Publications by authors named "Marcel Ottens"

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Impact of bioreactor process parameters and yeast biomass on Raman spectra.
Maarten Klaverdijk, Mehrab Nemati, Marcel Ottens, Marieke E Klijn

Biotechnol Prog· December 2025

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A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies.
Mariana Carvalho, Ana Cruz, Cees Haringa, Marcel Ottens, Marieke Klijn

Biotechnol Bioeng· December 2025

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Towards Rapid Calibration of Bioprocess Quantification Models Using Single Compound Raman Spectra: A Comparison of Four Approaches.
Maarten Klaverdijk, Lisa A Smulders, Marcel Ottens, Marieke E Klijn

Biotechnol Bioeng· November 2025

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Optimization of multi-column chromatography for capture and polishing at high protein load.
Tiago Castanheira Silva, Madelène Isaksson, Bernt Nilsson, Michel Eppink, Marcel Ottens

Biotechnol Prog· October 2025

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From protein structure to an optimized chromatographic capture step using multiscale modeling.
Daphne Keulen, Tim Neijenhuis, Adamantia Lazopoulou, Roxana Disela, Geoffroy Geldhof, Marcel Ottens

Biotechnol Prog· April 2025

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Comparing in silico flowsheet optimization strategies in biopharmaceutical downstream processes.
Daphne Keulen, Myrto Apostolidi, Geoffroy Geldhof, Olivier Le Bussy, Martin Pabst, Marcel Ottens

Biotechnol Prog· April 2025

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Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models.
Maarten Klaverdijk, Marcel Ottens, Marieke E Klijn

Anal Bioanal Chem· April 2025

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Proteomics-based method to comprehensively model the removal of host cell protein impurities.
Roxana Disela, Daphne Keulen, Eleni Fotou, Tim Neijenhuis, Olivier Le Bussy, Marcel Ottens

Biotechnol Prog· December 2024

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Experimental characterization and prediction of Escherichia coli host cell proteome retention during preparative chromatography.
Roxana Disela, Tim Neijenhuis, Olivier Le Bussy, Geoffroy Geldhof, Marieke Klijn, Marcel Ottens

Biotechnol Bioeng· December 2024

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Application of a fluorescent dye-based microfluidic sensor for real-time detection of mAb aggregates.
Mariana N São Pedro, Michel H M Eppink, Marcel Ottens

Biotechnol Prog· October 2024

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Using artificial neural networks to accelerate flowsheet optimization for downstream process development.
Daphne Keulen, Erik van der Hagen, Geoffroy Geldhof, Olivier Le Bussy, Martin Pabst, Marcel Ottens

Biotechnol Bioeng· August 2024

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Predicting protein retention in ion-exchange chromatography using an open source QSPR workflow.
Tim Neijenhuis, Olivier Le Bussy, Geoffroy Geldhof, Marieke E Klijn, Marcel Ottens

Biotechnol J· March 2024

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Digital twin in high throughput chromatographic process development for monoclonal antibodies.
Tiago Castanheira Silva, Michel Eppink, Marcel Ottens

J Chromatogr A· February 2024

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Real-time detection of mAb aggregates in an integrated downstream process.
Mariana N São Pedro, Madelène Isaksson, Joaquín Gomis-Fons, Michel H M Eppink, Bernt Nilsson, Marcel Ottens

Biotechnol Bioeng· October 2023

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Characterisation of the E. coli HMS174 and BLR host cell proteome to guide purification process development.
Roxana Disela, Olivier Le Bussy, Geoffroy Geldhof, Martin Pabst, Marcel Ottens

Biotechnol J· September 2023

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Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Rita Rosado-Ramos, Gonçalo M Poças, Daniela Marques, Alexandre Foito, David M Sevillano, Marcel Ottens

Nat Commun· April 2023

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Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection.
Mariana N São Pedro, Mafalda S Santos, Michel H M Eppink, Marcel Ottens

Biotechnol J· January 2023

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Small, smaller, smallest: Miniaturization of chromatographic process development.
Tiago Castanheira Silva, Michel Eppink, Marcel Ottens

J Chromatogr A· October 2022

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Recent advances to accelerate purification process development: A review with a focus on vaccines.
Daphne Keulen, Geoffroy Geldhof, Olivier Le Bussy, Martin Pabst, Marcel Ottens

J Chromatogr A· August 2022

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White paper on high-throughput process development for integrated continuous biomanufacturing.
Mariana N São Pedro, Tiago C Silva, Rohan Patil, Marcel Ottens

Biotechnol Bioeng· September 2021

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Anything but Conventional Chromatography Approaches in Bioseparation.
Ana Cecília Afonso Roque, Ana Sofia Pina, Ana Margarida Azevedo, Raquel Aires-Barros, Alois Jungbauer, Marcel Ottens

Biotechnol J· August 2020

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Enzymatic Hydrolysis of Sugarcane Bagasse in Aqueous Two-Phase Systems (ATPS): Exploration and Conceptual Process Design.
Bianca Consorti Bussamra, Paulus Meerman, Vidhvath Viswanathan, Solange I Mussatto, Aline Carvalho da Costa, Marcel Ottens

Front Chem· July 2020

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Systematic Investigation of Insulin Fibrillation on a Chip.
Hoon Suk Rho, Henk-Willem Veltkamp, Alexander Thomas Hanke, Marcel Ottens, Christian Breukers

Molecules· March 2020

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A robotic platform to screen aqueous two-phase systems for overcoming inhibition in enzymatic reactions.
Bianca Consorti Bussamra, Joana Castro Gomes, Sindelia Freitas, Solange I Mussatto, Aline Carvalho da Costa, Marcel Ottens

Bioresour Technol· May 2019

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The Investigation of Protein Diffusion via H-Cell Microfluidics.
Miao Yu, Tiago Castanheira Silva, Andries van Opstal, Stefan Romeijn, Hayley A Every, Marcel Ottens

Biophys J· February 2019

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