Publications by authors named "Manuel Medarde"

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Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy.
Myriam González, Younes Ellahioui, Laura Gallego, Alba Vicente-Blázquez, Raquel Álvarez, Manuel Medarde

Bioorg Chem· February 2023

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Methoxy and bromo scans on -(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line.
Myriam González, María Ovejero-Sánchez, Alba Vicente-Blázquez, Manuel Medarde, Rogelio González-Sarmiento

J Enzyme Inhib Med Chem· December 2021

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New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure-activity relationships, and molecular modelling.
Alba Vicente-Blázquez, Myriam González, Manuel Medarde, Faustino Mollinedo, Rafael Peláez

J Enzyme Inhib Med Chem· December 2021

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New diarylsulfonamide inhibitors of Leishmania infantum amastigotes.
Myriam González, Pedro José Alcolea, Raquel Álvarez, Manuel Medarde, Vicente Larraga

Int J Parasitol Drugs Drug Resist· August 2021

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Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy.
Myriam González, María Ovejero-Sánchez, Alba Vicente-Blázquez, Raquel Álvarez, Ana B Herrero, Manuel Medarde

Int J Mol Sci· February 2021

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Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents.
Raquel Álvarez, Laura Aramburu, Consuelo Gajate, Alba Vicente-Blázquez, Faustino Mollinedo, Manuel Medarde

Eur J Med Chem· January 2021

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Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring.
Raquel Álvarez, Laura Aramburu, Consuelo Gajate, Alba Vicente-Blázquez, Faustino Mollinedo, Manuel Medarde

Bioorg Chem· May 2020

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The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors.
Myriam González, Younes Ellahioui, Raquel Álvarez, Laura Gallego-Yerga, Esther Caballero, Manuel Medarde

Molecules· November 2019

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Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target.
Alba Vicente-Blázquez, Myriam González, Raquel Álvarez, Sara Del Mazo, Manuel Medarde

Med Res Rev· May 2019

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Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells.
Raquel Álvarez, Consuelo Gajate, Pilar Puebla, Faustino Mollinedo, Manuel Medarde

Eur J Med Chem· October 2018

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New ligands of the tubulin colchicine site based on X-ray structures.
Raquel Álvarez, Manuel Medarde, Rafael Peláez

Curr Top Med Chem· August 2015

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Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.
Carmen Jiménez, Younes Ellahioui, Raquel Álvarez, Laura Aramburu, Alejandra Riesco, Manuel Medarde

Eur J Med Chem· July 2015

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p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition.
Raquel Álvarez, Vilmarí López, Carmen Mateo, Manuel Medarde, Rafael Peláez

J Org Chem· August 2014

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Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.
Raquel Álvarez, Pilar Puebla, J Fernando Díaz, Ana C Bento, Rósula García-Navas, Manuel Medarde

J Med Chem· April 2013

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New para-para stilbenophanes: synthesis by McMurry coupling, conformational analysis and inhibition of tubulin polymerisation.
Raquel Álvarez, Vilmarí López, Carmen Mateo, Manuel Medarde, Rafael Peláez

Chemistry· March 2011

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Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins.
Concepción Alvarez, Raquel Alvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde

Eur J Med Chem· February 2010

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Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.
Raquel Alvarez, Concepción Alvarez, Faustino Mollinedo, Beatriz G Sierra, Manuel Medarde

Bioorg Med Chem· September 2009

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Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.
Concepción Alvarez, Raquel Alvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde

Bioorg Med Chem· October 2008

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Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.
Concepción Alvarez, Raquel Alvarez, Purificación Corchete, José Luis López, Concepción Pérez-Melero, Manuel Medarde

Bioorg Med Chem· June 2008

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Conformationally restricted macrocyclic analogues of combretastatins.
Carmen Mateo, Raquel Alvarez, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde

Bioorg Med Chem Lett· November 2007

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Synthesis and conformational analysis of macrocyclic dihydroxystilbenes linked between the para-para positions.
Carmen Mateo, Vilmarí López, Manuel Medarde, Rafael Peláez

Chemistry· October 2007

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Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins.
Concepción Alvarez, Raquel Alvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde

Bioorg Med Chem Lett· June 2007

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Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases.
Marta Vallejo, Maria A Castro, Manuel Medarde, Rocio I R Macias, Marta R Romero

Biochem Pharmacol· May 2007

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Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.
Marta Vicens, Manuel Medarde, Rocio I R Macias, Monica G Larena, Antonio Villafaina

Bioorg Med Chem· March 2007

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Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.
Javier Figueroa, Esther Caballero, Pilar Puebla, Fernando Tomé, Manuel Medarde

Molecules· November 2006

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