Publications by authors named "Marc Lake"

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Development and validation of an ultra-performance liquid chromatography with tandem mass spectrometry method for determination of soluble repulsive guidance molecule A in human serum and cerebrospinal fluid.
Patrick Schreier, Lili Huang, Emma Fung, Jennifer Mollon, Bernhard Sielaff, Marc R Lake

Bioanalysis· November 2024

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Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells.
Kari Barlan, Gaurang P Bhide, Derek R White, Marc R Lake, Charles Lu

SLAS Discov· January 2024

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Novel method to specifically determine the structures of non-N297 glycans in IgGs.
Gaurang P Bhide, Natalie E Bohrer, Danying Song, Jeanne Cabel, Marc R Lake

Glycobiology· June 2023

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In silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies.
Xin Yu, Merlinda Conyne, Marc R Lake, Karl A Walter, Jing Min

MAbs· April 2022

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An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Sarah Chan, Nicole Belmar, Sun Ho, Bryan Rogers, Marcia Stickler, Marc Lake

Nat Cancer· March 2022

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Empowering therapeutic antibodies with IFN-α for cancer immunotherapy.
Jun Guo, Yu Xiao, Ramesh Iyer, Xin Lu, Marc Lake

PLoS One· April 2020

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A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity.
Shiming Ye, Diane Cohen, Nicole A Belmar, Donghee Choi, Siu Sze Tan, Marc Lake

Cancer Immunol Res· November 2019

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CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
Maria A Argiriadi, Lorenzo Benatuil, Ievgeniia Dubrovska, David A Egan, Lei Gao, Marc Lake

BMC Mol Cell Biol· August 2019

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Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.
Andrew M Petros, Alla Korepanova, Clarissa G Jakob, Wei Qiu, Sanjay C Panchal, Marc Lake

J Med Chem· April 2019

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Fragment-based discovery of a potent NAMPT inhibitor.
Alla Korepanova, Kenton L Longenecker, Steve D Pratt, Sanjay C Panchal, Richard F Clark, Marc Lake

Bioorg Med Chem Lett· February 2018

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Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors.
Henning Stockmann, Viktor Todorovic, Paul L Richardson, Violeta Marin, Victoria Scott, Marc Lake

J Am Chem Soc· November 2017

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Species differences and molecular determinant of TRPA1 cold sensitivity.
Jun Chen, Dawon Kang, Jing Xu, Marc Lake, James O Hogan

Nat Commun· April 2014

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Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design.
Enrico L Digiammarino, John E Harlan, Karl A Walter, Uri S Ladror, Rohinton P Edalji, Marc R Lake

MAbs· March 2012

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Development of ELISA to measure TRPV1 protein in rat tissues.
Ping Han, Alla V Korepanova, Melissa H Vos, Ana Pereda-Lopez, Marc R Lake

J Neurosci Methods· September 2011

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Application of large-scale transient transfection to cell-based functional assays for ion channels and GPCRs.
Jun Chen, Sujatha Gopalakrishnan, Marc R Lake, Bruce R Bianchi, John Locklear

Methods Enzymol· March 2011

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Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.
Alla Korepanova, Ana Pereda-Lopez, Larry R Solomon, Karl A Walter, Marc R Lake

Protein Expr Purif· May 2009

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Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).
Wende Niforatos, Xu-Feng Zhang, Marc R Lake, Karl A Walter, Torben Neelands

Mol Pharmacol· May 2007

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Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Chaohong Sun, Danying Song, Rachel A Davis-Taber, Leo W Barrett, Victoria E Scott, Marc R Lake

Proc Natl Acad Sci U S A· May 2007

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Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists.
Jun Chen, Marc R Lake, Reza S Sabet, Wende Niforatos, Steve D Pratt

J Biomol Screen· February 2007

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Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
Zhonghua Pei, Xiaofeng Li, Kenton Longenecker, Thomas W von Geldern, Paul E Wiedeman, Marc R Lake

J Med Chem· June 2006

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