biol Chem· June 2007

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An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity.
Ozen Ozensoy, Feray Kockar, Oktay Arslan, Semra Isik, Claudiu T Supuran, Malcolm Lyon

Clin Biochem· August 2006

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Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure.
Andrew P Herbert, Dusan Uhrín, Malcolm Lyon, Michael K Pangburn, Paul N Barlow

J Biol Chem· June 2006

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HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.
Kenji Uchimura, Megumi Morimoto-Tomita, Annette Bistrup, Jessica Li, Malcolm Lyon

BMC Biochem· January 2006

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Conformation of glycosaminoglycans by ion mobility mass spectrometry and molecular modelling.
Lan Jin, Perdita E Barran, Jon A Deakin, Malcolm Lyon, Dusan Uhrín

Phys Chem Chem Phys· October 2005

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Distinct substrate specificities of bacterial heparinases against N-unsubstituted glucosamine residues in heparan sulfate.
Zheng Wei, Malcolm Lyon, John T Gallagher

J Biol Chem· April 2005

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The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides.
Malcolm Lyon, Jon A Deakin, Daniel Lietha, Ermanno Gherardi, John T Gallagher

J Biol Chem· October 2004

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A new model for the domain structure of heparan sulfate based on the novel specificity of K5 lyase.
Kevin J Murphy, Catherine L R Merry, Malcolm Lyon, James E Thompson, Ian S Roberts

J Biol Chem· June 2004

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Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates.
Fiona H Blackhall, Catherine L R Merry, Malcolm Lyon, Gordon C Jayson, Judah Folkman

Biochem J· October 2003

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Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts.
Maryse Delehedde, Malcolm Lyon, John T Gallagher, Philip S Rudland, David G Fernig

Biochem J· August 2002

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