Publications by authors named "Marc Hummersone"

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Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.
David Cousin, Marc G Hummersone, Tracey D Bradshaw, Jihong Zhang, Christopher J Moody

Medchemcomm· March 2018

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N3-substituted temozolomide analogs overcome methylguanine-DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death.
Jihong Zhang, Marc Hummersone, Charles S Matthews, Malcolm F G Stevens, Tracey D Bradshaw

Oncology· March 2015

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Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.
Angela Rizzo, Sara Iachettini, Pasquale Zizza, Chiara Cingolani, Manuela Porru, Marc Hummersone

J Exp Clin Cancer Res· February 2015

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Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.
Angela Rizzo, Sara Iachettini, Pasquale Zizza, Chiara Cingolani, Manuela Porru, Marc Hummersone

J Exp Clin Cancer Res· October 2014

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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.
Sara Iachettini, Malcolm Fg Stevens, Mark Frigerio, Marc G Hummersone, Ian Hutchinson

J Exp Clin Cancer Res· September 2013

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1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.
Céline Cano, Kappusamy Saravanan, Chris Bailey, Julia Bardos, Nicola J Curtin, Marc G Hummersone

J Med Chem· August 2013

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Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Kurt G Pike, Karine Malagu, Marc G Hummersone, Keith A Menear, Heather M E Duggan

Bioorg Med Chem Lett· March 2013

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Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair.
Jihong Zhang, Malcolm F G Stevens, Marc Hummersone, Srinivasan Madhusudan, Charles A Laughton

Oncology· September 2011

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DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype.
Céline Cano, Olivier R Barbeau, Christine Bailey, Xiao-Ling Cockcroft, Nicola J Curtin, Marc G Hummersone

J Med Chem· December 2010

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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.
Christine M Chresta, Barry R Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Marc Hummersone

Cancer Res· January 2010

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The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.
Karine Malagu, Heather Duggan, Keith Menear, Marc Hummersone, Sylvie Gomez

Bioorg Med Chem Lett· October 2009

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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.
Sarah E Golding, Elizabeth Rosenberg, Nicholas Valerie, Isa Hussaini, Mark Frigerio, Marc Hummersone

Mol Cancer Ther· October 2009

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Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Jonathan J Hollick, Laurent J M Rigoreau, Celine Cano-Soumillac, Xiaoling Cockcroft, Nicola J Curtin, Marc G Hummersone

J Med Chem· April 2007

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Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7.
Soraya Manaviazar, Mark Frigerio, Gurpreet S Bhatia, Marc G Hummersone, Abil E Aliev

Org Lett· September 2006

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Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process.
Karl J Hale, Mark Frigerio, Soraya Manaviazar, Marc G Hummersone, Ian J Fillingham

Org Lett· February 2003

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The chemistry and biology of the bryostatin antitumour macrolides.
Karl J Hale, Marc G Hummersone, Soraya Manaviazar, Mark Frigerio

Nat Prod Rep· August 2002

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