Publications by authors named "Marc Therrien"

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RAS signaling gets granular.
Hugo Lavoie, Marc Therrien

Nat Chem Biol· August 2025

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Blocking a key node in cancer signalling unlocks therapeutic potential.
Hugo Lavoie, Marc Therrien

Nature· June 2025

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BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Hugo Lavoie, Ting Jin, Driss Lajoie, Marion Decossas, Patrick Gendron, Marc Therrien

Science· May 2025

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Tao and Rap2l ensure proper Misshapen activation and levels during Drosophila border cell migration.
Gabriela Molinari Roberto, Alison Boutet, Sarah Keil, Emmanuelle Del Guidice, Eloïse Duramé, Marc Therrien

Dev Cell· January 2025

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The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Pierre Maisonneuve, Malha Sahmi, Fanny Bergeron-Labrecque, Xianjie Iris Ma, Juliette Queguiner, Marc Therrien

Nat Struct Mol Biol· July 2024

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The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in larvae.
Julie A Johannessen, Miriam Formica, Aina Louise C Haukeland, Nora Rojahn Bråthen, Amani Al Outa, Marc Therrien

iScience· October 2023

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CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.
Guillaume Serwe, David Kachaner, Jessica Gagnon, Cédric Plutoni, Driss Lajoie, Marc Therrien

Nat Commun· June 2023

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Structural keys unlock RAS-MAPK cellular signalling pathway.
Hugo Lavoie, Marc Therrien

Nature· September 2022

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A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.
Gwenaëlle Gavory, Caroline Baril, Gino Laberge, Gawa Bidla, Surapong Koonpaew, Marc Therrien

PLoS Genet· August 2021

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Functional characterization of a PROTAC directed against BRAF mutant V600E.
Ganna Posternak, Xiaojing Tang, Pierre Maisonneuve, Ting Jin, Hugo Lavoie, Marc Therrien

Nat Chem Biol· November 2020

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ERK signalling: a master regulator of cell behaviour, life and fate.
Hugo Lavoie, Jessica Gagnon, Marc Therrien

Nat Rev Mol Cell Biol· October 2020

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Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.
Katherine A Rauen, Lisa Schoyer, Lisa Schill, Beth Stronach, John Albeck, Marc Therrien

Am J Med Genet A· December 2018

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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.
Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef, Caroline Baril, Marc Therrien

Nat Commun· October 2018

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MEK drives BRAF activation through allosteric control of KSR proteins.
Hugo Lavoie, Malha Sahmi, Pierre Maisonneuve, Sara A Marullo, Neroshan Thevakumaran, Marc Therrien

Nature· February 2018

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How Genetics Has Helped Piece Together the MAPK Signaling Pathway.
Dariel Ashton-Beaucage, Marc Therrien

Methods Mol Biol· January 2018

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RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.
Ting Jin, Hugo Lavoie, Malha Sahmi, Maud David, Christine Hilt, Marc Therrien

Nat Commun· October 2017

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Validation of sleep-2-Peak: A smartphone application that can detect fatigue-related changes in reaction times during sleep deprivation.
Jean-François Brunet, Dominique Dagenais, Marc Therrien, Daniel Gartenberg, Geneviève Forest

Behav Res Methods· August 2017

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Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.
Peter Kubiniok, Hugo Lavoie, Marc Therrien, Pierre Thibault

Mol Cell Proteomics· April 2017

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Inhibition of RAS function through targeting an allosteric regulatory site.
Russell Spencer-Smith, Akiko Koide, Yong Zhou, Raphael R Eguchi, Fern Sha, Marc Therrien

Nat Chem Biol· January 2017

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Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.
Caroline Baril, Gwenaëlle Gavory, Gawa Bidla, Helene Knævelsrud, Guy Sauvageau, Marc Therrien

Dev Biol· January 2017

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The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.
Dariel Ashton-Beaucage, Caroline Lemieux, Christian M Udell, Malha Sahmi, Samuel Rochette, Marc Therrien

PLoS Biol· August 2016

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Regulation of RAF protein kinases in ERK signalling.
Hugo Lavoie, Marc Therrien

Nat Rev Mol Cell Biol· May 2015

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Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Neroshan Thevakumaran, Hugo Lavoie, David A Critton, Andrew Tebben, Anne Marinier, Marc Therrien

Nat Struct Mol Biol· January 2015

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Dimerization-induced allostery in protein kinase regulation.
Hugo Lavoie, John J Li, Neroshan Thevakumaran, Marc Therrien, Frank Sicheri

Trends Biochem Sci· October 2014

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Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.
Caroline Baril, Martin Lefrançois, Malha Sahmi, Helene Knævelsrud, Marc Therrien

Genetics· August 2014

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