Publications by authors named "Marc Whitlow"

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Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.
Imadul Islam, Shendong Yuan, Christopher W West, Marc Adler, Ulrich Bothe, Marc Whitlow

Bioorg Med Chem Lett· November 2018

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ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.
Shinsuke Oshima, Erik E Karrer, Madan M Paidhungat, Margaret Neighbors, Steven J Chapin, Marc Whitlow

Protein Eng Des Sel· May 2016

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Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA).
Christopher W West, Marc Adler, Danny Arnaiz, Deborah Chen, Kieu Chu, Marc Whitlow

Bioorg Med Chem Lett· October 2009

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Potent triazolothione inhibitor of heat-shock protein-90.
Richard I Feldman, Bob Mintzer, Daguang Zhu, James M Wu, Sandra L Biroc, Marc Whitlow

Chem Biol Drug Des· July 2009

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The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex.
Chengliang Wu, Paul Y Kim, Reg Manuel, Marian Seto, Marc Whitlow

J Biol Chem· March 2009

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Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Thomas A Kirkland, Marc Adler, John G Bauman, Ming Chen, Jesper Z Haeggström, Marc Whitlow

Bioorg Med Chem· May 2008

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Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Marc Adler, Brad Buckman, Judi Bryant, Zheng Chang, Kieu Chu, Marc Whitlow

Acta Crystallogr D Biol Crystallogr· February 2008

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.
Imadul Islam, Judi Bryant, Yuo-Ling Chou, Monica J Kochanny, Wheeseong Lee, Marc Whitlow

Bioorg Med Chem Lett· July 2007

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.
Imadul Islam, Greg Brown, Judi Bryant, Paul Hrvatin, Monica J Kochanny, Marc Whitlow

Bioorg Med Chem Lett· July 2007

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Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.
Bin Ye, Damian O Arnaiz, Yuo-Ling Chou, Brian D Griedel, Rushad Karanjawala, Marc Whitlow

J Med Chem· June 2007

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The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase.
Marc Whitlow, Marc Adler, David Davey, Qinglan Huang, Sunil Koovakkat

Bioorg Med Chem Lett· May 2007

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1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
Robert G Wei, Marc Adler, David Davey, Elena Ho, Raju Mohan, Marc Whitlow

Bioorg Med Chem Lett· May 2007

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3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).
Imadul Islam, Judi Bryant, Karen May, Raju Mohan, Shendong Yuan, Marc Whitlow

Bioorg Med Chem Lett· March 2007

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Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Monica J Kochanny, Marc Adler, Janice Ewing, Brian D Griedel, Elena Ho, Marc Whitlow

Bioorg Med Chem· March 2007

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Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
David D Davey, Marc Adler, Damian Arnaiz, Keith Eagen, Shawn Erickson, Marc Whitlow

J Med Chem· March 2007

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Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture.
Jian-Ai Xuan, Doug Schneider, Pam Toy, Rick Lin, Alicia Newton, Marc Whitlow

Cancer Res· April 2006

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The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
Jeffrey T Kohrt, Kevin J Filipski, Wayne L Cody, Cuiman Cai, Danette A Dudley, Marc Whitlow

Bioorg Med Chem Lett· November 2005

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Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase B.
Marc Adler, Judi Bryant, Brad Buckman, Imadul Islam, Brent Larsen, Marc Whitlow

Biochemistry· July 2005

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Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
Richard I Feldman, James M Wu, Mark A Polokoff, Monica J Kochanny, Harald Dinter, Marc Whitlow

J Biol Chem· May 2005

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A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase.
Marian Seto, Marc Whitlow, Margaret A McCarrick, Subha Srinivasan, Ying Zhu

Protein Sci· December 2004

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Crystal structures of two potent nonamidine inhibitors bound to factor Xa.
Marc Adler, Monica J Kochanny, Bin Ye, Galina Rumennik, David R Light, Marc Whitlow

Biochemistry· December 2002

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Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
Gary Phillips, William J Guilford, Brad O Buckman, David D Davey, Keith A Eagen, Marc Whitlow

J Med Chem· June 2002

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Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.
Eric Blasko, Charles B Glaser, James J Devlin, Wei Xia, Richard I Feldman, Marc Whitlow

J Biol Chem· January 2002

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