Publications by authors named "Marc Retter"

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A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humans.
Heinrich E Lob, Nikhil Singh, Kusha Mohammadi, Larisa Ivanova, Beth Crowell, Marc W Retter

JCI Insight· June 2025

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Industry Perspective on First-in-Human and Clinical Pharmacology Strategies to Support Clinical Development of T-Cell Engaging Bispecific Antibodies for Cancer Therapy.
Prathap Nagaraja Shastri, Nirav Shah, Martin Lechmann, Hardik Mody, Marc W Retter

Clin Pharmacol Ther· January 2025

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Translational findings support regimen selection for first-in-human study of ubamatamab (MUC16 × CD3 bispecific antibody) in patients with recurrent ovarian cancer.
Min Zhu, Priyanka Madia, Alison Crawford, Jurriaan Brouwer-Visser, Pamela Krueger, Marc W Retter

Clin Transl Sci· December 2024

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Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates.
Kishor Devalaraja-Narashimha, Cong Huang, Marc Cao, Ya Ping Chen, Anna Borodovsky, Marc W Retter

PLoS One· June 2022

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Translational findings for odronextamab: From preclinical research to a first-in-human study in patients with CD20+ B-cell malignancies.
Min Zhu, Kara Olson, Jessica R Kirshner, Masood Khaksar Toroghi, Hong Yan, Marc W Retter

Clin Transl Sci· April 2022

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A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade.
John O DaSilva, Katie Yang, Oliver Surriga, Thomas Nittoli, Arthur Kunz, Marc W Retter

Mol Cancer Ther· October 2021

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Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning.
Lauric Haber, Kara Olson, Marcus P Kelly, Alison Crawford, David J DiLillo, Marc W Retter

Sci Rep· July 2021

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A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells.
David J DiLillo, Kara Olson, Katja Mohrs, Thomas Craig Meagher, Kevin Bray, Marc W Retter

Blood Adv· March 2021

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Preclinical PET imaging with the novel human antibody Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues.
Marcus P Kelly, Sosina Makonnen, Carlos Hickey, T Cody Arnold, Jason T Giurleo, Marc W Retter

J Immunother Cancer· January 2021

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Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.
Adrianna Latuszek, Yashu Liu, Olav Olsen, Randi Foster, Marc Cao, Marc W Retter

PLoS One· July 2020

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A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer.
Alison Crawford, Lauric Haber, Marcus P Kelly, Kristin Vazzana, Lauren Canova, Marc W Retter

Sci Transl Med· June 2019

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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Marc W Retter

J Pharmacol Exp Ther· April 2015

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Impact of glycation on antibody clearance.
Jane Yang, Ronya Primack, Mike Frohn, Wei Wang, Peng Luan, Marc W Retter

AAPS J· January 2015

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Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy.
Graeme J Moffat, Rhian Davies, Gayle Kwon, Marc W Retter, Gary J Chellman

Reprod Toxicol· September 2014

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Evaluation of matrix microsampling methods for therapeutic drug candidate quantification in discovery-stage rodent pharmacokinetic studies.
Marcus Soto, Roger Pham, Valerie Almon, Mylo Wagner, Ronya Primack, Marc W Retter

Bioanalysis· August 2014

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Placental transfer of a fully human IgG2 monoclonal antibody in the cynomolgus monkey, rat, and rabbit: a comparative assessment from during organogenesis to late gestation.
Graeme J Moffat, Marc W Retter, Gayle Kwon, Mark Loomis, M Benjamin Hock

Birth Defects Res B Dev Reprod Toxicol· April 2014

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Homeostasis of human NK cells is not IL-15 dependent.
Herve Lebrec, Michelle J Horner, Kevin S Gorski, Wayne Tsuji, Dong Xia, Marc Retter

J Immunol· December 2013

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Measurement of in vivo therapeutic mAb concentrations: comparison of conventional serum/plasma collection and analysis to dried blood spot sampling.
Katherine C Matsuda, Colin Hall, Cassandra Baker-Lee, Marcus Soto, George Scott, Marc W Retter

Bioanalysis· August 2013

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Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.
Clapton S Dias, Adam J Shaywitz, Scott M Wasserman, Brian P Smith, Bing Gao, Marc W Retter

J Am Coll Cardiol· November 2012

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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.
Kannan Gunasekaran, Martin Pentony, Min Shen, Logan Garrett, Carla Forte, Marc Retter

J Biol Chem· June 2010

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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Joyce C Y Chan, Derek E Piper, Qiong Cao, Dongming Liu, Chadwick King, Marc W Retter

Proc Natl Acad Sci U S A· June 2009

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Endowing self-binding feature restores the activities of a loss-of-function chimerized anti-GM2 antibody.
Yunfeng Zhao, Michael Russ, Marc Retter, Gary Fanger, Charles Morgan

Cancer Immunol Immunother· February 2007

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Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts.
Marc W Retter, Jeffrey C Johnson, David W Peckham, Jeannette E Bannink, Chaitanya S Bangur

Cancer Res· July 2005

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Identification and characterization of L985P, a CD20 related family member over-expressed in small cell lung carcinoma.
Chaitanya S Bangur, Jeffrey C Johnson, Ann Switzer, Yi-Hong Wang, Beth Hill, Marc W Retter

Int J Oncol· December 2004

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Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.
Djemel Aït-Azzouzene, Patrick Skog, Marc Retter, Valerie Kouskoff, Marc Hertz

Immunol Rev· February 2004

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