Publications by authors named "Man Pan"

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Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains.
Zebin Tong, Xiangwei Wu, Hongyi Cai, Shidian Wu, Tianyi Zhang, Man Pan

Nat Chem Biol· August 2025

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Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168.
Huasong Ai, Zebin Tong, Zhiheng Deng, Qiang Shi, Shixian Tao, Man Pan

Nat Chem Biol· May 2025

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Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs.
Jibin Cui, Qingyun Zheng, Yicheng Weng, Xiaoguo Zhai, Zhen Su, Man Pan

Angew Chem Int Ed Engl· May 2025

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Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination.
Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Man Pan

Nat Commun· May 2025

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Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16.
Huasong Ai, Zaozhen He, Zhiheng Deng, Guo-Chao Chu, Qiang Shi, Man Pan

Nat Struct Mol Biol· November 2024

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Chemical Synthesis of Human Proteoforms and Application in Biomedicine.
Huasong Ai, Man Pan, Lei Liu

ACS Cent Sci· August 2024

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Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
Zebin Tong, Huasong Ai, Ziyu Xu, Kezhang He, Guo-Chao Chu, Man Pan

Nat Struct Mol Biol· February 2024

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Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1.
Xiangwei Wu, Yunxiang Du, Lu-Jun Liang, Ruichao Ding, Tianyi Zhang, Man Pan

Nat Commun· February 2024

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Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.
Zhiheng Deng, Huasong Ai, Maoshen Sun, Zebin Tong, Yunxiang Du, Man Pan

Mol Cell· September 2023

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A bifunctional molecule-assisted synthesis of mimics for use in probing the ubiquitination system.
Qingyun Zheng, Tian Wang, Junxiong Mao, Guochao Chu, Lujun Liang, Man Pan

Nat Protoc· February 2023

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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Wenguang G Liang, Juwina Wijaya, Hui Wei, Alex J Noble, Jordan M Mancl, Man Pan

Nat Commun· April 2022

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Structural insights into Ubr1-mediated N-degron polyubiquitination.
Man Pan, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao

Nature· December 2021

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K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
Yuanyuan Yu, Qingyun Zheng, Satchal K Erramilli, Man Pan, Seongjin Park

Nat Chem Biol· August 2021

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Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Man Pan, Yuanyuan Yu, Huasong Ai, Qingyun Zheng, Yuan Xie

Nat Struct Mol Biol· July 2021

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Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.
Man Pan, Qingyun Zheng, Yuanyuan Yu, Huasong Ai, Yuan Xie

Nat Commun· January 2021

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Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Demeng Sun, Sanling Liu, Siyu Li, Mengge Zhang, Fan Yang, Pan Shi, Man Pan

Elife· September 2020

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An E1-Catalyzed Chemoenzymatic Strategy to Isopeptide-N-Ethylated Deubiquitylase-Resistant Ubiquitin Probes.
Qingyun Zheng, Tian Wang, Guo-Chao Chu, Chong Zuo, Rui Zhao, Man Pan

Angew Chem Int Ed Engl· August 2020

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Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.
Jingxian Li, Yuan Xie, Shaleeka Cornelius, Xian Jiang, Richard Sando, Man Pan

Nat Commun· May 2020

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Insights into the Design of p97-targeting Small Molecules from Structural Studies on p97 Functional Mechanism.
Xin Sui, Man Pan, Yi-Ming Li

Curr Med Chem· February 2020

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Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains.
Man Pan, Qingyun Zheng, Shan Ding, Lujia Zhang, Qian Qu

Angew Chem Int Ed Engl· February 2019

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Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones.
Guo-Chao Chu, Man Pan, Jiabin Li, Sanling Liu, Chong Zuo

J Am Chem Soc· February 2019

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A Highly Efficient Synthesis of Polyubiquitin Chains.
Qian Qu, Man Pan, Shuai Gao, Qing-Yun Zheng, Yuan-Yuan Yu

Adv Sci (Weinh)· July 2018

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Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect.
Demeng Sun, You Yu, Xiaobin Xue, Man Pan, Ming Wen

Cell Discov· June 2018

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Structural basis of ubiquitin modification by the Legionella effector SdeA.
Yanan Dong, Yajuan Mu, Yongchao Xie, Yupeng Zhang, Youyou Han, Man Pan

Nature· May 2018

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Chemical Synthesis of Natural Polyubiquitin Chains through Auxiliary-Mediated Ligation of an Expressed Ubiquitin Isomer.
Ling Xu, Jian-Feng Huang, Chen-Chen Chen, Qian Qu, Jing Shi, Man Pan

Org Lett· January 2018

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