Publications by authors named "Andrew Tebben"

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Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5.
John R D Dawson, Grant M Wadman, Penglie Zhang, Andrew Tebben, Percy H Carter

bioRxiv· February 2024

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BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.
Robert J Cherney, Prakash Anjanappa, Kumaravel Selvakumar, Douglas G Batt, Gregory D Brown, Andrew J Tebben

ACS Med Chem Lett· November 2021

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Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.
Michael G Yang, Zili Xiao, Rulin Zhao, Andrew J Tebben, Bei Wang

ACS Med Chem Lett· June 2021

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An innovative kinome platform to accelerate small-molecule inhibitor discovery and optimization from hits to leads.
Charu Chaudhry, Andrew Tebben, John S Tokarski, Robert Borzilleri, William J Pitts

Drug Discov Today· May 2021

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Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
Hai-Yun Xiao, Ning Li, James J-W Duan, Bin Jiang, Zhonghui Lu, Andrew J Tebben

J Med Chem· December 2020

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Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent.
Upender Velaparthi, Chetan Padmakar Darne, Jayakumar Warrier, Peiying Liu, Hasibur Rahaman, Andrew J Tebben

ACS Med Chem Lett· February 2020

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Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
Scott H Watterson, Qingjie Liu, Myra Beaudoin Bertrand, Douglas G Batt, Ling Li, Andrew J Tebben

J Med Chem· April 2019

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Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.
Michael G Yang, Zili Xiao, Robert J Cherney, Andrew J Tebben, Douglas G Batt

ACS Med Chem Lett· March 2019

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Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor.
Brooke M Katzman, Bryan D Cox, Anthony R Prosser, Ana A Alcaraz, Brigitte Murat, Andrew Tebben

ACS Med Chem Lett· January 2019

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Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents.
Yong Zhang, Yufen Zhao, Andrew J Tebben, Steven Sheriff, Max Ruzanov

ACS Med Chem Lett· November 2018

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Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI).
Lalgudi S Harikrishnan, Jayakumar Warrier, Andrew J Tebben, Gopikishan Tonukunuru, Sudhakara R Madduri

Bioorg Med Chem· March 2018

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Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.
Andrew F Donnell, Yong Zhang, Erik M Stang, Donna D Wei, Andrew J Tebben

Bioorg Med Chem Lett· December 2017

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Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.
Yi Zheng, Ling Qin, Natalia V Ortiz Zacarías, Henk de Vries, Gye Won Han, Andrew Tebben

Nature· December 2016

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Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).
George V De Lucca, Qing Shi, Qingjie Liu, Douglas G Batt, Myra Beaudoin Bertrand, Andrew J Tebben

J Med Chem· September 2016

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Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
John L Gilmore, James E Sheppeck, Scott H Watterson, Lauren Haque, Parag Mukhopadhyay, Andrew J Tebben

J Med Chem· July 2016

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Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity.
Andrew J Tebben, Maxim Ruzanov, Mian Gao, Dianlin Xie, Susan E Kiefer

Acta Crystallogr D Struct Biol· May 2016

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Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.
Audris Huang, Lata Jayaraman, Aberra Fura, Gregory D Vite, George L Trainor, Andrew J Tebben

ACS Med Chem Lett· January 2016

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Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).
Qingjie Liu, Douglas G Batt, Jonathan S Lippy, Neha Surti, Andrew J Tebben

Bioorg Med Chem Lett· October 2015

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Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
Ashvinikumar V Gavai, Claude Quesnelle, Derek Norris, Wen-Ching Han, Patrice Gill, Andrew Tebben

ACS Med Chem Lett· May 2015

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Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.
Percy H Carter, Gregory D Brown, Robert J Cherney, Douglas G Batt, Jing Chen, Andrew J Tebben

ACS Med Chem Lett· April 2015

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Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers.
Michele Modugno, Patrizia Banfi, Fabio Gasparri, Robert Borzilleri, Percy Carter, Andrew Tebben

Exp Cell Res· March 2015

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Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR.
Javed A Khan, Daniel M Camac, Simon Low, Andrew J Tebben, David L Wensel

J Mol Biol· February 2015

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Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Neroshan Thevakumaran, Hugo Lavoie, David A Critton, Andrew Tebben, Anne Marinier

Nat Struct Mol Biol· January 2015

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Macrocycle conformational sampling with MacroModel.
K Shawn Watts, Pranav Dalal, Andrew J Tebben, Daniel L Cheney, John C Shelley

J Chem Inf Model· October 2014

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Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis.
Joseph B Santella, Daniel S Gardner, John V Duncia, Hong Wu, Murali Dhar, Andrew J Tebben

J Med Chem· September 2014

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