Publications by authors named "Man-Cheng Tang"

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Discovery and Biosynthesis of Cytotoxic Myroverols: A Phenalenone Scaffold Constructed by a Fungal Highly Reducing Polyketide Synthase and a Cytochrome P450.
Wei Lin, Yang-Le Gao, Kai Sang, Song-Tao Wang, Jian-Bin Xiao, Man-Cheng Tang

Org Lett· December 2025

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Biosynthesis of Trichobisabolins Involves a UbiA-Type Terpene Cyclase for -Zingiberenol Generation and a Single Cytochrome P450 Catalyzing the γ-Butenolide Formation from an Isoprene Unit.
Cheng Shen, Rui-Ting Guo, Lin Chen, Ya-Qian Li, Jie Chen, Man-Cheng Tang

Org Lett· November 2025

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Serine Hydrolase-Catalyzed Polyol Lipids are Necessary for Rodlet Layer Formation on the Cell Wall of Entomopathogenic Fungi.
Dekun Kong, Qian He, Dong-Mei Lin, Huaran Zhang, Lin Chen, Man-Cheng Tang

J Am Chem Soc· February 2025

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Genome Mining of a Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase Hybrid Megasynthetase Pathway to Synthesize a Phytotoxic -Acyl Amino Acid.
Lin Chen, Xin Wang, Yi Zou, Man-Cheng Tang

Org Lett· May 2024

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α-Pyrone Derivatives from Discovered by Genome Mining.
Jia-Yu Dong, Man-Cheng Tang, Ling Liu

J Nat Prod· November 2023

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Flavoprotein StnP2 Catalyzes the β-Carboline Formation during the Streptonigrin Biosynthesis.
Xiaozheng Wang, Dekun Kong, Tingting Huang, Fei Xu, Man-Cheng Tang

ACS Chem Biol· December 2022

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Discovery and biosynthesis of macrophasetins from the plant pathogen fungus .
Cui Yu, Lin Chen, Yang Le Gao, Jia Liu, Pei Lin Li, Man Cheng Tang

Front Microbiol· November 2022

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Genome Mining Discovery of a New Benzazepine Alkaloid Pseudofisnin A from the Marine Fungus F27-1.
Xiao-Xin Xue, Lin Chen, Man-Cheng Tang

Antibiotics (Basel)· October 2022

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Combinatorial Biosynthesis of Terpenoids through Mixing-and-Matching Sesquiterpene Cyclase and Cytochrome P450 Pairs.
Man-Cheng Tang, Cheng Shen, Zixin Deng, Masao Ohashi, Yi Tang

Org Lett· July 2022

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Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics.
Wan-Hong Wen, Yue Zhang, Ying-Ying Zhang, Qian Yu, Chu-Chu Jiang, Man-Cheng Tang, Gong-Li Tang

Nat Commun· December 2021

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TerC Is a Multifunctional and Promiscuous Flavoprotein Monooxygenase That Catalyzes Bimodal Oxidative Transformations.
Xian Shu, Guangzheng Wei, Yuben Qiao, Kexin Zhang, Jun Zhang, Man-Cheng Tang

Org Lett· November 2021

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Genome-Directed Discovery of Tetrahydroisoquinolines from Deep-Sea Derived SCSIO 3406.
Jiafan Yang, Yongxiang Song, Man-Cheng Tang, Mingzhe Li, Junwei Deng

J Org Chem· August 2021

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Biosynthesis of Cyclophane-Containing Hirsutellone Family of Fungal Natural Products.
Masao Ohashi, Thomas B Kakule, Man-Cheng Tang, Cooper S Jamieson, Mengting Liu, Yi Tang

J Am Chem Soc· April 2021

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An enzymatic Alder-ene reaction.
Masao Ohashi, Cooper S Jamieson, Yujuan Cai, Dan Tan, Daiki Kanayama, Man-Cheng Tang, Yi Tang

Nature· October 2020

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Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products.
Ling Liu, Man-Cheng Tang, Yi Tang

J Am Chem Soc· December 2019

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Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi.
Man-Cheng Tang, Curt R Fischer, Jason V Chari, Dan Tan, Sundari Suresh, Yi Tang

J Am Chem Soc· May 2019

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Genome-Mined Diels-Alderase Catalyzes Formation of the cis-Octahydrodecalins of Varicidin A and B.
Dan Tan, Cooper S Jamieson, Masao Ohashi, Man-Cheng Tang, K N Houk, Yi Tang

J Am Chem Soc· January 2019

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Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in IBT 5891.
Man-Cheng Tang, Yi Zou, Danielle Yee, Yi Tang

AIChE J· December 2018

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Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis.
Yue Zhang, Wan-Hong Wen, Jin-Yue Pu, Man-Cheng Tang, Liwen Zhang, Gong-Li Tang

Proc Natl Acad Sci U S A· October 2018

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Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids.
Li Li, Man-Cheng Tang, Shoubin Tang, Shushan Gao, Sameh Soliman, Yi Tang

J Am Chem Soc· February 2018

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Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae.
John M Billingsley, Anthony B DeNicola, Joyann S Barber, Man-Cheng Tang, Joe Horecka, Yi Tang

Metab Eng· November 2017

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Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products.
Man-Cheng Tang, Xiaoqing Cui, Xueqian He, Zhuang Ding, Tianjiao Zhu, Yi Tang

Org Lett· October 2017

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SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis.
Masao Ohashi, Fang Liu, Yang Hai, Mengbin Chen, Man-Cheng Tang, Yi Tang

Nature· September 2017

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Biosynthesis of Complex Indole Alkaloids: Elucidation of the Concise Pathway of Okaramines.
Chen-Yu Lai, I-Wen Lo, Ranuka T Hewage, Yi-Chen Chen, Chien-Ting Chen, Man-Cheng Tang

Angew Chem Int Ed Engl· August 2017

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Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain.
Leibniz Hang, Man-Cheng Tang, Colin J B Harvey, Claire G Page, Jian Li, Yi Tang

Angew Chem Int Ed Engl· August 2017

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