Publications by authors named "Manfred Marschall"

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The phospho-dynamics of cytomegalovirus capsid interaction, with its protein kinase and nuclear egress complex, provide an antiviral targeting concept.
Julia Tillmanns, Christina Wangen, Pia Geiger, Sigrun Häge, Tihana Lenac Roviš, Manfred Marschall

Antiviral Res· December 2025

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New Assay Systems to Characterize the Broad-Spectrum Antiherpesviral and Non-Herpesviral Activity of Cyclin-Dependent Kinase (CDK) 8 Inhibitors.
Debora Obergfäll, Friedrich Hahn, Jintawee Kicuntod, Christina Wangen, Melanie Kögler, Manfred Marschall

Pharmaceuticals (Basel)· October 2025

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Conserved mode of nuclear lamina distortion by primate cytomegaloviruses: importance of the pSer22 motif, viral kinase and / isomerase Pin1 activity.
Kishore Dhotre, Martin Schütz, Sofia von Essen, Lucio Fortelny, Christina Wangen, Manfred Marschall

J Gen Virol· October 2025

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The conserved core nuclear egress complex (NEC) as an antiherpesviral drug target: Pharmacophore-based identification of NEC-specific inhibitors.
Julia Tillmanns, Verena Battisti, Jintawee Kicuntod, Friedrich Hahn, Debora Obergfäll, Manfred Marschall

Antiviral Res· July 2025

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Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti-SARS-CoV-2 Activity.
Christian Gege, Friedrich Hahn, Christina Wangen, Sigrun Häge, Alexandra Herrmann, Manfred Marschall

ChemMedChem· October 2024

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Cyclin-Dependent Kinase 8 Represents a Positive Regulator of Cytomegalovirus Replication and a Novel Host Target for Antiviral Strategies.
Debora Obergfäll, Markus Wild, Mona Sommerer, Malena Barillas Dahm, Jintawee Kicuntod, Manfred Marschall

Pharmaceutics· September 2024

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Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target.
Manfred Marschall, Martin Schütz, Markus Wild, Eileen Socher, Christina Wangen

Cells· August 2024

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Establishment of a Luciferase-Based Reporter System to Study Aspects of Human Cytomegalovirus Infection, Replication Characteristics, and Antiviral Drug Efficacy.
Julia Tillmanns, Jintawee Kicuntod, Antonia Ehring, Endrit Elbasani, Eva Maria Borst, Manfred Marschall

Pathogens· July 2024

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Human Cytomegalovirus Dysregulates Cellular Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases and Sonic Hedgehog Pathway Proteins in Neural Astrocyte and Placental Models.
Ece Egilmezer, Stuart T Hamilton, Glen Lauw, Jasmine Follett, Eric Sonntag, Manfred Marschall

Viruses· June 2024

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Human cytomegalovirus (CMV) dysregulates neurodevelopmental pathways in cerebral organoids.
Ece Egilmezer, Stuart T Hamilton, Charles S P Foster, Manfred Marschall, William D Rawlinson

Commun Biol· March 2024

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'Getting Better'-Is It a Feasible Strategy of Broad Pan-Antiherpesviral Drug Targeting by Using the Nuclear Egress-Directed Mechanism?
Julia Tillmanns, Jintawee Kicuntod, Josephine Lösing, Manfred Marschall

Int J Mol Sci· February 2024

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Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels.
Christina Wangen, Andrea Raithel, Julia Tillmanns, Christian Gege, Alexandra Herrmann, Manfred Marschall

Antiviral Res· January 2024

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An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity.
DongHoon Yu, Sabrina Wagner, Martin Schütz, Yeejin Jeon, Mooyoung Seo, Manfred Marschall

Pharmaceutics· January 2024

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The Interactive Complex between Cytomegalovirus Kinase vCDK/pUL97 and Host Factors CDK7-Cyclin H Determines Individual Patterns of Transcription in Infected Cells.
Martin Schütz, Arne Cordsmeier, Christina Wangen, Anselm H C Horn, Emanuel Wyler, Manfred Marschall

Int J Mol Sci· December 2023

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Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers.
Markus Wild, Dubravka Karner, Jan Eickhoff, Sabrina Wagner, Jintawee Kicuntod, Manfred Marschall

Pharmaceutics· November 2023

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Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Manfred Marschall

Virus Res· October 2023

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Autofluorescent Artemisinin-Benzimidazole Hybrids via Organo-Click Reaction: Study of Antiviral Properties and Mode of Action in Living Cells.
Lars Herrmann, Friedrich Hahn, Benedikt W Grau, Markus Wild, Aischa Niesar, Manfred Marschall

Chemistry· August 2023

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An antiviral targeting strategy based on the inducible interference with cytomegalovirus nuclear egress complex.
Jintawee Kicuntod, Sigrun Häge, Josephine Lösing, Serli Kopar, Yves A Muller, Manfred Marschall

Antiviral Res· April 2023

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Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target.
Julia Tillmanns, Sigrun Häge, Eva Maria Borst, Julia Wardin, Jan Eickhoff, Manfred Marschall

Cells· April 2023

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'Shared-Hook' and 'Changed-Hook' Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis.
Josephine Lösing, Sigrun Häge, Martin Schütz, Sabrina Wagner, Julia Wardin, Manfred Marschall

Cells· December 2022

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The Trimeric Artesunate Analog TF27, a Broadly Acting Anti-Infective Model Drug, Exerts Pronounced Anti-SARS-CoV-2 Activity Spanning Variants and Host Cell Types.
Friedrich Hahn, Christina Wangen, Sigrun Häge, Lars Herrmann, Alexandra Herrmann, Manfred Marschall

Pharmaceutics· December 2022

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Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H.
Martin Schütz, Regina Müller, Eileen Socher, Christina Wangen, Florian Full, Manfred Marschall

Int J Mol Sci· October 2022

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Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses.
Nadine Krämer, Martin Schütz, Uxía Gestal Mato, Lina Herhaus, Manfred Marschall

Viruses· October 2022

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A Peptide Inhibitor of the Human Cytomegalovirus Core Nuclear Egress Complex.
Sewar Alkhashrom, Jintawee Kicuntod, Katharina Stillger, Tamara Lützenburg, Christian Anzenhofer, Manfred Marschall

Pharmaceuticals (Basel)· August 2022

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'Come together'-The Regulatory Interaction of Herpesviral Nuclear Egress Proteins Comprises Both Essential and Accessory Functions.
Sigrun Häge, Manfred Marschall

Cells· June 2022

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